CNTNAP1 and NFASC

Number of citations of the paper that reports this interaction (PubMedID 11839274)
0

Data Source:
HPRD (in vitro)

		CNTNAP1	NFASC
Description		contactin associated protein 1	neurofascin
Image		No pdb structure
GO Annotations	Cellular Component	Membrane Paranodal Junction Paranode Region Of Axon Anchoring Junction Glutamatergic Synapse	Plasma Membrane Focal Adhesion Membrane Axon Paranodal Junction Node Of Ranvier Axon Initial Segment Anchoring Junction Ficolin-1-rich Granule Membrane
	Molecular Function	Protein Binding SH3 Domain Binding Signaling Receptor Activity	Protein Binding Cell-cell Adhesion Mediator Activity
	Biological Process	Protein Localization To Paranode Region Of Axon Mitochondrion Organization Cytoskeleton Organization Cell Adhesion Signal Transduction Axonogenesis Central Nervous System Development Neuronal Action Potential Propagation Central Nervous System Myelination Myelination In Peripheral Nervous System Paranodal Junction Assembly Neuron Projection Development Myelination Neuron Projection Morphogenesis Neuromuscular Process Controlling Posture Neuromuscular Process Controlling Balance Neuromuscular Process Protein Localization To Juxtaparanode Region Of Axon Regulation Of Synapse Maturation Postsynaptic Density Organization Neuromuscular Junction Development, Skeletal Muscle Fiber Paranodal Junction Maintenance	Cell Adhesion Axon Guidance Brain Development Peripheral Nervous System Development Myelination Cell-cell Adhesion
Pathways		Neurofascin interactions	Interaction between L1 and Ankyrins Neurofascin interactions Neurofascin interactions Neutrophil degranulation
Drugs
Diseases
GWAS		Breast cancer ( 29059683) Major depressive disorder ( 27777418) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Age at first sexual intercourse ( 34211149) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Blood protein levels ( 30072576) Clozapine-induced agranulocytosis ( 25187353) Dental caries ( 23064961) Diisocyanate-induced asthma ( 25918132) Disrupted circadian rhythm (low relative amplitude of rest-activity cycles) ( 30120083) General risk tolerance (MTAG) ( 30643258) High myopia ( 32428537) Mean platelet volume ( 27863252 32888494) Platelet count ( 32888494) Regular attendance at a religious group ( 29970889)
Interacting Genes		9 interacting genes: CCR4 FYN LCOR NFASC PTPRB RBM11 RHOA RTN4 SRC	12 interacting genes: ABI1 ABI2 ANK1 CNTNAP1 DCX NRCAM SCN1B SCN3B SCNN1B SDCBP SDCBP2 TNR
Entrez ID		8506	23114
HPRD ID		03825	12372
Ensembl ID		ENSG00000108797	ENSG00000163531
Uniprot IDs		P78357	A0A7P0Z4R6 B4DRH7 O94856
PDB IDs			3P3Y 3P40
Enriched GO Terms of Interacting Partners?		Cell Migration Cell Motility Positive Regulation Of Podosome Assembly Phospholipase Activator Activity Regulation Of Podosome Assembly Contractile Actin Filament Bundle Assembly Stress Fiber Assembly Neuron Migration Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Cellular Response To Platelet-derived Growth Factor Stimulus Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Stimulatory C-type Lectin Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Response To Platelet-derived Growth Factor Phospholipase Binding Cellular Response To Lectin Ephrin Receptor Binding Glial Cell Migration Cerebral Cortex Cell Migration Negative Regulation Of Inflammatory Response To Antigenic Stimulus Cell Junction Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Oxidative Stress Fc-gamma Receptor Signaling Pathway Negative Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Plasma Membrane Bounded Cell Projection Organization Telencephalon Cell Migration Regulation Of Cell Projection Organization Substrate Adhesion-dependent Cell Spreading Forebrain Cell Migration Regulation Of Reactive Oxygen Species Biosynthetic Process T Cell Costimulation Leukocyte Migration Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Cell Junction Assembly Positive Regulation Of T Cell Activation Ephrin Receptor Signaling Pathway Cellular Response To Chemical Stress Peptidyl-tyrosine Phosphorylation Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Synapse Organization Negative Regulation Of Cell-substrate Adhesion Cell Differentiation Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Ficolin-1-rich Granule Membrane Actin Filament Bundle Organization Actin Filament Bundle Assembly	Action Potential Propagation Neuronal Action Potential Propagation Cytoskeletal Anchor Activity Action Potential System Development Neuron Migration Cell Projection Organization Plasma Membrane Bounded Cell Projection Organization Sodium Channel Inhibitor Activity Sodium Channel Complex Actin-based Cell Projection Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Nervous System Development SCAR Complex Cell Projection Morphogenesis Voltage-gated Sodium Channel Complex Membrane Depolarization During Cardiac Muscle Cell Action Potential SH3 Domain Binding Filopodium Tip Neuron Projection Membrane Depolarization During Action Potential Sodium Ion Transmembrane Transport Transmembrane Transporter Binding Central Nervous System Development Regulation Of Neuron Projection Development Regulation Of Membrane Potential Cell Migration Nervous System Process Cell Junction Organization System Process Sodium Channel Regulator Activity Sodium Ion Transport Positive Regulation Of Sodium Ion Transport Neuron Projection Development Sodium Channel Activity Cardiac Muscle Cell Action Potential Involved In Contraction Cytoskeleton Organization Muscle Contraction Regulation Of Heart Rate By Cardiac Conduction Cardiac Muscle Cell Action Potential Cardiac Muscle Contraction Neuron Projection Guidance Axon Guidance Cell Motility Cardiac Conduction Neuromuscular Process Controlling Balance Regulation Of Cellular Component Organization Regulation Of Membrane Depolarization Membrane Depolarization Synapse Organization
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