TWIST2

Description		twist family bHLH transcription factor 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Protein Dimerization Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Cell Differentiation Positive Regulation Of Cell Migration Developmental Process Negative Regulation Of Osteoblast Differentiation Negative Regulation Of DNA-templated Transcription
Pathways		Transcriptional regulation by RUNX2 Negative Regulation of CDH1 Gene Transcription
Drugs
Diseases
GWAS		Blond vs. brown/black hair color ( 30531825) Chronic obstructive pulmonary disease ( 30804561) Male-pattern baldness ( 27182965 28196072 29146897) Morning person ( 30696823) Pancreas volume ( 34128465) Rosacea symptom severity ( 29771307) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		7 interacting genes: CRK FERD3L GLIS2 MEF2C PLCG2 SREBF1 TCF4
Entrez ID		117581
HPRD ID		09616
Ensembl ID		ENSG00000233608
Uniprot IDs		Q8WVJ9
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding Cellular Developmental Process RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Response To Yeast DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Neuron Differentiation Regulation Of Transcription By RNA Polymerase II Cell Differentiation Involved In Kidney Development Protein Tyrosine Kinase Binding Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Phosphotyrosine Residue Binding Regulation Of Primary Metabolic Process Developmental Process B Cell Receptor Signaling Pathway Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Smooth Muscle Cell Migration Regulation Of RNA Metabolic Process Response To Fungus Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Macromolecule Metabolic Process Scaffold Protein Binding Response To Transforming Growth Factor Beta Cellular Response To Hormone Stimulus Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Cellular Response To Calcium Ion Sinoatrial Valve Morphogenesis DNA Binding Chromatin Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of MAPK Cascade Regulation Of Metabolic Process Positive Regulation Of Neuron Differentiation Cellular Response To Lipid Helper T Cell Diapedesis Protein Phosphorylated Amino Acid Binding Response To Cholecystokinin Muscle Cell Fate Determination Cell Differentiation Nephron Tubule Epithelial Cell Differentiation Cellular Response To Trichostatin A Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cerebellar Neuron Development Positive Regulation Of Macrophage Apoptotic Process
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