SFR1 and NMI

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		SFR1	NMI
Description		SWI5 dependent homologous recombination repair protein 1	N-myc and STAT interactor
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Centrosome Swi5-Sfr1 Complex	Extracellular Region Extracellular Space Nucleus Nucleoplasm Cytoplasm Cytosol Membrane
	Molecular Function	Transcription Coactivator Activity Protein Binding	Protein Binding Identical Protein Binding
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Damage Response Positive Regulation Of DNA-templated Transcription Cellular Response To Estrogen Stimulus	Macrophage Activation Involved In Immune Response Immune System Process Cell Surface Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Cell Population Proliferation Response To Virus Negative Regulation Of Type I Interferon Production Negative Regulation Of Interferon-alpha Production Negative Regulation Of Interferon-beta Production Toll-like Receptor 4 Signaling Pathway Innate Immune Response Regulation Of Innate Immune Response Positive Regulation Of Innate Immune Response Negative Regulation Of Innate Immune Response Positive Regulation Of Inflammatory Response Protein K48-linked Ubiquitination Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Protein K48-linked Ubiquitination
Pathways			SARS-CoV-1 activates/modulates innate immune responses
Drugs
Diseases
GWAS
Interacting Genes		14 interacting genes: CDC5L CEP70 DTNBP1 EXOC1 FBXO7 HMBOX1 MRFAP1L1 NDC80 NMI RAD51 RINT1 SWI5 TFIP11 TRAF3IP1	57 interacting genes: ANKRD13C-DT BRAT1 BRCA1 BRMS1 C1orf216 CDKN2A CDKN2D CNKSR3 CNOT7 COPS7B CYP2E1 EMILIN1 EXOSC5 GCSH GOLGA8EP HDDC3 HGS HOXC9 HSPA8 HSPH1 IFI35 KDM1A LCA5L LSM4 MAD2L1BP MCPH1 MORF4L1 MTMR6 MTMR9 MYC MYCN MYOM3 NECAP2 POMZP3 PSMA1 RYBP SCEL SFR1 SH3GLB2 SINHCAF SNAPC5 SOX10 STAT1 STAT3 STAT4 STAT5A STAT5B STAT6 THAP8 TRAF5 TRIM72 TRIP12 TUBA3C TUBA3E TXLNA TXLNB UBE2I
Entrez ID		119392	9111
HPRD ID		12590	04632
Ensembl ID		ENSG00000156384	ENSG00000123609
Uniprot IDs		Q86XK3	Q13287
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Negative Regulation Of Cell Cycle Process Telomere Maintenance Negative Regulation Of Interferon-beta Production Negative Regulation Of Cell Cycle Chromosome Organization Centrosome Telomere Organization DNA Metabolic Process Regulation Of Cell Cycle Process Identical Protein Binding DNA Damage Response Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Mitotic Cell Cycle Phase Transition Chromosome, Telomeric Region Cytoplasm Response To Glucoside Negative Regulation Of Type I Interferon Production Kinetochore Adaptor Activity Negative Regulation Of Mitotic Cell Cycle Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Telomere-telomerase Complex Assembly Regulation Of Interferon-beta Production Regulation Of Cell Cycle Cilium Assembly Response To Stress Meiosis I Cell Cycle Process Mitotic Recombination-dependent Replication Fork Processing DNA Strand Exchange Activity Cellular Response To Ionizing Radiation Presynaptic Intermediate Filament Cytoskeleton G2/MI Transition Of Meiotic Cell Cycle Spliceosomal Complex Disassembly Cilium Organization Positive Regulation Of Glutamate Neurotransmitter Secretion In Response To Membrane Depolarization Swi5-Sfr1 Complex Organelle Organization Negative Regulation Of Cellular Component Organization Catalytic Step 2 Spliceosome Nuclear Division Positive Regulation Of Protein K48-linked Ubiquitination Regulation Of Mitotic Cell Cycle Phase Transition Organelle Assembly U2-type Post-mRNA Release Spliceosomal Complex Lewy Body Core Dsl1/NZR Complex	Nucleoplasm Cell Surface Receptor Signaling Pathway Via JAK-STAT Growth Hormone Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Signaling Pathway Via STAT Growth Hormone Receptor Signaling Pathway Interleukin-9-mediated Signaling Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Cell Population Proliferation RNA Polymerase II Transcription Regulator Complex Negative Regulation Of RNA Metabolic Process Negative Regulation Of Developmental Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nucleic Acid Metabolic Process Regulation Of Programmed Cell Death Regulation Of Erythrocyte Differentiation Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Cell Population Proliferation Development Of Secondary Female Sexual Characteristics Development Of Secondary Male Sexual Characteristics DNA-binding Transcription Factor Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Sin3-type Complex Regulation Of Apoptotic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Activity Positive Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cell Differentiation DNA-templated Transcription Positive Regulation Of Mesenchymal Cell Proliferation Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Mitotic Cell Cycle Negative Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Development Of Secondary Sexual Characteristics Positive Regulation Of Gene Expression Regulation Of Myeloid Cell Apoptotic Process Positive Regulation Of Metabolic Process
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