PLEKHH2

Description		pleckstrin homology, MyTH4 and FERM domain containing H2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Membrane Nuclear Body Lamellipodium Cortical Actin Cytoskeleton Cell Projection Cell Periphery
	Molecular Function	Actin Binding Protein Binding
	Biological Process	Negative Regulation Of Actin Filament Depolymerization
Pathways
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Coronary artery disease ( 29212778) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Diabetes in response to antihypertensive drug treatment (treatment strategy interaction) ( 27670767) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		2 interacting genes: LPXN PXN
Entrez ID		130271
HPRD ID		15149
Ensembl ID		ENSG00000152527
Uniprot IDs		Q8IVE3
PDB IDs
Enriched GO Terms of Interacting Partners?		Substrate Adhesion-dependent Cell Spreading Endothelial Cell Migration Transforming Growth Factor Beta Receptor Signaling Pathway Cell-substrate Adhesion Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Anchoring Junction Focal Adhesion Signal Complex Assembly Vinculin Binding Enzyme-linked Receptor Protein Signaling Pathway Negative Regulation Of B Cell Receptor Signaling Pathway Neuropilin Binding Cell Adhesion Cell Migration Growth Hormone Receptor Signaling Pathway Regulation Of B Cell Receptor Signaling Pathway Cell Motility Microtubule Associated Complex Podosome Protein-containing Complex Assembly Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of Stress Fiber Assembly Protein-containing Complex Organization Positive Regulation Of Actin Filament Bundle Assembly Stress Fiber Protein Phosphatase Binding Regulation Of Stress Fiber Assembly Beta-catenin Binding Cellular Response To Reactive Oxygen Species Cell Surface Receptor Signaling Pathway Transcription Coregulator Activity
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