NTAN1 and UBR2

Number of citations of the paper that reports this interaction (PubMedID 32366662)
111

Data Source:
BioGRID (pull down, two hybrid)

		NTAN1	UBR2
Description		N-terminal asparagine amidase	ubiquitin protein ligase E3 component n-recognin 2
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm	Ubiquitin Ligase Complex Chromatin Nucleus Chromosome Cytoplasm Cytosol
	Molecular Function	Protein Binding Protein-N-terminal Asparagine Amidohydrolase Activity Hydrolase Activity	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity L-leucine Binding Histone H2A Ubiquitin Ligase Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Memory Adult Locomotory Behavior	Ubiquitin-dependent Protein Catabolic Process Reciprocal Meiotic Recombination Male Meiotic Nuclear Division Male Meiosis I Spermatogenesis Transposable Element Silencing Protein Ubiquitination Protein Catabolic Process Heterochromatin Formation Negative Regulation Of TOR Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Receptor Signaling Pathway Protein K63-linked Ubiquitination Cellular Response To L-leucine Ubiquitin-dependent Protein Catabolic Process Via The N-end Rule Pathway
Pathways			Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Body mass index ( 29273807) Femoral neck bone mineral density ( 22504420) Fruit consumption ( 32066663) Height ( 20189936 31562340) Metabolite levels ( 23823483) Plasma omega-6 polyunsaturated fatty acid levels (arachidonic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid) ( 24823311) Serum metabolite ratios in chronic kidney disease ( 29545352) Weight ( 28552196)	HDL cholesterol levels in HIV infection ( 33109212) Lung cancer in never smokers ( 28604730) Obesity-related traits ( 23251661) Serum total protein levels ( 29403010)
Interacting Genes		5 interacting genes: ATE1 MEOX2 NTAQ1 UBR1 UBR2	11 interacting genes: ATF3 CRYAA H2AC20 H2BC8 NTAN1 NTAQ1 PKN1 SUOX UBE2B UBE2D2 UBE2H
Entrez ID		123803	23304
HPRD ID		17649	09853
Ensembl ID		ENSG00000157045	ENSG00000024048
Uniprot IDs		A0A087X0T5 Q96AB6	B3KXG6 Q8IWV8
PDB IDs		6A0E 6A0F 6A0H 6A0I	3NY2 3NY3 5TDA 5TDB 5TDD 5UM3
Enriched GO Terms of Interacting Partners?		Ubiquitin-dependent Protein Catabolic Process Via The N-end Rule Pathway L-leucine Binding Cellular Response To L-leucine Response To L-leucine Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Protein K63-linked Ubiquitination Arginyl-tRNA--protein Transferase Activity Negative Regulation Of TOR Signaling Cellular Response To Amino Acid Stimulus Histone H2A Ubiquitin Ligase Activity Protein-N-terminal Glutamine Amidohydrolase Activity Protein Arginylation Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Ubiquitin Ligase Complex Response To Amino Acid Protein-N-terminal Asparagine Amidohydrolase Activity Protein Catabolic Process Protein Ubiquitination Protein Modification Process Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Regulation Of TOR Signaling Negative Regulation Of Nodal Signaling Pathway Somite Specification Post-translational Protein Modification Regulation Of Nodal Signaling Pathway Multi-pass Transmembrane Protein Insertion Into ER Membrane Multi-pass Translocon Complex Determination Of Left/right Asymmetry In Lateral Mesoderm Macromolecule Catabolic Process Protein Polyubiquitination Protein Targeting To Vacuole Involved In Autophagy Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides Segment Specification Somite Development Proteolysis Negative Regulation Of Activin Receptor Signaling Pathway Protein K27-linked Ubiquitination Ubiquitin Protein Ligase Activity Positive Regulation Of T Cell Receptor Signaling Pathway Pattern Specification Process Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Protein Metabolic Process Negative Regulation Of Signal Transduction Positive Regulation Of Antigen Receptor-mediated Signaling Pathway Male Meiosis I Reciprocal Meiotic Recombination Regulation Of Activin Receptor Signaling Pathway	Protein-N-terminal Asparagine Amidohydrolase Activity Ubiquitin Conjugating Enzyme Activity Protein K48-linked Ubiquitination Nucleus Modification-dependent Protein Catabolic Process Protein K11-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of TRAIL-activated Apoptotic Signaling Pathway Sulfite Oxidase Activity Protein Polyubiquitination Proteolysis Involved In Protein Catabolic Process Ubiquitin-protein Transferase Activity Protein-N-terminal Glutamine Amidohydrolase Activity Protein Autoubiquitination CHOP-ATF3 Complex Protein Heterodimerization Activity Post-translational Protein Modification Chromatin Organization Positive Regulation Of Reciprocal Meiotic Recombination Structural Constituent Of Chromatin Histone H3T11 Kinase Activity Molybdenum Ion Binding Protein Modification Process Nucleosome Molybdopterin Cofactor Binding Macromolecule Catabolic Process HULC Complex
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?