BCLAF1 and H19

Number of citations of the paper that reports this interaction (PubMedID 37298108)
45

Data Source:
BioGRID (unspecified method)

		BCLAF1	H19
Description		BCL2 associated transcription factor 1	H19 imprinted maternally expressed transcript
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mediator Complex Nuclear Speck
	Molecular Function	DNA Binding Transcription Coregulator Activity RNA Binding Protein Binding
	Biological Process	Apoptotic Process DNA Damage Response Positive Regulation Of Apoptotic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Leukemia Inhibitory Factor Positive Regulation Of DNA-templated Transcription Initiation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways
Drugs
Diseases			Russell-Silver syndrome; Silver-Russell syndrome Beckwith-Wiedemann syndrome
GWAS			Celiac disease ( 23936387) Creatinine levels ( 29403010) Diastolic blood pressure ( 27841878) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) DNA methylation (parent-of-origin) ( 23725790) DNA methylation (variation) ( 23725790) Estimated glomerular filtration rate ( 30604766) Glomerular filtration rate ( 29403010) Hypertension ( 30487518) Pulse pressure ( 27841878) Squamous cell lung carcinoma ( 28604730) Systolic blood pressure ( 27841878 28135244) Systolic blood pressure (cigarette smoking interaction) ( 29455858)
Interacting Genes		16 interacting genes: BCL2 BCL2L1 CEBPA CHD1 CLK1 CSNK2A1 EMD H19 LEMD3 OGT PIN1 RNF10 SRPK2 USP7 WEE2-AS1 YWHAG	21 interacting genes: BCLAF1 DDX5 DSP ESRP1 FMR1 IFIT5 ILF2 MYO1D NSD2 PCCA PCCB PPP1R3E PRKRA SERBP1 SRSF10 SRSF8 SRSF9 SSB STON2 TPM1 U2SURP
Entrez ID		9774	283120
HPRD ID		16544
Ensembl ID		ENSG00000029363	ENSG00000130600
Uniprot IDs		E9PK91 Q9NYF8
PDB IDs		7RJN 7RJR
Enriched GO Terms of Interacting Partners?		Dendritic Cell Apoptotic Process Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Negative Regulation Of Catabolic Process Negative Regulation Of Cell Communication Symbiont-mediated Disruption Of Host Cell PML Body Negative Regulation Of Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Intracellular Signal Transduction Regulation Of Protein Localization Negative Regulation Of Translational Initiation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process BH3 Domain Binding Regulation Of Protein Stability Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Negative Regulation Of Dendritic Cell Apoptotic Process Bcl-2 Family Protein Complex Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process TORC1 Signaling Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Intracellular Signal Transduction Nucleus Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Response To Nutrient Levels Protein Stabilization TOR Signaling Cellular Response To Nutrient Levels Protein Localization To Vacuole Nuclear Membrane Regulation Of Cellular Localization Regulation Of TORC1 Signaling Negative Regulation Of Autophagy Regulation Of Translational Initiation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Anoikis Negative Regulation Of Protein Metabolic Process Programmed Cell Death Involved In Cell Development Regulation Of Signal Transduction By P53 Class Mediator Sin3-type Complex Release Of Cytochrome C From Mitochondria Regulation Of Protein Metabolic Process Regulation Of Anoikis Regulation Of Cell Cycle Cellular Response To Stress Negative Regulation Of Proteolysis Regulation Of Autophagy Protein Modification Process Regulation Of Proteolysis	RNA Binding Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Binding Regulation Of RNA Splicing Nucleic Acid Binding Regulation Of MRNA Splicing, Via Spliceosome RNA Processing Regulation Of MRNA Processing Propionyl-CoA Carboxylase Activity Regulation Of MRNA Metabolic Process Poly(U) RNA Binding RNA Splicing MRNA Metabolic Process MRNA Processing Short-chain Fatty Acid Catabolic Process Ribonucleoprotein Complex SiRNA Binding Sequence-specific MRNA Binding Nuclear Speck Translation Repressor Activity Short-chain Fatty Acid Metabolic Process Nuclear-transcribed MRNA Catabolic Process Negative Regulation Of Gene Expression Regulation Of Viral Life Cycle Catalytic Complex Negative Regulation Of MRNA Splicing, Via Spliceosome Branched-chain Amino Acid Metabolic Process MRNA Catabolic Process Negative Regulation Of RNA Splicing MRNA 3'-UTR Binding Regulation Of Viral Process Negative Regulation Of Macromolecule Biosynthetic Process Nucleolus MRNA Splice Site Recognition MiRNA Processing Negative Regulation Of Biosynthetic Process RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process MiRNA Transcription Positive Regulation Of Intracellular Transport Of Viral Material Ligase Activity, Forming Carbon-carbon Bonds Nuclear Histone MRNA Catabolic Process Positive Regulation Of Heart Rate By Epinephrine Regulation Of Inner Ear Auditory Receptor Cell Fate Specification Ventricular Cardiac Muscle Tissue Morphogenesis Regulation Of Primary Metabolic Process RNA Catabolic Process Nucleic Acid Metabolic Process Protein-RNA Complex Assembly Negative Regulation Of Macromolecule Metabolic Process
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