LETMD1 and APOC4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LETMD1	APOC4
Description		LETM1 domain containing 1	apolipoprotein C4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Membrane	Extracellular Region Very-low-density Lipoprotein Particle High-density Lipoprotein Particle
	Molecular Function	Protein Binding Ribosome Binding Molecular Adaptor Activity	Lipid Transporter Activity Protein Binding
	Biological Process	ATP Biosynthetic Process Phagocytosis Inflammatory Response Mitochondrion Organization Gene Expression Response To Lipopolysaccharide Toll-like Receptor 4 Signaling Pathway Non-canonical NF-kappaB Signal Transduction Regulation Of Inflammatory Response Regulation Of Phagocytosis Mitochondrial Calcium Ion Homeostasis Positive Regulation Of Cold-induced Thermogenesis Reactive Oxygen Species Biosynthetic Process	Lipid Metabolic Process Lipid Transport Lipid Storage Triglyceride Homeostasis
Pathways			VLDL assembly VLDL clearance VLDL clearance NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
Drugs
Diseases
GWAS			Alzheimer's disease (onset between ages 58 and 79) ( 30979435) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Apolipoprotein A1 levels ( 32203549) Carotid intima media thickness (maximum) ( 31801372) Carotid intima media thickness (mean) ( 31801372) Cerebrospinal AB1-42 levels in Alzheimer's disease dementia ( 29274321) Cerebrospinal AB1-42 levels in mild cognitive impairment ( 29274321) Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Cerebrospinal fluid AB1-42 levels ( 29274321) Cerebrospinal fluid p-tau levels ( 29274321) Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321) Cerebrospinal fluid t-tau levels ( 29274321) Cerebrospinal fluid t-tau levels in mild cognitive impairment ( 29274321) HDL cholesterol levels ( 32203549) Hippocampal volume ( 29274321) Hippocampal volume in Alzheimer's disease dementia ( 29274321) LDL cholesterol ( 20864672 19060906 18802019 18193044 18193043) Logical memory (delayed recall) ( 29274321) Logical memory (immediate recall) ( 29274321) Quantitative traits ( 19197348) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)
Interacting Genes		11 interacting genes: APOC1 APOC2 APOC4 APP CCR1 FBXO7 HCK RHBDD2 SH2D1A TMEM167B UBC	24 interacting genes: APOL2 BCL2L2 DIABLO GAD2 GSDMA IFI27 LETMD1 MAIP1 MICOS10 MICOS13 NFU1 PORCN RSAD2 SENP2 SNAP47 SYT16 TBC1D20 THBD TIMMDC1 TMEM14B TPRG1 UBQLN1 UBQLN2 VKORC1
Entrez ID		25875	346
HPRD ID		09978	02848
Ensembl ID		ENSG00000050426	ENSG00000267467
Uniprot IDs		A0A384P5D7 F8VP71 F8W1Z2 Q6P1Q0	P55056
PDB IDs
Enriched GO Terms of Interacting Partners?		High-density Lipoprotein Particle Very-low-density Lipoprotein Particle Acylglycerol Homeostasis Negative Regulation Of Very-low-density Lipoprotein Particle Clearance Lipoprotein Metabolic Process Triglyceride Homeostasis Chylomicron Remnant Clearance Triglyceride-rich Lipoprotein Particle Clearance Intermediate-density Lipoprotein Particle Regulation Of Phospholipid Catabolic Process Lipase Inhibitor Activity Chylomicron Phospholipid Efflux Regulation Of Endocytosis Low-density Lipoprotein Particle Negative Regulation Of Lipoprotein Particle Clearance Regulation Of Receptor-mediated Endocytosis Negative Regulation Of Cholesterol Transport Positive Regulation Of Monocyte Chemotaxis Chemical Homeostasis Molecular Function Activator Activity Plasma Lipoprotein Particle Clearance Lipid Homeostasis Positive Regulation Of Defense Response Cholesterol Efflux Negative Regulation Of Receptor-mediated Endocytosis Regulation Of Monocyte Chemotaxis Regulation Of Phospholipid Metabolic Process Plasma Lipoprotein Particle Remodeling Protein-containing Complex Remodeling Negative Regulation Of Lipid Transport Exocytosis Regulation Of Vesicle-mediated Transport Regulation Of Triglyceride Metabolic Process Regulation Of Fatty Acid Biosynthetic Process Negative Regulation Of Multicellular Organismal Process Regulation Of Lipid Catabolic Process Negative Regulation Of Phosphatidylcholine Catabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Protein Metabolic Process Homeostatic Process Regulation Of Cholesterol Transport	Virion Assembly Membrane Mitochondrion Mitochondrion Organization Mitochondrial Inner Membrane Inner Mitochondrial Membrane Organization MICOS Complex Mitochondrial Crista Junction SAM Complex MIB Complex Host-mediated Perturbation Of Viral Genome Replication Mitochondrial Membrane Cristae Formation Host-mediated Perturbation Of Viral Process Mitochondrial Outer Membrane Negative Regulation Of Platelet Activation Positive Regulation Of ERAD Pathway Mitochondrial Calcium Ion Homeostasis Host-mediated Perturbation Of Symbiont Process Mitochondrial Membrane Organization Modulation Of Process Of Another Organism Extrinsic Apoptotic Signaling Pathway Regulation Of ERAD Pathway Negative Regulation Of Phospholipid Efflux Lipoprotein Metabolic Process Negative Regulation Of Postsynaptic Membrane Organization Positive Regulation Of Lipid Transport Across Blood-brain Barrier Host-mediated Activation Of Viral Process Negative Regulation Of Lipid Transport Across Blood-brain Barrier Regulation Of Cellular Response To Very-low-density Lipoprotein Particle Stimulus Metal Chelating Activity Intermediate-density Lipoprotein Particle Clearance Positive Regulation Of Coagulation Polyubiquitin Modification-dependent Protein Binding Negative Regulation Of Store-operated Calcium Channel Activity Palmitoleoyltransferase Activity Protein Palmitoleylation Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Positive Regulation Of Response To Endoplasmic Reticulum Stress Pyroptotic Inflammatory Response 4 Iron, 4 Sulfur Cluster Binding Organelle Organization Negative Regulation Of Coagulation Negative Regulation Of Blood Coagulation Positive Regulation Of Presynaptic Membrane Organization Chylomicron Remnant Lipid Transport Involved In Lipid Storage Lipoprotein Particle Protein Binding Regulation Of Platelet Activation
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