COL11A1 and ITGAV

Number of citations of the paper that reports this interaction (PubMedID 19542224)
57

Data Source:
BioGRID (pull down)

		COL11A1	ITGAV
Description		collagen type XI alpha 1 chain	integrin subunit alpha V
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Fibrillar Collagen Trimer Collagen Type II Trimer Collagen Type XI Trimer Endoplasmic Reticulum Lumen Extracellular Matrix	Cytosol Plasma Membrane Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Membrane Lamellipodium Membrane Filopodium Membrane Microvillus Membrane Ruffle Membrane Integrin Alphav-beta1 Complex Integrin Alphav-beta3 Complex Integrin Alphav-beta5 Complex Integrin Alphav-beta6 Complex Integrin Alphav-beta8 Complex Specific Granule Membrane Alphav-beta3 Integrin-PKCalpha Complex Alphav-beta3 Integrin-IGF-1-IGF1R Complex Alphav-beta3 Integrin-HMGB1 Complex Phagocytic Vesicle Extracellular Exosome Anchoring Junction
	Molecular Function	Extracellular Matrix Structural Constituent Extracellular Matrix Structural Constituent Conferring Tensile Strength Protein-macromolecule Adaptor Activity Metal Ion Binding Extracellular Matrix Binding	Virus Receptor Activity Opsonin Binding Fibronectin Binding Protease Binding Protein Kinase C Binding Signaling Receptor Binding Integrin Binding Protein Binding Coreceptor Activity Fibroblast Growth Factor Binding C-X3-C Chemokine Binding Insulin-like Growth Factor I Binding Signaling Receptor Activity Neuregulin Binding Metal Ion Binding Transforming Growth Factor Beta Binding Extracellular Matrix Binding Extracellular Matrix Protein Binding
	Biological Process	Cartilage Condensation Chondrocyte Development Heart Morphogenesis Proteoglycan Metabolic Process Visual Perception Sensory Perception Of Sound Collagen Fibril Organization Endodermal Cell Differentiation Tendon Development Inner Ear Morphogenesis Embryonic Skeletal System Morphogenesis Skeletal System Morphogenesis Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Cartilage Development Ventricular Cardiac Muscle Tissue Morphogenesis	Angiogenesis Blood Vessel Development Vasculogenesis Formation Of Primary Germ Layer Cell Adhesion Cell-matrix Adhesion Positive Regulation Of Cytosolic Calcium Ion Concentration Integrin-mediated Signaling Pathway Positive Regulation Of Cell Population Proliferation Tissue Development Negative Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Lipid Storage Negative Regulation Of Low-density Lipoprotein Particle Clearance Cell Migration Positive Regulation Of Cell Migration Cell-substrate Adhesion Negative Regulation Of Lipid Transport Cell Adhesion Mediated By Integrin Positive Regulation Of Osteoblast Proliferation Heterotypic Cell-cell Adhesion Substrate Adhesion-dependent Cell Spreading Wound Healing, Spreading Of Epidermal Cells Endodermal Cell Differentiation Apolipoprotein A-I-mediated Signaling Pathway Apoptotic Cell Clearance Positive Regulation Of Cell Adhesion Symbiont Entry Into Host Cell Negative Regulation Of Lipoprotein Metabolic Process Regulation Of Phagocytosis Negative Chemotaxis Positive Regulation Of Small GTPase Mediated Signal Transduction ERK1 And ERK2 Cascade Calcium Ion Transmembrane Transport Transforming Growth Factor Beta Production Entry Into Host Cell By A Symbiont-containing Vacuole Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Cell-cell Adhesion Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Entry Of Bacterium Into Host Cell Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Collagen degradation Collagen degradation Collagen biosynthesis and modifying enzymes Assembly of collagen fibrils and other multimeric structures Non-integrin membrane-ECM interactions MET activates PTK2 signaling Collagen chain trimerization Developmental Lineage of Pancreatic Ductal Cells	Cross-presentation of particulate exogenous antigens (phagosomes) Elastic fibre formation PECAM1 interactions Molecules associated with elastic fibres Integrin cell surface interactions Integrin cell surface interactions TGF-beta receptor signaling activates SMADs Laminin interactions Syndecan interactions Syndecan interactions ECM proteoglycans VEGFA-VEGFR2 Pathway Signal transduction by L1 Neutrophil degranulation Mechanical load activates signaling by PIEZO1 and integrins in osteocytes Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Drugs			Antithymocyte immunoglobulin (rabbit) Levothyroxine PLN-74809
Diseases		Type XI collagenopathies, including: Stickler syndrome type 2; Stickler syndrome type 3; Otospondylomegaepiphyseal dysplasia (OSMED); Marshall syndrome; Weissenbacher-Zweymuller syndrome Vitreoretinal degeneration, including: Stickler syndrome type I (STL1); Stickler syndrome type II (STL2); Snowflake vitreoretinal degeneration (SVD); Wagner syndrome 1 (WGN1); Knobloch syndrome (KNO); Enhanced S-cone syndrome (ESCS); Autosomal dominant vitreoretinochoroidopathy (ADVIRC)
