NMI and TRIM72

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NMI	TRIM72
Description		N-myc and STAT interactor	tripartite motif containing 72
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Nucleoplasm Cytoplasm Cytosol Membrane	Cytoplasm Plasma Membrane Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Sarcolemma
	Molecular Function	Protein Binding Identical Protein Binding	Phosphatidylserine Binding Protein Binding Zinc Ion Binding Transferase Activity Mitogen-activated Protein Kinase Kinase Kinase Binding Ubiquitin Conjugating Enzyme Binding Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Macrophage Activation Involved In Immune Response Immune System Process Cell Surface Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Cell Population Proliferation Response To Virus Negative Regulation Of Type I Interferon Production Negative Regulation Of Interferon-alpha Production Negative Regulation Of Interferon-beta Production Toll-like Receptor 4 Signaling Pathway Innate Immune Response Regulation Of Innate Immune Response Positive Regulation Of Innate Immune Response Negative Regulation Of Innate Immune Response Positive Regulation Of Inflammatory Response Protein K48-linked Ubiquitination Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Protein K48-linked Ubiquitination	Plasma Membrane Repair Muscle System Process Exocytosis Muscle Organ Development Negative Regulation Of Myotube Differentiation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Innate Immune Response Negative Regulation Of Insulin Receptor Signaling Pathway Protein Homooligomerization
Pathways		SARS-CoV-1 activates/modulates innate immune responses	Smooth Muscle Contraction Smooth Muscle Contraction
Drugs
Diseases
GWAS
Interacting Genes		57 interacting genes: ANKRD13C-DT BRAT1 BRCA1 BRMS1 C1orf216 CDKN2A CDKN2D CNKSR3 CNOT7 COPS7B CYP2E1 EMILIN1 EXOSC5 GCSH GOLGA8EP HDDC3 HGS HOXC9 HSPA8 HSPH1 IFI35 KDM1A LCA5L LSM4 MAD2L1BP MCPH1 MORF4L1 MTMR6 MTMR9 MYC MYCN MYOM3 NECAP2 POMZP3 PSMA1 RYBP SCEL SFR1 SH3GLB2 SINHCAF SNAPC5 SOX10 STAT1 STAT3 STAT4 STAT5A STAT5B STAT6 THAP8 TRAF5 TRIM72 TRIP12 TUBA3C TUBA3E TXLNA TXLNB UBE2I	19 interacting genes: ABI2 C1orf216 GSK3B INSR IRS1 MED21 MZT1 NMI RAC1 RIPK1 SMARCD1 TCF12 TRIM32 UBE2D1 UBE2H UBE2I UBE2N VSIG4 ZNF655
Entrez ID		9111	493829
HPRD ID		04632	17412
Ensembl ID		ENSG00000123609	ENSG00000177238
Uniprot IDs		Q13287	Q6ZMU5
PDB IDs			3KB5 7XT2 7Y4S
Enriched GO Terms of Interacting Partners?		Nucleoplasm Cell Surface Receptor Signaling Pathway Via JAK-STAT Growth Hormone Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Signaling Pathway Via STAT Growth Hormone Receptor Signaling Pathway Interleukin-9-mediated Signaling Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Cell Population Proliferation RNA Polymerase II Transcription Regulator Complex Negative Regulation Of RNA Metabolic Process Negative Regulation Of Developmental Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nucleic Acid Metabolic Process Regulation Of Programmed Cell Death Regulation Of Erythrocyte Differentiation Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Cell Population Proliferation Development Of Secondary Female Sexual Characteristics Development Of Secondary Male Sexual Characteristics DNA-binding Transcription Factor Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Sin3-type Complex Regulation Of Apoptotic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Activity Positive Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cell Differentiation DNA-templated Transcription Positive Regulation Of Mesenchymal Cell Proliferation Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Mitotic Cell Cycle Negative Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Development Of Secondary Sexual Characteristics Positive Regulation Of Gene Expression Regulation Of Myeloid Cell Apoptotic Process Positive Regulation Of Metabolic Process	Protein Modification Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Polyubiquitination Regulation Of Macromolecule Biosynthetic Process Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Protein Ubiquitination Positive Regulation Of Protein Modification Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Protein Polyubiquitination Protein Modification By Small Protein Conjugation Ubiquitin Conjugating Enzyme Activity Insulin Receptor Complex Positive Regulation Of Post-translational Protein Modification Regulation Of Glycogen Metabolic Process Protein Polyubiquitination Positive Regulation Of Protein Metabolic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Post-translational Protein Modification Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Protein Ubiquitination Positive Regulation Of Metabolic Process Positive Regulation Of Cell Communication Regulation Of Protein Modification Process Positive Regulation Of Signaling Regulation Of Neuron Differentiation Regulation Of Protein Ubiquitination Regulation Of Primary Metabolic Process Protein Metabolic Process Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Immune System Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Macromolecule Catabolic Process Insulin Receptor Signaling Pathway Signaling Adaptor Activity TOR Signaling Regulation Of Metabolic Process Regulation Of Cell Projection Assembly Negative Regulation Of TOR Signaling Regulation Of DNA-templated Transcription Negative Regulation Of Intracellular Signal Transduction Regulation Of Post-translational Protein Modification Regulation Of RNA Biosynthetic Process Insulin-like Growth Factor Receptor Binding Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
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