LETMD1 and APOC2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LETMD1	APOC2
Description		LETM1 domain containing 1	apolipoprotein C2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Membrane	Extracellular Region Extracellular Space Early Endosome Very-low-density Lipoprotein Particle Low-density Lipoprotein Particle Intermediate-density Lipoprotein Particle High-density Lipoprotein Particle Spherical High-density Lipoprotein Particle Chylomicron
	Molecular Function	Protein Binding Ribosome Binding Molecular Adaptor Activity	Protein Binding Enzyme Activator Activity Lipid Binding Phospholipase Activator Activity Identical Protein Binding Phospholipase Binding Lipase Inhibitor Activity Lipoprotein Lipase Activator Activity Molecular Function Activator Activity
	Biological Process	ATP Biosynthetic Process Phagocytosis Inflammatory Response Mitochondrion Organization Gene Expression Response To Lipopolysaccharide Toll-like Receptor 4 Signaling Pathway Non-canonical NF-kappaB Signal Transduction Regulation Of Inflammatory Response Regulation Of Phagocytosis Mitochondrial Calcium Ion Homeostasis Positive Regulation Of Cold-induced Thermogenesis Reactive Oxygen Species Biosynthetic Process	Lipid Metabolic Process Lipid Transport Positive Regulation Of Triglyceride Catabolic Process Positive Regulation Of Very-low-density Lipoprotein Particle Remodeling Negative Regulation Of Very-low-density Lipoprotein Particle Clearance Lipid Catabolic Process Negative Regulation Of Cholesterol Transport Cholesterol Efflux Phospholipid Efflux Triglyceride-rich Lipoprotein Particle Remodeling Chylomicron Remodeling Very-low-density Lipoprotein Particle Remodeling Chylomicron Remnant Clearance High-density Lipoprotein Particle Clearance Lipoprotein Catabolic Process Cholesterol Homeostasis Reverse Cholesterol Transport Positive Regulation Of Fatty Acid Biosynthetic Process Negative Regulation Of Lipid Metabolic Process Negative Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Phospholipid Catabolic Process Triglyceride Homeostasis
Pathways			Chylomicron assembly Assembly of active LPL and LIPC lipase complexes Chylomicron remodeling HDL remodeling NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux Retinoid metabolism and transport Retinoid metabolism and transport
Drugs			Copper
Diseases			Hyperlipoproteinemia, type I
GWAS			Alzheimer's disease (onset between ages 58 and 79) ( 30979435) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Carotid intima media thickness (maximum) ( 31801372) Carotid intima media thickness (mean) ( 31801372) Cerebrospinal AB1-42 levels in Alzheimer's disease dementia ( 29274321) Cerebrospinal AB1-42 levels in mild cognitive impairment ( 29274321) Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Cerebrospinal fluid AB1-42 levels ( 29274321) Cerebrospinal fluid p-tau levels ( 29274321) Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321) Cerebrospinal fluid t-tau levels ( 29274321) Cerebrospinal fluid t-tau levels in mild cognitive impairment ( 29274321) Cholesterol, total ( 20686565) HDL cholesterol ( 20686565) HDL cholesterol levels ( 28334899) Hippocampal volume ( 29274321) Hippocampal volume in Alzheimer's disease dementia ( 29274321) LDL cholesterol ( 18802019 20864672 20686565 19060906 18193044) LDL cholesterol levels ( 28334899) Lipid metabolism phenotypes ( 22286219) Logical memory (delayed recall) ( 29274321) Logical memory (immediate recall) ( 29274321) Low density lipoprotein cholesterol levels ( 28548082) Quantitative traits ( 19197348) Total cholesterol levels ( 28548082 28334899) Triglyceride levels ( 28334899) Triglycerides ( 20686565) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)
