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ANAPC16 and RBBP6
Number of citations of the paper that reports this interaction (PubMedID
18851979
)
0
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
ANAPC16
RBBP6
Description
anaphase promoting complex subunit 16
RB binding protein 6, ubiquitin ligase
Image
GO Annotations
Cellular Component
Chromosome, Centromeric Region
Kinetochore
Nucleus
Nucleoplasm
Anaphase-promoting Complex
Chromosome
Cytoplasm
Cytosol
Nucleus
Chromosome
Nucleolus
Cytoplasm
Centrosome
Cytosol
Cytoskeleton
Nuclear Speck
Protein-containing Complex
Molecular Function
Protein Binding
Nucleic Acid Binding
RNA Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Transferase Activity
Protein Kinase Binding
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Biological Process
Regulation Of Mitotic Cell Cycle
Protein Ubiquitination
Anaphase-promoting Complex-dependent Catabolic Process
Cell Division
Regulation Of Meiotic Cell Cycle
Protein K48-linked Ubiquitination
Protein K11-linked Ubiquitination
Protein Branched Polyubiquitination
In Utero Embryonic Development
DNA Replication
Regulation Of DNA Replication
MRNA Processing
Ubiquitin-dependent Protein Catabolic Process
DNA Damage Response
Protein Ubiquitination
Multicellular Organism Growth
Embryonic Organ Development
Somite Development
Pathways
Inactivation of APC/C via direct inhibition of the APC/C complex
APC/C:Cdc20 mediated degradation of Cyclin B
Autodegradation of Cdh1 by Cdh1:APC/C
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Regulation of APC/C activators between G1/S and early anaphase
APC/C:Cdc20 mediated degradation of mitotic proteins
Phosphorylation of the APC/C
APC-Cdc20 mediated degradation of Nek2A
Separation of Sister Chromatids
Senescence-Associated Secretory Phenotype (SASP)
Assembly of the pre-replicative complex
CDK-mediated phosphorylation and removal of Cdc6
Transcriptional Regulation by VENTX
Aberrant regulation of mitotic exit in cancer due to RB1 defects
RHOBTB1 GTPase cycle
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Height (
31562340
)
Refractive error (
32231278
)
Adult body size (
32376654
)
Body mass index (
28892062
)
Body size at age 10 (
32376654
)
Brain structure (
20171287
)
Chronotype (
30696823
)
Low hand grip strength (60 years and older) (EWGSOP) (
33510174
)
Obesity-related traits (
23251661
)
Pulse pressure (
27841878
)
Systolic blood pressure (
27841878
)
Interacting Genes
2 interacting genes:
HSF2BP
RBBP6
44 interacting genes:
ACOT13
AGO2
ANAPC16
APOH
ASGR1
CAPZA2
CASK
CD81
CLK1
CPSF3
EIF4ENIF1
ETS1
EVA1C
FAAP24
FBXO7
GLUL
GRB2
HP
KHDRBS3
LINC00305
LRCH4
MAD2L2
MDM2
MIR19A
MIR19B1
NDUFB9
NEK6
PIAS1
PLG
RB1
RBP4
RCC1L
RPS14
SMN1
SPP1
TFIP11
TP53
TPT1
UBE2I
UPF3B
VAV2
YBX1
ZBTB38
ZFYVE9
Entrez ID
119504
5930
HPRD ID
12554
02964
Ensembl ID
ENSG00000166295
ENSG00000122257
Uniprot IDs
A0A087WUN5
C5H3H2
Q96DE5
Q7Z6E9
PDB IDs
4RG6
4RG9
4UI9
5A31
5G04
5G05
5KHR
5KHU
5L9T
5L9U
5LCW
6Q6G
6Q6H
6TLJ
6TM5
6TNT
8PKP
8TAR
8TAU
9GAW
2C7H
2YSA
2YUR
3ZTG
6E5X
Enriched GO Terms of Interacting Partners
?
Negative Regulation Of Developmental Process
PML Body
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Developmental Process
Regulation Of Cell Differentiation
Regulation Of Mitotic Cell Cycle
Negative Regulation Of Cell Differentiation
SUMO Transferase Activity
Regulation Of Cell Cycle Phase Transition
Cellular Response To Actinomycin D
Regulation Of MRNA Metabolic Process
Protein Domain Specific Binding
Negative Regulation Of Multicellular Organismal Process
Positive Regulation Of RNA Metabolic Process
Nucleoplasm
Response To Actinomycin D
Positive Regulation Of MRNA Metabolic Process
Negative Regulation Of Cardiac Epithelial To Mesenchymal Transition
Disordered Domain Specific Binding
Positive Regulation Of Muscle Cell Differentiation
Positive Regulation Of Metabolic Process
Regulation Of Muscle Cell Differentiation
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Cellular Response To UV-C
Glial Cell Apoptotic Process
Negative Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Locomotion
Positive Regulation Of Catabolic Process
Negative Regulation Of Matrix Metallopeptidase Secretion
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Response To Antibiotic
Regulation Of Cell Cycle G1/S Phase Transition
Ubiquitin Protein Ligase Binding
Regulation Of Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Protein Metabolic Process
MiRNA-mediated Gene Silencing By MRNA Destabilization
Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development
Regulation Of MRNA Stability
Regulation Of Endothelial Cell Migration
Regulation Of Metabolic Process
Regulation Of Immune System Process
Regulation Of Cell Migration
Positive Regulation Of B Cell Receptor Signaling Pathway
Regulation Of Multicellular Organismal Development
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Regulation Of RNA Stability
Negative Regulation Of Mitotic Cell Cycle
Negative Regulation Of Epithelial To Mesenchymal Transition
Positive Regulation Of MRNA Catabolic Process
MiRNA-mediated Post-transcriptional Gene Silencing
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