PUSL1 and PLEKHN1

		PUSL1	PLEKHN1
Description		pseudouridine synthase like 1	pleckstrin homology domain containing N1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Mitochondrion	Mitochondrion Cytosol Cytoskeleton Plasma Membrane Membrane Mitochondrial Membrane
	Molecular Function	RNA Binding Pseudouridine Synthase Activity Isomerase Activity TRNA Pseudouridine Synthase Activity	Phosphatidylserine Binding Protein Binding Phosphatidic Acid Binding Cardiolipin Binding Phosphatidylinositol Phosphate Binding
	Biological Process	Pseudouridine Synthesis TRNA Processing RNA Modification TRNA Pseudouridine Synthesis	Response To Hypoxia Positive Regulation Of Apoptotic Process 3'-UTR-mediated MRNA Destabilization
Pathways
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 28067908) Ulcerative colitis ( 28067908)	Height ( 31562340) Parkinson's disease ( 26227905)
Interacting Genes		2 interacting genes: APP FBXO7	42 interacting genes: ABI2 AKAP8L ARID5A ATXN1 CBY2 CYSRT1 FHL5 HOXA1 KRT31 KRT36 KRT83 KRTAP1-3 KRTAP19-6 KRTAP6-2 LPXN LZTS2 MTUS2 NBPF19 NFKBID NOTCH2NLA PDLIM7 PIH1D1 PPM1J PPP1R16B PRICKLE4 PRKAA2 REL RFX6 SAXO4 SORBS3 SSC4D TAX1BP1 TCF4 TP53BP2 TRAF1 TRIM27 TRIP6 USP54 WWOX ZC4H2 ZNF438 ZRANB1
Entrez ID		126789	84069
HPRD ID		08301	13190
Ensembl ID		ENSG00000169972	ENSG00000187583
Uniprot IDs		Q8N0Z8	Q494U1
PDB IDs
Enriched GO Terms of Interacting Partners?		Ubiquitin Ligase Complex Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Positive Regulation Of Catabolic Process Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Notch Signaling Pathway Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Lewy Body Core Protein Ubiquitination Protein Modification By Small Protein Conjugation Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Post-translational Protein Modification Axon Choice Point Recognition Heparan Sulfate Binding Signaling Receptor Activator Activity Peptidase Activator Activity Regulation Of Neuron Apoptotic Process Cellular Response To Manganese Ion Ubiquitin-protein Transferase Activity	Intermediate Filament Structural Constituent Of Skin Epidermis Keratin Filament
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