Interacting Genes		11 interacting genes: APOC1 APOC2 APOC4 APP CCR1 FBXO7 HCK RHBDD2 SH2D1A TMEM167B UBC	28 interacting genes: APOL2 BCL2L2 CFTR CRYAB DIABLO GAD2 GSDMA IFI27 LETMD1 LPL MAIP1 MICOS10 MICOS13 NFU1 PORCN RSAD2 SENP2 SNAP47 SNCA SYT16 TBC1D20 THBD TIMMDC1 TMEM14B TPRG1 TTPA UBQLN1 UBQLN2
Entrez ID		25875	344
HPRD ID		09978	07457
Ensembl ID		ENSG00000050426	ENSG00000234906
Uniprot IDs		A0A384P5D7 F8VP71 F8W1Z2 Q6P1Q0	A0A024R0T9 P02655
PDB IDs			1BY6 1I5J 1O8T 1SOH
Enriched GO Terms of Interacting Partners?		High-density Lipoprotein Particle Very-low-density Lipoprotein Particle Acylglycerol Homeostasis Negative Regulation Of Very-low-density Lipoprotein Particle Clearance Lipoprotein Metabolic Process Triglyceride Homeostasis Chylomicron Remnant Clearance Triglyceride-rich Lipoprotein Particle Clearance Intermediate-density Lipoprotein Particle Regulation Of Phospholipid Catabolic Process Lipase Inhibitor Activity Chylomicron Phospholipid Efflux Regulation Of Endocytosis Low-density Lipoprotein Particle Negative Regulation Of Lipoprotein Particle Clearance Regulation Of Receptor-mediated Endocytosis Negative Regulation Of Cholesterol Transport Positive Regulation Of Monocyte Chemotaxis Chemical Homeostasis Molecular Function Activator Activity Plasma Lipoprotein Particle Clearance Lipid Homeostasis Positive Regulation Of Defense Response Cholesterol Efflux Negative Regulation Of Receptor-mediated Endocytosis Regulation Of Monocyte Chemotaxis Regulation Of Phospholipid Metabolic Process Plasma Lipoprotein Particle Remodeling Protein-containing Complex Remodeling Negative Regulation Of Lipid Transport Exocytosis Regulation Of Vesicle-mediated Transport Regulation Of Triglyceride Metabolic Process Regulation Of Fatty Acid Biosynthetic Process Negative Regulation Of Multicellular Organismal Process Regulation Of Lipid Catabolic Process Negative Regulation Of Phosphatidylcholine Catabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Protein Metabolic Process Homeostatic Process Regulation Of Cholesterol Transport	Mitochondrion Mitochondrion Organization Mitochondrial Inner Membrane Membrane Very-low-density Lipoprotein Particle Clearance Mitochondrial Outer Membrane Mitochondrial Membrane Organization Inner Mitochondrial Membrane Organization Mitochondrial Crista Junction Lipoprotein Particle Binding Virion Assembly Very-low-density Lipoprotein Particle Remodeling Positive Regulation Of Amyloid-beta Clearance Negative Regulation Of Transport MICOS Complex Triglyceride-rich Lipoprotein Particle Remodeling SAM Complex MIB Complex Organelle Organization Host-mediated Perturbation Of Viral Genome Replication Cristae Formation Regulation Of Transport Chylomicron Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Amyloid Fibril Formation Mitochondrial Membrane Host-mediated Perturbation Of Viral Process Regulation Of Vesicle-mediated Transport Neutral Lipid Metabolic Process Heparan Sulfate Proteoglycan Binding Regulation Of Amyloid Fibril Formation Negative Regulation Of Platelet Activation Synaptic Vesicle Priming Positive Regulation Of ERAD Pathway Very-low-density Lipoprotein Particle High-density Lipoprotein Particle Remodeling Regulation Of Amyloid-beta Clearance Calcium Ion Homeostasis Mitochondrial Calcium Ion Homeostasis Protein Binding Membrane Organization Host-mediated Perturbation Of Symbiont Process Regulation Of ERAD Pathway Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Phospholipid Efflux Lipoprotein Metabolic Process Sterol Metabolic Process Monoatomic Ion Homeostasis Negative Regulation Of Postsynaptic Membrane Organization Positive Regulation Of Lipid Transport Across Blood-brain Barrier
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