TWIST2 and MEF2C

Number of citations of the paper that reports this interaction (PMID 11809751)
13

Data Source:
HPRD (in vivo)

		TWIST2	MEF2C
Gene Name		twist family bHLH transcription factor 2	myocyte enhancer factor 2C
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Transcription Factor Complex Cytoplasm	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck Intracellular Membrane-bounded Organelle Protein Complex
	Molecular Function	RNA Polymerase II Transcription Factor Binding Transcription Factor Activity DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein Domain Specific Binding Protein Dimerization Activity	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity RNA Polymerase II Core Promoter Sequence-specific DNA Binding Transcription Factor Activity Core Promoter Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding AT DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Activating Transcription Factor Binding MiRNA Binding Histone Deacetylase Binding Transcription Regulatory Region DNA Binding Protein Heterodimerization Activity HMG Box Domain Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Osteoblast Differentiation Transcription From RNA Polymerase II Promoter Negative Regulation Of Cell Proliferation Positive Regulation Of Keratinocyte Proliferation Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Apoptotic Process Negative Regulation Of DNA Binding Negative Regulation Of Myeloid Cell Differentiation Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Transcription, DNA-templated Embryonic Cranial Skeleton Morphogenesis Face Morphogenesis Cornea Development In Camera-type Eye	Negative Regulation Of Transcription From RNA Polymerase II Promoter MAPK Cascade Blood Vessel Development Osteoblast Differentiation Neuron Migration B Cell Homeostasis Heart Looping Endochondral Ossification Blood Vessel Remodeling Chondrocyte Differentiation Toll-like Receptor Signaling Pathway Germinal Center Formation Regulation Of Germinal Center Formation MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Response To Ischemia Primary Heart Field Specification Secondary Heart Field Specification Outflow Tract Morphogenesis Sinoatrial Valve Morphogenesis Cardiac Ventricle Formation Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Apoptotic Process Humoral Immune Response Nervous System Development Heart Development Muscle Organ Development Skeletal Muscle Tissue Development Muscle Cell Fate Determination Learning Or Memory Response To Virus Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Alkaline Phosphatase Activity Neural Crest Cell Differentiation Cardiac Muscle Hypertrophy In Response To Stress Myotube Differentiation Neuron Differentiation Platelet Formation Monocyte Differentiation Negative Regulation Of Ossification Melanocyte Differentiation Positive Regulation Of Bone Mineralization Positive Regulation Of B Cell Proliferation Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Cellular Response To Drug Cellular Response To Trichostatin A Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway B Cell Proliferation Muscle Cell Differentiation Positive Regulation Of MAP Kinase Activity Regulation Of Neuron Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Innate Immune Response Regulation Of Megakaryocyte Differentiation Positive Regulation Of Myoblast Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Neurotransmitter Secretion Neurotrophin TRK Receptor Signaling Pathway Regulation Of Synaptic Plasticity Positive Regulation Of Skeletal Muscle Tissue Development Neuron Development Cell Morphogenesis Involved In Neuron Differentiation Embryonic Viscerocranium Morphogenesis Negative Regulation Of Epithelial Cell Proliferation B Cell Receptor Signaling Pathway Smooth Muscle Cell Differentiation Positive Regulation Of Muscle Cell Differentiation Stress-activated MAPK Cascade Regulation Of Synapse Assembly Regulation Of Synaptic Transmission, Glutamatergic Ventricular Cardiac Muscle Cell Differentiation Palate Development Regulation Of Synaptic Activity Positive Regulation Of Cardiac Muscle Cell Proliferation Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Sarcomere Organization Cartilage Morphogenesis Regulation Of Dendritic Spine Development Renal Tubule Morphogenesis Cellular Response To Lipopolysaccharide Cellular Response To Calcium Ion Cellular Response To Parathyroid Hormone Stimulus Cellular Response To Fluid Shear Stress Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Cell Proliferation In Bone Marrow Glomerulus Morphogenesis Nephron Tubule Epithelial Cell Differentiation Positive Regulation Of Protein Homodimerization Activity Positive Regulation Of Macrophage Apoptotic Process Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity Positive Regulation Of Cardiac Muscle Cell Differentiation Positive Regulation Of Behavioral Fear Response Epithelial Cell Proliferation Involved In Renal Tubule Morphogenesis Positive Regulation Of Skeletal Muscle Cell Differentiation