GWAS		Bone mineral density change response to combined chemotherapy in acute lymphoblastic leukemia ( 29266176) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Carpal tunnel syndrome ( 30833571) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Extremely high intelligence ( 29520040) Femoral neck bone mineral density ( 22504420) Glaucoma (primary angle closure) ( 27064256 22922875) Glaucoma (primary open-angle) ( 29891935) Heel bone mineral density ( 30598549) Height ( 28552196) Hip bone size ( 31053729) Hip circumference adjusted for BMI ( 34021172) Intelligence (MTAG) ( 29326435) Intertrochanteric region size ( 31053729) Lateral ventricle temporal horn volume ( 31530798) Open-angle glaucoma and optic cup area ( 29449654) Osteoarthritis (hip) ( 30374069) Protein quantitative trait loci ( 18464913) Spine bone size ( 31053729) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Systemic juvenile idiopathic arthritis ( 27927641) Tinnitus ( 32970095) Triglyceride levels x loop diuretics use interaction ( 31806883) Trochanter size ( 31053729) Urate levels (BMI interaction) ( 25811787) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Asthma ( 32296059) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Left-handedness ( 32989287) Lung function (FEV1/FVC) ( 30804560) Microalbuminuria ( 26631737) Urinary albumin-to-creatinine ratio ( 26631737) Urinary albumin-to-creatinine ratio in non-diabetics ( 26631737)
Interacting Genes		6 interacting genes: APP DDR1 ITGAV SPARC TGM2 THBS1	38 interacting genes: ADAM9 ANGPTL3 AUP1 AZGP1 CALR CCN1 CCN3 CD47 COL11A1 COL18A1 COL6A1 EDIL3 F2R ICAM4 ITGB1 ITGB3 ITGB5 ITGB6 ITGB8 L1CAM LGALS3BP MAPK3 MMP14 MMP2 NID1 P2RY2 PAK4 PDGFRA PLA2G2A PLP1 PTK2 PXN SPP1 TGFB1 TGM2 THY1 UBC VTN
Entrez ID		1301	3685
HPRD ID		00375	01903
Ensembl ID		ENSG00000060718	ENSG00000138448
Uniprot IDs		P12107 Q59HB5	L7RXH0 P06756
PDB IDs			1JV2 1L5G 1M1X 1U8C 3IJE 4G1E 4G1M 4MMX 4MMY 4MMZ 4O02 4UM8 4UM9 5FFG 5FFO 5NEM 5NER 5NET 5NEU 6AVQ 6AVR 6AVU 6DJP 6MK0 6MSL 6MSU 6NAJ 6OM1 6OM2 6UJA 6UJB 6UJC 7Y1T 8IJ5 8TCF 8TCG 8VS6 8VSD 8W30 8XEI 8XEK 8XEL 8XEN 8XER 8XEZ 8XF6 8XFG 8XFO 9CZ7 9CZA 9CZD 9CZF 9IND
Enriched GO Terms of Interacting Partners?		Platelet Alpha Granule Extracellular Matrix Binding Platelet Alpha Granule Lumen Regulation Of Cellular Component Organization Regulation Of Extrinsic Apoptotic Signaling Pathway Integrin Binding Anatomical Structure Morphogenesis Positive Regulation Of Cell Migration Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Motility Cellular Response To Catecholamine Stimulus Positive Regulation Of Locomotion Response To Catecholamine Transforming Growth Factor Beta Binding Fibroblast Growth Factor Binding Cell Surface Apoptotic Cell Clearance Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Cell Population Proliferation Regulation Of Cell Population Proliferation Positive Regulation Of Signal Transduction Wound Healing, Spreading Of Cells Fibronectin Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cell Adhesion Negative Regulation Of Lipid Transport Cell Adhesion Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Tube Morphogenesis Regulation Of Intracellular Signal Transduction Regulation Of Endocytosis Regulation Of Angiogenesis Extracellular Exosome Regulation Of Cell Migration Extracellular Region Regulation Of Vasculature Development Negative Regulation Of Endothelial Cell Proliferation External Side Of Plasma Membrane Regulation Of Sprouting Angiogenesis Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cell Motility Regulation Of Locomotion Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Apoptotic Signaling Pathway Collagen Binding Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Developmental Process Regulation Of Response To Calcium Ion	Integrin Binding Cell Adhesion Integrin-mediated Signaling Pathway Cell Adhesion Mediated By Integrin Focal Adhesion Extracellular Matrix Positive Regulation Of Cell Migration Cell-matrix Adhesion Positive Regulation Of Cell Motility Cell-substrate Adhesion Positive Regulation Of Locomotion Angiogenesis Cell-cell Adhesion Cell Migration Regulation Of Cell Adhesion Anatomical Structure Formation Involved In Morphogenesis Regulation Of Cell Migration Regulation Of Cell Motility Cell Motility Regulation Of Locomotion Cell Surface Enzyme-linked Receptor Protein Signaling Pathway Extracellular Matrix Binding Transforming Growth Factor Beta Receptor Signaling Pathway Extracellular Matrix Organization Extracellular Structure Organization Endodermal Cell Differentiation Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Extracellular Region Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Multicellular Organismal Process Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Mononuclear Cell Migration Regulation Of Cell-substrate Adhesion Positive Regulation Of Leukocyte Migration Regulation Of Leukocyte Migration Extracellular Exosome Positive Regulation Of Mononuclear Cell Migration Positive Regulation Of Multicellular Organismal Process Integrin Complex Developmental Process Regulation Of Cellular Component Organization Positive Regulation Of Cell Adhesion Response To Mechanical Stimulus Positive Regulation Of Cell-substrate Adhesion Cellular Developmental Process Cell Differentiation Extracellular Space Positive Regulation Of Fibroblast Migration
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