TWIST2 and TCF12

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		TWIST2	TCF12
Gene Name		twist family bHLH transcription factor 2	transcription factor 12
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Transcription Factor Complex Cytoplasm	Nuclear Chromatin Nucleus Cytoplasm RNA Polymerase II Transcription Factor Complex
	Molecular Function	RNA Polymerase II Transcription Factor Binding Transcription Factor Activity DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein Domain Specific Binding Protein Dimerization Activity	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Enhancer Binding BHLH Transcription Factor Binding Transcription Regulatory Region DNA Binding SMAD Binding Protein Heterodimerization Activity E-box Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Osteoblast Differentiation Transcription From RNA Polymerase II Promoter Negative Regulation Of Cell Proliferation Positive Regulation Of Keratinocyte Proliferation Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Apoptotic Process Negative Regulation Of DNA Binding Negative Regulation Of Myeloid Cell Differentiation Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Transcription, DNA-templated Embryonic Cranial Skeleton Morphogenesis Face Morphogenesis Cornea Development In Camera-type Eye	Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Immune Response Muscle Organ Development Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways			CDO in myogenesis Myogenesis
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: MEF2C SREBF1 TCF12 TCF4	48 interactors: ARMC8 ASCL4 BMF C16orf45 C1orf109 C6orf165 CDKN2C CRCP CREBBP DGCR6 EDRF1 EP300 HAND1 HEXIM2 HOPX ID1 ID2 ID3 LYSMD1 MAPKBP1 MLLT6 MORN4 MSC NAGK NEUROG3 OLIG3 OSGIN1 PRSS23 PSMA1 PTF1A QARS RNASEL RUNX1T1 SOX10 SOX8 SPG21 SRI STAT5A STK16 TAF4 TAL2 TBP TCF23 TCF3 TRIM72 TSNAX TWIST2 VPS28
Entrez ID		117581	6938
HPRD ID		09616	02725
Ensembl ID		ENSG00000233608	ENSG00000140262
Uniprot IDs		Q8WVJ9	B4E1W1 F5GY10 Q99081
PDB IDs			2KNH 4JOL
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Triglyceride Biosynthetic Process Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Regulation Of Triglyceride Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Neurogenesis Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cell Development Positive Regulation Of Lipid Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Muscle Structure Development Positive Regulation Of Protein Binding Regulation Of Neuron Differentiation Regulation Of Skeletal Muscle Tissue Development Regulation Of Secretion Transcription, DNA-templated Regulation Of Neurogenesis Tube Development Regulation Of Organ Growth RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Binding Regulation Of Cell Development Positive Regulation Of Cell Differentiation Response To Glucose Transcription From RNA Polymerase II Promoter Regulation Of Striated Muscle Tissue Development Regulation Of Lipid Biosynthetic Process Cellular Response To Starvation Regulation Of Protein Binding Organ Development Regulation Of Heart Contraction Catenin Import Into Nucleus Primary Heart Field Specification Sinoatrial Valve Morphogenesis Regulation Of Synaptic Activity Cellular Response To Trichostatin A Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Cellular Localization Cellular Response To Nutrient Levels Response To Starvation RNA Metabolic Process Response To Carbohydrate Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Insulin Secretion	Gene Expression Transcription, DNA-templated RNA Metabolic Process RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Gene Expression Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process Organ Development Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Multicellular Organismal Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Developmental Process Regulation Of Transcription, DNA-templated Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process System Development Transcription From RNA Polymerase II Promoter Biosynthetic Process Anatomical Structure Development Regulation Of DNA Binding Regulation Of Binding Negative Regulation Of DNA Binding Positive Regulation Of Transcription, DNA-templated Muscle Organ Development Central Nervous System Development Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Muscle Structure Development Cell Differentiation Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Cell Differentiation Negative Regulation Of Binding Rhythmic Process Regulation Of Cellular Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Tagcloud ?		aberrant acquire assessing biomarker cdk4 cervical contributions coupling defense emt federation gynecology initially invasion invasivity isoform mesenchymal metastasis motility obstetrics oncogenic overriding prognosis regulating senescence similarities undergo	cadherin cascade cd91 connexin consistently crc drastically ectopic efficiently enhancement facilitated fibronectin gap hsp90alpha ikappabalpha ikkalpha ikks invasion junction knocked mesenchymal migration motifs outgrowths repressed rhsp90alpha secreted spherical spreading
Tagcloud (Difference) ?		aberrant acquire assessing biomarker cdk4 cervical contributions coupling defense emt federation gynecology initially invasivity isoform metastasis motility obstetrics oncogenic overriding prognosis regulating senescence similarities undergo	cadherin cascade cd91 connexin consistently crc drastically ectopic efficiently enhancement facilitated fibronectin gap hsp90alpha ikappabalpha ikkalpha ikks junction knocked migration motifs outgrowths repressed rhsp90alpha secreted spherical spreading
Tagcloud (Intersection) ?		invasion mesenchymal