TTC8 and PTPN21

		TTC8	PTPN21
Description		tetratricopeptide repeat domain 8	protein tyrosine phosphatase non-receptor type 21
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GO Annotations	Cellular Component	Fibrillar Center Cytoplasm Mitochondrion Centrosome Cytosol Cytoskeleton Plasma Membrane Cilium Membrane Photoreceptor Connecting Cilium Centriolar Satellite BBSome Ciliary Basal Body Cell Projection Ciliary Membrane Non-motile Cilium	Cytoplasm Cytoskeleton
	Molecular Function	Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity
	Biological Process	Establishment Of Planar Polarity Axon Guidance Sensory Perception Sensory Perception Of Smell Anatomical Structure Morphogenesis Protein Transport Olfactory Bulb Development Cell Projection Organization Regulation Of Protein Localization Multicellular Organism Growth Establishment Of Epithelial Cell Apical/basal Polarity Fat Cell Differentiation Establishment Of Anatomical Structure Orientation Sensory Processing Regulation Of Stress Fiber Assembly Inner Ear Receptor Cell Stereocilium Organization Camera-type Eye Photoreceptor Cell Differentiation Cilium Assembly Renal Tubule Development Protein Localization To Plasma Membrane Multi-ciliated Epithelial Cell Differentiation Non-motile Cilium Assembly	Protein Dephosphorylation
Pathways		BBSome-mediated cargo-targeting to cilium
Drugs
Diseases		Bardet-Biedl syndrome (BBS)
GWAS		Copper levels ( 26025379) Limited cutaneous systemic scleroderma ( 29293537) Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952) Obesity-related traits ( 23251661) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027)	Prudent dietary pattern ( 28644415) Suicidality in mood disorders ( 33783297) Suicide attempt severity in mood disorders ( 33783297)
Interacting Genes		1 interacting genes: PCM1	27 interacting genes: AKAP1 ATOSB BAG3 BMX CATSPER1 CWC22 ERBB4 FBXO17 GOLGA2 KIF1C MAGOHB MOB3C NEK6 NSMF PAK5 PARD6A PIBF1 QARS1 RASD1 SNX18 SRC TEC TRIM14 UBASH3B VPS26C YAP1 ZNF497
Entrez ID		123016	11099
HPRD ID		10484	04468
Ensembl ID		ENSG00000165533	ENSG00000070778
Uniprot IDs		A0A0C4DGH8 A0A0C4DGX9 A0A0C4DGY3 B3KSL8 Q86U25 Q8TAM2	Q16825
PDB IDs		6XT9	8GVL 8GVV 8GWH 8GXE 8Y8Y
Enriched GO Terms of Interacting Partners?		Interkinetic Nuclear Migration Protein-containing Complex Localization To Centriolar Satellite Intraciliary Transport Involved In Cilium Assembly Regulation Of Protein Complex Stability Microtubule Anchoring At Centrosome Pericentriolar Material Nucleus Localization Ciliary Transition Zone Microtubule Anchoring Neuronal Stem Cell Population Maintenance Non-motile Cilium Protein Localization To Centrosome Microtubule Anchoring At Microtubule Organizing Center Nuclear Migration Non-motile Cilium Assembly Protein Localization To Cytoskeleton Centrosome Cycle Social Behavior Intraciliary Transport Cytoplasmic Microtubule Organization Cytoskeleton Protein-containing Complex Localization Microtubule Organizing Center Organization Apical Part Of Cell Positive Regulation Of Intracellular Protein Transport Protein Dephosphorylation	Protein Phosphorylation Cardiac Muscle Tissue Regeneration Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Tyrosine Kinase Activity Phosphorylation Protein Autophosphorylation Peptidyl-tyrosine Phosphorylation Centriolar Satellite Tissue Regeneration Intestinal Epithelial Cell Development Protein Kinase Activity U2-type Catalytic Step 1 Spliceosome Microtubule-based Process Columnar/cuboidal Epithelial Cell Development Interleukin-6-mediated Signaling Pathway Cytoskeleton Kinase Activity Establishment Of Planar Polarity Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein ERBB2 Signaling Pathway Mitotic Spindle Organization Spindle Assembly Negative Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Polarized Epithelial Cell Differentiation Positive Regulation Of Protein Localization Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Cardiac Muscle Cell Proliferation
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