Pathways			Organelle biogenesis and maintenance Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade ERK/MAPK targets Innate Immune System Signalling by NGF CDO in myogenesis TRIF-mediated TLR3/TLR4 signaling MAP kinase activation in TLR cascade NGF signalling via TRKA from the plasma membrane MyD88-independent cascade Mitochondrial biogenesis Toll Like Receptor 2 (TLR2) Cascade Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Myogenesis Toll Like Receptor 3 (TLR3) Cascade ERK/MAPK targets Toll Like Receptor 4 (TLR4) Cascade MAPK targets/ Nuclear events mediated by MAP kinases Transcriptional activation of mitochondrial biogenesis Nuclear Events (kinase and transcription factor activation)
Drugs
Diseases
GWAS			Bone mineral density ( 21533022 23572186 22504420) Bone mineral density (hip) ( 19801982) Height ( 20881960) Mean platelet volume ( 22139419) Platelet counts ( 22139419) Retinal arteriolar caliber ( 23776548) Retinal vascular caliber ( 21060863) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Tonometry ( 17903302)
Protein-Protein Interactions		4 interactors: MEF2C SREBF1 TCF12 TCF4	30 interactors: ASCL1 CCNB1 CDK1 COPS5 CSNK2A1 EP300 EPAS1 GATA4 HDAC4 HDAC5 HDAC7 HDAC9 MAPK14 MAPK7 MEF2D MYOD1 MYOG NCOA2 NOTCH1 PLA2G12A SMAD2 SOX18 SP1 SPTBN1 SUMO1 TEAD1 TWIST2 VGLL2 VGLL4 YWHAZ
Entrez ID		117581	4208
HPRD ID		09616	02809
Ensembl ID		ENSG00000233608	ENSG00000081189
Uniprot IDs		Q8WVJ9	D6R9J8 D8L7E9 Q06413
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Triglyceride Biosynthetic Process Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Regulation Of Triglyceride Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Neurogenesis Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cell Development Positive Regulation Of Lipid Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Muscle Structure Development Positive Regulation Of Protein Binding Regulation Of Neuron Differentiation Regulation Of Skeletal Muscle Tissue Development Regulation Of Secretion Transcription, DNA-templated Regulation Of Neurogenesis Tube Development Regulation Of Organ Growth RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Binding Regulation Of Cell Development Positive Regulation Of Cell Differentiation Response To Glucose Transcription From RNA Polymerase II Promoter Regulation Of Striated Muscle Tissue Development Regulation Of Lipid Biosynthetic Process Cellular Response To Starvation Regulation Of Protein Binding Organ Development Regulation Of Heart Contraction Catenin Import Into Nucleus Primary Heart Field Specification Sinoatrial Valve Morphogenesis Regulation Of Synaptic Activity Cellular Response To Trichostatin A Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Cellular Localization Cellular Response To Nutrient Levels Response To Starvation RNA Metabolic Process Response To Carbohydrate Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Insulin Secretion	Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Striated Muscle Tissue Development Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Regulation Of Nucleic Acid-templated Transcription Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Gene Expression Regulation Of Myotube Differentiation Nucleobase-containing Compound Metabolic Process Cellular Macromolecule Biosynthetic Process RNA Metabolic Process Macromolecule Biosynthetic Process Regulation Of Skeletal Muscle Fiber Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Heart Development Nitrogen Compound Metabolic Process Cardiovascular System Development Positive Regulation Of Metabolic Process Regulation Of Striated Muscle Cell Differentiation Biosynthetic Process Organ Development System Development Striated Muscle Tissue Development Developmental Process Anatomical Structure Development Muscle Tissue Development Cell Differentiation Regulation Of Muscle Cell Differentiation Cellular Metabolic Process Muscle Structure Development Transcription From RNA Polymerase II Promoter Multicellular Organismal Development Regulation Of Metabolic Process Response To Organic Substance Cellular Response To Organic Substance Regulation Of Cell Differentiation Positive Regulation Of Striated Muscle Tissue Development Regulation Of Skeletal Muscle Tissue Development
Tagcloud ?		aberrant acquire assessing biomarker cdk4 cervical contributions coupling defense emt federation gynecology initially invasion invasivity isoform mesenchymal metastasis motility obstetrics oncogenic overriding prognosis regulating senescence similarities undergo	abolishes abrogates adapters assist autoregulatory bhlh carboxy cbp coactivate coactivation coactivators converting diminishes drastically fyd helix mads multimers myocyte myod myogenesis myogenic physically potentiated reinforcing searching terminals transactivation
Tagcloud (Difference) ?		aberrant acquire assessing biomarker cdk4 cervical contributions coupling defense emt federation gynecology initially invasion invasivity isoform mesenchymal metastasis motility obstetrics oncogenic overriding prognosis regulating senescence similarities undergo	abolishes abrogates adapters assist autoregulatory bhlh carboxy cbp coactivate coactivation coactivators converting diminishes drastically fyd helix mads multimers myocyte myod myogenesis myogenic physically potentiated reinforcing searching terminals transactivation
Tagcloud (Intersection) ?