LEO1 and GPRASP3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LEO1	GPRASP3
Description		LEO1 component of Paf1/RNA polymerase II complex	G protein-coupled receptor associated sorting protein family member 3
Image			No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Centrosome Cdc73/Paf1 Complex	Nucleus Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Protein Binding RNA Polymerase II C-terminal Domain Phosphoserine Binding	Protein Binding Protein Homodimerization Activity
	Biological Process	Endodermal Cell Fate Commitment Transcription Elongation By RNA Polymerase II Wnt Signaling Pathway Stem Cell Population Maintenance MRNA 3'-end Processing Positive Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II	Learning Or Memory Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Neurogenesis Positive Regulation Of Synapse Assembly Positive Regulation Of Dendritic Spine Morphogenesis
Pathways		Formation of RNA Pol II elongation complex Formation of the beta-catenin:TCF transactivating complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases
GWAS		Frailty index ( 34431594)
Interacting Genes		9 interacting genes: CSNK2A1 CTNNB1 DYRK1A ERCC6 GPRASP3 H1-2 POLR2A TCEA1 TCEA3	59 interacting genes: ANKRD11 APP AQP1 ATOSB BEX2 CATSPERT CCDC120 CDC23 CDC37 CDCA7L CT55 DDX6 DRC4 EAF1 EIF3B ENKD1 FAM124B FAM161A FAM90A1 GEM GPANK1 HOXA1 INO80B IPO5 IQUB KLHL38 L3MBTL2 LEO1 LMO1 LONRF1 MFAP1 MISP MPP1 MYO15B NRIP1 OTX1 PALS1 PHF1 PNMA5 POLR1C PPP2R5E PRKAB2 PRPF31 RCOR3 SCNM1 SH3KBP1 SMARCD1 SPANXN2 TASOR2 TCEA2 TEPSIN THOC1 TLK1 TOP3B TSGA10IP TXN2 USP2 USP20 ZNF417
Entrez ID		123169	80823
HPRD ID		11231	10028
Ensembl ID		ENSG00000166477	ENSG00000198908
Uniprot IDs		Q8WVC0	Q6PI77
PDB IDs		4M6T 6GMH 6TED 7OOP 7OPC 7OPD 7UNC 7UND 8A3Y 9EGX 9EGY 9EGZ 9EH0 9EH2
Enriched GO Terms of Interacting Partners?		DNA-templated Transcription Elongation DNA-templated Transcription Transcription Elongation By RNA Polymerase II Double-strand Break Repair Via Nonhomologous End Joining Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleic Acid Metabolic Process Transcription By RNA Polymerase II Double-strand Break Repair Via Classical Nonhomologous End Joining Regulation Of RNA Metabolic Process RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Nucleobase-containing Compound Biosynthetic Process Regulation Of DNA Recombination Negative Regulation Of DNA Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of DNA Metabolic Process Nucleus Double-strand Break Repair Negative Regulation Of DNA Repair Regulation Of Gene Expression Negative Regulation Of Double-strand Break Repair Positive Regulation Of RNA Splicing Negative Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Negative Regulation Of DNA Recombination Macromolecule Biosynthetic Process Euchromatin Negative Regulation Of Nucleobase-containing Compound Metabolic Process Glial Cell Fate Determination Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Positive Regulation Of DNA-templated Transcription, Elongation Histone H3T45 Kinase Activity Negative Regulation Of Cell Cycle Regulation Of Macromolecule Metabolic Process Regulation Of Double-strand Break Repair Via Homologous Recombination Mesenchymal Stem Cell Differentiation Positive Regulation Of Determination Of Dorsal Identity Negative Regulation Of Mitotic Cell Cycle, Embryonic Beta-catenin-ICAT Complex Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Renal Inner Medulla Development Scrib-APC-beta-catenin Complex Renal Outer Medulla Development Renal Vesicle Formation Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of Branching Involved In Lung Morphogenesis Neural Plate Development
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