COL8A1 and CFAP68

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		COL8A1	CFAP68
Description		collagen type VIII alpha 1 chain	cilia and flagella associated protein 68
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Collagen Type VIII Trimer Basement Membrane Endoplasmic Reticulum Lumen Extracellular Matrix	Nucleus Nucleoplasm Cytoplasm Cytoskeleton Cilium Axoneme Motile Cilium Sperm Flagellum Cell Projection Axonemal A Tubule Inner Sheath
	Molecular Function	Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength	Protein Binding
	Biological Process	Angiogenesis Endothelial Cell Proliferation Cell Adhesion Positive Regulation Of Cell-substrate Adhesion Endodermal Cell Differentiation Camera-type Eye Morphogenesis	Flagellated Sperm Motility
Pathways		Collagen degradation Collagen degradation Collagen biosynthesis and modifying enzymes Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Collagen chain trimerization
Drugs
Diseases
GWAS		A body shape index ( 34021172) Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration ( 23455636 20385826) Axial length ( 24144296) Childhood ear infection ( 27182965) Hip index ( 34021172) Nonsyndromic cleft lip with cleft palate ( 28232668) Optic cup area ( 28073927 31798171 25631615) Optic disc area ( 28073927 31798171) Refractive error ( 32231278) Serum alkaline phosphatase levels ( 33547301) Superior frontal gyrus grey matter volume ( 25335168) Vertical cup-disc ratio ( 28073927 31798171 25241763) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		78 interacting genes: ACTMAP ADAMTSL4 ARMC5 BPIFA1 C22orf39 CCN3 CEP55 CFAP68 CIDEB COL8A2 CREB5 CYSRT1 DPEP2NB EFEMP2 FAM86C1P FBLN2 FBXO34 FRS3 GLRX3 GSC2 HOXA1 INCA1 ITGA1 ITGA2 KLHL12 KLHL20 KPRP KRT37 KRT40 KRT82 KRTAP1-3 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP12-3 KRTAP13-1 KRTAP13-3 KRTAP19-2 KRTAP19-5 KRTAP19-7 KRTAP26-1 KRTAP3-2 KRTAP4-12 KRTAP5-6 KRTAP5-7 KRTAP5-9 KRTAP6-2 KRTAP6-3 KRTAP9-2 KRTAP9-3 LIMS1 MAJIN NADSYN1 NBPF19 NOTCH2NLA OTX1 PLSCR3 POF1B POU4F2 PPARA RBPMS REL RGS20 RHBDD2 SLC35A2 SP4 SPATA8 SPMIP6 SPRY4 SSC4D TRIM35 UBQLN2 UBQLN4 VAC14 WFDC5 YPEL3 ZNF774 ZNHIT1	35 interacting genes: AGXT ANKRD11 ARMC7 ATG9A ATPAF2 CATSPER1 CNOT2 COL8A1 DMRT3 DTX2 FOXH1 FRS3 HGS HOXA1 HOXC8 HR KANK2 KLHL38 KRTAP13-2 MGAT5B MYO15B OTX1 PATZ1 PEF1 PITX1 PLSCR4 PRKAB2 PROP1 PRR35 SETDB1 SMYD1 TEKT4 TLE5 TLX3 ZIC1
Entrez ID		1295	64776
HPRD ID		00372	12601
Ensembl ID		ENSG00000144810	ENSG00000137720
Uniprot IDs		P27658	E9PS93 Q9H5F2
PDB IDs			7UNG 8J07
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Identical Protein Binding Collagen Binding Involved In Cell-matrix Adhesion Cytosol Structural Constituent Of Skin Epidermis	Sequence-specific Double-stranded DNA Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Chromatin Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Anatomical Structure Morphogenesis Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Phospholipid Scramblase Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Corepressor Activity Plasma Membrane Phospholipid Scrambling Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Pattern Specification Process
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