KRABD2 and HDAC7

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		KRABD2	HDAC7
Name		KRAB domain containing 2	histone deacetylase 7
Structure		No pdb structure
GO Annotations	Cellular Component	None	Histone Deacetylase Complex Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Nucleic Acid Binding Protein Binding	Chromatin Binding Transcription Corepressor Activity Histone Deacetylase Activity Protein Kinase C Binding Protein Binding Hydrolase Activity SUMO Transferase Activity Protein Kinase Binding Protein Lysine Deacetylase Activity Metal Ion Binding 14-3-3 Protein Binding DNA-binding Transcription Factor Binding Histone Deacetylase Activity, Hydrolytic Mechanism
	Biological Process	Regulation Of DNA-templated Transcription DNA Integration	Negative Regulation Of Transcription By RNA Polymerase II Vasculogenesis Chromatin Organization Protein Deacetylation Cell-cell Junction Assembly Negative Regulation Of Macromolecule Biosynthetic Process Protein Sumoylation Negative Regulation Of Interleukin-2 Production Epigenetic Regulation Of Gene Expression Negative Regulation Of Osteoblast Differentiation Negative Regulation Of DNA-templated Transcription Regulation Of MRNA Processing Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Membraneless Organelle Assembly Negative Regulation Of Non-canonical NF-kappaB Signal Transduction
Pathways		None	NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants SUMOylation of DNA damage response and repair proteins Notch-HLH transcription pathway Regulation of PTEN gene transcription
Drugs		None	Valproic acid Decitabine Vorinostat Trichostatin A Belinostat Romidepsin Panobinostat Phenylbutyric acid Entinostat Abexinostat Givinostat Pyroxamide
GWAS		No GWAS studies recorded	A body shape index ( 34021172 ) Allergic disease (asthma, hay fever or eczema) ( 29083406 ) Asthma ( 32296059 31361310 30929738 ) Asthma (adult onset) ( 31036433 30929738 ) Bipolar disorder ( 31043756 ) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007 ) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143 ) Conjunctival UV autofluorescence (CUVAF) ( 25590795 ) Diastolic blood pressure ( 27841878 ) Fasting insulin ( 34059833 ) Haemorrhoidal disease ( 33888516 ) Inflammatory bowel disease ( 28067908 ) Lymphocyte count ( 27863252 32888494 ) Lymphocyte percentage of white cells ( 32888494 ) Mean corpuscular hemoglobin ( 32888494 ) Mean corpuscular volume ( 32888494 ) Mean platelet volume ( 32888494 ) Mean reticulocyte volume ( 32888494 ) Medication use (agents acting on the renin-angiotensin system) ( 31015401 ) Neutrophil percentage of white cells ( 32888494 ) Obesity-related traits ( 23251661 ) Platelet count ( 27863252 32888494 ) Platelet distribution width ( 32888494 ) Plateletcrit ( 32888494 27863252 ) Primary sclerosing cholangitis ( 23603763 ) Systolic blood pressure ( 27841878 ) Ulcerative colitis ( 28067908 ) Urate levels ( 23263486 ) Waist circumference adjusted for body mass index ( 34021172 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 ) White blood cell count ( 32888494 )
Novel Interactors		2 novel interactors: CNTROB DNAH2	None recorded
Interacting Genes		1 interacting genes: HDAC7	59 interacting genes: ACOT11 ACTN4 ANTKMT ARID5A BCL6 BRWD1 C3orf36 CALCOCO2 CASP8 CDC42 CENPQ DDIT4L EDNRA EGFR ESM1 GNG12 GNMT GOLGA6L9 HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 KAT5 KLF16 KRABD2 LDB2 MARK2 MARK3 MEF2A MEF2C MEOX2 MIEN1 MTCL2 NCOR2 NME4 NRIP2 PATJ PHC2 PPARD PPP1R16A PRKD1 PRKD2 RAC1 RAC2 RAC3 REL RIPPLY1 RRAS2 RUNX2 SIN3A SLC16A3 UBC UBE2I UBL3 YPEL3 YWHAG YWHAQ ZBTB16
Entrez ID		124751	51564
HPRD ID		14028	09133
Ensembl ID		ENSG00000184619	ENSG00000061273
Uniprot IDs		A8MX02 Q6ZNG9	Q8WUI4
PDB IDs		Not available	3C0Y 3C0Z 3C10 3ZNR 3ZNS 8Q9Q
GO Terms Enriched among Interactors		Histone Deacetylase Activity Macromolecule Deacylation Negative Regulation Of Non-canonical NF-kappaB Signal Transduction 14-3-3 Protein Binding Protein Deacetylation SUMO Transferase Activity Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Protein Lysine Deacetylase Activity Membraneless Organelle Assembly Negative Regulation Of Interleukin-2 Production Histone Deacetylase Activity, Hydrolytic Mechanism Cellular Component Assembly Organelle Assembly Mitotic Cytokinetic Process Centriole Assembly Centriole Replication Microtubule-based Process Centrosome Separation Inner Dynein Arm 9+2 Motile Cilium Dynein Intermediate Chain Binding Axonemal Dynein Complex Assembly Minus-end-directed Microtubule Motor Activity Inner Dynein Arm Assembly Dynein Light Intermediate Chain Binding Axonemal Dynein Complex Dynein Complex Cytokinetic Process Histone Deacetylase Complex Protein Kinase C Binding Protein Sumoylation Regulation Of Cell Migration Involved In Sprouting Angiogenesis	Regulation Of Cell Motility Regulation Of Locomotion Regulation Of Cell Migration Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Histone Deacetylase Activity, Hydrolytic Mechanism Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Binding Protein Lysine Deacetylase Activity Intracellular Signal Transduction Negative Regulation Of Nucleobase-containing Compound Metabolic Process Histone Deacetylase Activity Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Biosynthetic Process Chromatin Binding Histone Deacetylase Complex Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Histone Deacetylase Binding Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Protein Lysine Delactylase Activity Negative Regulation Of Macromolecule Metabolic Process Transcription Repressor Complex Regulation Of RNA Metabolic Process Intracellular Signaling Cassette Protein Decrotonylase Activity Histone Decrotonylase Activity Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Myotube Differentiation Positive Regulation Of Cell Motility Regulation Of Striated Muscle Cell Differentiation Transcription Corepressor Binding Positive Regulation Of Locomotion Positive Regulation Of Intracellular Signal Transduction Regulation Of Metabolic Process G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Cell Migration Regulation Of Cell Differentiation Regulation Of Gene Expression Neuron Differentiation RNA Polymerase II-specific DNA-binding Transcription Factor Binding NF-kappaB Binding Signal Transduction