TWIST2 and SREBF1

Number of citations of the paper that reports this interaction (PMID 14654692)
20

Data Source:
HPRD (two hybrid, in vitro)

		TWIST2	SREBF1
Gene Name		twist family bHLH transcription factor 2	sterol regulatory element binding transcription factor 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Transcription Factor Complex Cytoplasm	Golgi Membrane Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol ER To Golgi Transport Vesicle Membrane Integral Component Of Membrane Protein Complex
	Molecular Function	RNA Polymerase II Transcription Factor Binding Transcription Factor Activity DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein Domain Specific Binding Protein Dimerization Activity	DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein Kinase Binding Protein Complex Binding Sterol Response Element Binding Sequence-specific DNA Binding Protein Dimerization Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Osteoblast Differentiation Transcription From RNA Polymerase II Promoter Negative Regulation Of Cell Proliferation Positive Regulation Of Keratinocyte Proliferation Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Apoptotic Process Negative Regulation Of DNA Binding Negative Regulation Of Myeloid Cell Differentiation Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Transcription, DNA-templated Embryonic Cranial Skeleton Morphogenesis Face Morphogenesis Cornea Development In Camera-type Eye	Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Heart Rate By Chemical Signal Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Lipid Metabolic Process Aging Circadian Rhythm Cholesterol Metabolic Process Insulin Receptor Signaling Pathway Lipid Biosynthetic Process Cellular Response To Starvation Response To Glucose Positive Regulation Of Triglyceride Biosynthetic Process Regulation Of Fatty Acid Metabolic Process Lung Development Positive Regulation Of Histone Deacetylation Response To Food Response To Retinoic Acid Response To Progesterone Response To Glucagon Response To Drug Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Insulin Secretion Response To CAMP Cellular Response To Fatty Acid
Pathways			RORA activates circadian gene expression
Drugs
Diseases
GWAS			Parkinson's disease ( 21738487)
Protein-Protein Interactions		4 interactors: MEF2C SREBF1 TCF12 TCF4	35 interactors: AR ATXN1 ATXN1L CDK8 CREBBP ESR1 ESR2 GSK3B HNF4A ID3 KLF13 LMNA MAPK1 MAPK3 MED1 MED12 MED13 MED14 MED17 MED23 MED24 MED25 MED26 MED6 MED7 NR0B1 SIRT1 SMARCD3 SP1 SREBF2 SUMO1 TWIST2 UBE2I YY1 ZBTB7C
Entrez ID		117581	6720
HPRD ID		09616	01701
Ensembl ID		ENSG00000233608	ENSG00000072310
Uniprot IDs		Q8WVJ9	B4DEU6 P36956
PDB IDs			1AM9
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Triglyceride Biosynthetic Process Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Regulation Of Triglyceride Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Neurogenesis Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cell Development Positive Regulation Of Lipid Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Muscle Structure Development Positive Regulation Of Protein Binding Regulation Of Neuron Differentiation Regulation Of Skeletal Muscle Tissue Development Regulation Of Secretion Transcription, DNA-templated Regulation Of Neurogenesis Tube Development Regulation Of Organ Growth RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Binding Regulation Of Cell Development Positive Regulation Of Cell Differentiation Response To Glucose Transcription From RNA Polymerase II Promoter Regulation Of Striated Muscle Tissue Development Regulation Of Lipid Biosynthetic Process Cellular Response To Starvation Regulation Of Protein Binding Organ Development Regulation Of Heart Contraction Catenin Import Into Nucleus Primary Heart Field Specification Sinoatrial Valve Morphogenesis Regulation Of Synaptic Activity Cellular Response To Trichostatin A Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Cellular Localization Cellular Response To Nutrient Levels Response To Starvation RNA Metabolic Process Response To Carbohydrate Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Insulin Secretion	Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Transcription From RNA Polymerase II Promoter Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process RNA Metabolic Process Positive Regulation Of Gene Expression Gene Expression Positive Regulation Of Transcription, DNA-templated Nucleobase-containing Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Metabolic Process Intracellular Receptor Signaling Pathway Androgen Receptor Signaling Pathway Cellular Metabolic Process Negative Regulation Of Cell Differentiation Negative Regulation Of Biosynthetic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Transcription From RNA Polymerase II Promoter Anatomical Structure Development Regulation Of Cellular Process Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Developmental Process Regulation Of Cellular Response To Heat Regulation Of Cell Differentiation Organ Development Cell Differentiation Metabolic Process
Tagcloud ?		aberrant acquire assessing biomarker cdk4 cervical contributions coupling defense emt federation gynecology initially invasion invasivity isoform mesenchymal metastasis motility obstetrics oncogenic overriding prognosis regulating senescence similarities undergo	aberrations acly biphasic cascade chemoprevention citrate desaturase disturbed fads2 fatty harboring hbv hcc hepatocytes lipid livers lyase metabolism mtor pre remarkably s2 starting sterol subsided synchronized transgenic tumorigenesis upregulate
Tagcloud (Difference) ?		aberrant acquire assessing biomarker cdk4 cervical contributions coupling defense emt federation gynecology initially invasion invasivity isoform mesenchymal metastasis motility obstetrics oncogenic overriding prognosis regulating senescence similarities undergo	aberrations acly biphasic cascade chemoprevention citrate desaturase disturbed fads2 fatty harboring hbv hcc hepatocytes lipid livers lyase metabolism mtor pre remarkably s2 starting sterol subsided synchronized transgenic tumorigenesis upregulate
Tagcloud (Intersection) ?