COL8A1 and ITGA2

Number of citations of the paper that reports this interaction (PubMedID 10666376)
48

Data Source:
HPRD (in vitro)

		COL8A1	ITGA2
Description		collagen type VIII alpha 1 chain	integrin subunit alpha 2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Collagen Type VIII Trimer Basement Membrane Endoplasmic Reticulum Lumen Extracellular Matrix	Plasma Membrane Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Membrane Axon Integrin Alpha2-beta1 Complex Cell Projection Axon Terminus Basal Part Of Cell Perinuclear Region Of Cytoplasm Presynapse
	Molecular Function	Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength	Amyloid-beta Binding Virus Receptor Activity Integrin Binding Protein Binding Collagen Binding Signaling Receptor Activity Collagen Receptor Activity Laminin Binding Heparan Sulfate Proteoglycan Binding Protein-containing Complex Binding Metal Ion Binding Collagen Binding Involved In Cell-matrix Adhesion
	Biological Process	Angiogenesis Endothelial Cell Proliferation Cell Adhesion Positive Regulation Of Cell-substrate Adhesion Endodermal Cell Differentiation Camera-type Eye Morphogenesis	Response To Hypoxia Positive Regulation Of Leukocyte Migration Substrate-dependent Cell Migration Hypotonic Response Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Female Pregnancy Blood Coagulation Response To Xenobiotic Stimulus Animal Organ Morphogenesis Positive Regulation Of Epithelial Cell Migration Response To Amine Response To Muscle Activity Positive Regulation Of Smooth Muscle Cell Migration Extracellular Matrix Organization Mammary Gland Development Positive Regulation Of Cell Projection Organization Cell-substrate Adhesion Positive Regulation Of Collagen Biosynthetic Process Response To L-ascorbic Acid Cell Adhesion Mediated By Integrin Collagen-activated Signaling Pathway Skin Morphogenesis Positive Regulation Of Translation Positive Regulation Of Cell Adhesion Positive Regulation Of Smooth Muscle Contraction Symbiont Entry Into Host Cell Focal Adhesion Assembly Mesodermal Cell Differentiation Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Positive Chemotaxis Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Positive Regulation Of Transmission Of Nerve Impulse Positive Regulation Of Phagocytosis, Engulfment Hepatocyte Differentiation Response To Parathyroid Hormone Cellular Response To Mechanical Stimulus Cellular Response To Estradiol Stimulus Cell-cell Adhesion
Pathways		Collagen degradation Collagen degradation Collagen biosynthesis and modifying enzymes Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Collagen chain trimerization	Integrin cell surface interactions Integrin cell surface interactions Laminin interactions Laminin interactions Syndecan interactions ECM proteoglycans CHL1 interactions Platelet Adhesion to exposed collagen MET activates PTK2 signaling Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition
Drugs
Diseases
GWAS		A body shape index ( 34021172) Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration ( 23455636 20385826) Axial length ( 24144296) Childhood ear infection ( 27182965) Hip index ( 34021172) Nonsyndromic cleft lip with cleft palate ( 28232668) Optic cup area ( 28073927 31798171 25631615) Optic disc area ( 28073927 31798171) Refractive error ( 32231278) Serum alkaline phosphatase levels ( 33547301) Superior frontal gyrus grey matter volume ( 25335168) Vertical cup-disc ratio ( 28073927 31798171 25241763) Waist circumference adjusted for body mass index ( 34021172)	Acne (severe) ( 24927181) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Keratoconus ( 33649486) Mean platelet volume ( 32888494) Platelet distribution width ( 32888494) Type 2 diabetes ( 30130595)
Interacting Genes		78 interacting genes: ACTMAP ADAMTSL4 ARMC5 BPIFA1 C22orf39 CCN3 CEP55 CFAP68 CIDEB COL8A2 CREB5 CYSRT1 DPEP2NB EFEMP2 FAM86C1P FBLN2 FBXO34 FRS3 GLRX3 GSC2 HOXA1 INCA1 ITGA1 ITGA2 KLHL12 KLHL20 KPRP KRT37 KRT40 KRT82 KRTAP1-3 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP12-3 KRTAP13-1 KRTAP13-3 KRTAP19-2 KRTAP19-5 KRTAP19-7 KRTAP26-1 KRTAP3-2 KRTAP4-12 KRTAP5-6 KRTAP5-7 KRTAP5-9 KRTAP6-2 KRTAP6-3 KRTAP9-2 KRTAP9-3 LIMS1 MAJIN NADSYN1 NBPF19 NOTCH2NLA OTX1 PLSCR3 POF1B POU4F2 PPARA RBPMS REL RGS20 RHBDD2 SLC35A2 SP4 SPATA8 SPMIP6 SPRY4 SSC4D TRIM35 UBQLN2 UBQLN4 VAC14 WFDC5 YPEL3 ZNF774 ZNHIT1	13 interacting genes: ACTA1 APP AUP1 CD9 COL1A1 COL1A2 COL8A1 HSPG2 ITGB1 LAMA1 MMP1 RABIF TSC22D2
Entrez ID		1295	3673
HPRD ID		00372	01893
Ensembl ID		ENSG00000144810	ENSG00000164171
Uniprot IDs		P27658	P17301
PDB IDs			1AOX 1DZI 1V7P 4BJ3 5HJ2 5THP 6ND8 6ND9 6NDA 6NDB 6NDC 6NDD 6NDE 6NDF 6NDG 6NDH
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Identical Protein Binding Collagen Binding Involved In Cell-matrix Adhesion Cytosol Structural Constituent Of Skin Epidermis	Extracellular Matrix Extracellular Matrix Organization Extracellular Structure Organization Collagen Type I Trimer Extracellular Matrix Structural Constituent Extracellular Matrix Structural Constituent Conferring Tensile Strength Extracellular Space Integrin Binding Extracellular Region Regulation Of Spontaneous Synaptic Transmission Bone Trabecula Formation Collagen Metabolic Process Fibrillar Collagen Trimer Anatomical Structure Formation Involved In Morphogenesis Collagen Trimer Platelet-derived Growth Factor Binding Skin Morphogenesis Basement Membrane Anatomical Structure Morphogenesis Regulation Of Cell Migration Endoplasmic Reticulum Lumen Protein Trimerization Regulation Of Cell Motility Protease Binding Regulation Of Amyloid Fibril Formation Regulation Of Locomotion Regulation Of Neurotransmitter Uptake Low-density Lipoprotein Particle Receptor Binding Myoblast Fusion Cellular Response To Low-density Lipoprotein Particle Stimulus Regulation Of Cell Adhesion Receptor-mediated Endocytosis Endocytosis Cell-cell Fusion Syncytium Formation By Plasma Membrane Fusion Cell Adhesion Cellular Response To Lipoprotein Particle Stimulus Syncytium Formation Positive Regulation Of Cell Differentiation Extracellular Exosome Cellular Developmental Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Cellular Response To Vitamin E Animal Organ Morphogenesis Protein Heterotrimerization Myoblast Fate Specification
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?