FAM168B and CAMK2A

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FAM168B	CAMK2A
Description		family with sequence similarity 168 member B	calcium/calmodulin dependent protein kinase II alpha
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane Axon Cell Projection Perinuclear Region Of Cytoplasm Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Calcium- And Calmodulin-dependent Protein Kinase Complex Postsynaptic Density Dendrite Endocytic Vesicle Membrane Cell Projection Neuron Projection Dendritic Spine Synapse
	Molecular Function	Protein Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium/calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding Kinase Activity Transferase Activity Glutamate Receptor Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process		G1/S Transition Of Mitotic Cell Cycle Response To Ischemia Protein Phosphorylation Calcium Ion Transport Cell Surface Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Cellular Response To Interferon-beta Angiotensin-activated Signaling Pathway Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Regulation Of Neurotransmitter Secretion Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Hydrolase Activity Positive Regulation Of Calcium Ion Transport Long-term Synaptic Potentiation Dendritic Spine Development Cellular Response To Type II Interferon Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Regulation Of Protein Localization To Plasma Membrane Peptidyl-threonine Autophosphorylation Regulation Of Endocannabinoid Signaling Pathway Regulation Of Neuron Migration
Pathways			CaMK IV-mediated phosphorylation of CREB HSF1-dependent transactivation Trafficking of AMPA receptors Ca2+ pathway Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor Phase 0 - rapid depolarisation Ion homeostasis RAF activation RAF/MAP kinase cascade Signaling by moderate kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Interferon gamma signaling Regulation of MECP2 expression and activity Ion transport by P-type ATPases Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation Signaling downstream of RAS mutants Signaling by RAF1 mutants
Drugs			Hexatantalum Dodecabromide 1,4-Dithiothreitol (2Z,3E)-2,3'-biindole-2',3(1H,1'H)-dione 3-{O-[(3R)-3,4-dihydroxybutyl]oxime} Fostamatinib
Diseases
GWAS			Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Inflammatory bowel disease ( 28067908) Obesity-related traits ( 23251661) Retinitis pigmentosa ( 33514863) Ulcerative colitis ( 28067908)
Interacting Genes		51 interacting genes: AGXT ARID5A BAG3 CAMK2A CCNK CSTF2 CSTF2T EGLN3 FAM168A FAM222B FOXH1 FOXI1 GLIS2 GPS2 HOXB9 HSF4 KRTAP26-1 LASP1 MED25 MSRB3 MYOZ3 NEDD9 OTX1 PATZ1 PITX1 POGZ POM121 PRR35 RAMAC RBFOX2 RHOXF2 ROR2 SAMD7 SAXO4 SNRPB SNRPC SPAG8 TCF7L2 TENT5B TIAL1 TLE5 TLX3 UBAP2 VENTX VEZF1 VGLL3 VPS37C WDR25 YPEL3 ZC3H10 ZIC1	89 interacting genes: ACTN1 ACTN2 ACTN4 ARID5A ATF1 ATP2A2 C1orf94 CACNA1B CAMK2N2 CDC37 CDK5R1 CDK5R2 CEBPB CHAT CREB1 DAPK2 DAZAP2 DLG1 DSCAM EGFR ETS1 FAM168A FAM168B FXR1 GFAP GLB1L2 GRIA1 GRIN1 GRIN2A GRIN2B GRM5 HSF1 HYAL3 ITGA2B ITGB1BP1 ITPKA KRT18 KRT75 KRT76 KRTAP15-1 KRTAP19-3 KRTAP19-5 KRTAP19-7 KRTAP22-1 KRTAP23-1 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP8-1 LASP1 LENG8 LRRC7 MAPT MPDZ MRPL11 NOS1 NTAQ1 PDC PPM1F PSMC5 PTTG1 RALYL RBFOX2 RBM47 RBPMS RBPMS2 RCHY1 RHOXF2 RIMS1 SMAD2 SOX5 SPMIP9 SQSTM1 SRF STAT1 SUOX SYNGAP1 TAB2 TANC1 TCAF1 TFAP2D TIAL1 TRIM55 TRIM63 TSR2 TTC5 VARS1 YWHAB ZBTB32
Entrez ID		130074	815
HPRD ID		17295	06532
Ensembl ID		ENSG00000152102	ENSG00000070808
Uniprot IDs		A1KXE4	A0A5F9ZH21 A8K161 Q7LDD5 Q8IWE0 Q9UQM7
PDB IDs			2VZ6 3SOA 5IG3 6OF8 6VZK 6W4O 6W4P 6X5G 6X5Q 7KL0 7KL1 7KL2 7REC 7UIQ 7UIR 7UIS 7UJP 7UJQ 7UJR 7UJS 7UJT 9EOY
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription By RNA Polymerase II Nucleus Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Nucleoplasm Sequence-specific Double-stranded DNA Binding Regulation Of Primary Metabolic Process Regulation Of Gene Expression Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Myoblast Fate Commitment Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Metabolic Process DNA Binding DNA-binding Transcription Factor Activity Negative Regulation Of RNA Metabolic Process Positive Regulation Of Protein Localization To Nucleus Chromatin Transcription Corepressor Activity Protein Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Inner Ear Morphogenesis Transcription Regulator Complex MRNA Cleavage And Polyadenylation Specificity Factor Complex Transcription Cis-regulatory Region Binding U2-type Prespliceosome Negative Regulation Of Androgen Receptor Signaling Pathway Nuclear Retinoid X Receptor Binding Regulation Of Protein Localization To Nucleus U1 SnRNP Embryonic Morphogenesis	Intermediate Filament Regulation Of Synaptic Plasticity Dendritic Spine Modulation Of Chemical Synaptic Transmission Learning Or Memory Cognition Postsynaptic Density Glutamate-gated Calcium Ion Channel Activity Identical Protein Binding Neuron Projection Glutamate Receptor Signaling Pathway Ionotropic Glutamate Receptor Signaling Pathway Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Excitatory Postsynaptic Potential Associative Learning Positive Regulation Of Synaptic Transmission Synapse Postsynaptic Density Membrane Intracellular Signaling Cassette Learning Ligand-gated Ion Channel Signaling Pathway Regulation Of Membrane Potential Cytosol NMDA Glutamate Receptor Activity Cell Junction Organization Modulation Of Excitatory Postsynaptic Potential Transmembrane Transporter Binding Positive Regulation Of Macromolecule Biosynthetic Process Visual Learning Positive Regulation Of Metabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling NMDA Selective Glutamate Receptor Complex Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Synaptic Signaling Regulation Of Postsynaptic Membrane Potential Postsynaptic Actin Cytoskeleton Excitatory Chemical Synaptic Transmission Kinase Binding Visual Behavior Positive Regulation Of Biosynthetic Process Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Nucleobase-containing Compound Metabolic Process Synaptic Membrane Ligand-gated Monoatomic Ion Channel Activity Protein Kinase Binding Regulation Of Nucleobase-containing Compound Metabolic Process Superior Olivary Nucleus Maturation
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