TWIST2 and SREBF1

Number of citations of the paper that reports this interaction (PubMedID 14654692)
41

Data Source:
HPRD (in vitro, two hybrid)

		TWIST2	SREBF1
Description		twist family bHLH transcription factor 2	sterol regulatory element binding transcription factor 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm	Golgi Membrane Chromatin Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol ER To Golgi Transport Vesicle Membrane Membrane Cytoplasmic Vesicle Protein-containing Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Protein Dimerization Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coregulator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Protein Kinase Binding Sterol Response Element Binding Sequence-specific DNA Binding Protein-containing Complex Binding Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Cell Differentiation Positive Regulation Of Cell Migration Developmental Process Negative Regulation Of Osteoblast Differentiation Negative Regulation Of DNA-templated Transcription	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Heart Rate By Chemical Signal Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Lipid Metabolic Process Cholesterol Biosynthetic Process Response To Nutrient Circadian Rhythm Steroid Metabolic Process Cholesterol Metabolic Process Insulin Receptor Signaling Pathway Lipid Biosynthetic Process Cellular Response To Starvation Response To Xenobiotic Stimulus Response To Glucose Response To Fructose Positive Regulation Of Triglyceride Biosynthetic Process Regulation Of Fatty Acid Metabolic Process Insulin Secretion Lung Development Intracellular Receptor Signaling Pathway Regulation Of Protein Stability Response To Food Response To Retinoic Acid Response To Progesterone Cellular Response To Insulin Stimulus SREBP Signaling Pathway Response To Glucagon Response To Lipid MRNA Transcription By RNA Polymerase II Response To Peptide Hormone Fat Cell Differentiation Response To Ethanol Positive Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Insulin Secretion Regulation Of Insulin Secretion Response To CAMP Response To Fatty Acid Cellular Response To Fatty Acid Negative Regulation Of Triglyceride Metabolic Process Regulation Of Mitophagy Positive Regulation Of MiRNA Transcription Regulation Of Protein Targeting To Mitochondrion
Pathways		Transcriptional regulation by RUNX2 Negative Regulation of CDH1 Gene Transcription	Cholesterol biosynthesis FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression
Drugs			Doconexent Omega-3-acid ethyl esters Omega-3 fatty acids Fish oil
Diseases
GWAS		Blond vs. brown/black hair color ( 30531825) Chronic obstructive pulmonary disease ( 30804561) Male-pattern baldness ( 27182965 28196072 29146897) Morning person ( 30696823) Pancreas volume ( 34128465) Rosacea symptom severity ( 29771307) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Youthful appearance (self-reported) ( 32339537)	Coffee consumption ( 31046077) Eosinophil count ( 32888494) Hip index ( 34021172) Lymphocyte count ( 32888494) Parkinson's disease ( 21738487) Resting heart rate ( 27798624) Schizophrenia ( 25056061 28991256 29483656) TB-LM or TBLH-BMD (pleiotropy) ( 28743860) Type 2 diabetes or prostate cancer (pleiotropy) ( 33290408) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 32888494)
Interacting Genes		7 interacting genes: CRK FERD3L GLIS2 MEF2C PLCG2 SREBF1 TCF4	42 interacting genes: AR ATXN1 ATXN1L CDK8 CREBBP DDX39B EP300 ESR1 ESR2 GSK3B HNF4A ID2 ID3 KLF13 LMNA MAPK1 MAPK3 MECOM MED1 MED12 MED13 MED14 MED17 MED23 MED24 MED25 MED26 MED6 MED7 MTNR1B NR0B1 NR5A2 PLK1 PRMT5 SMARCC1 SMARCD3 SP1 SUMO1 TWIST2 UBE2I YY1 ZBTB7C
Entrez ID		117581	6720
HPRD ID		09616	01701
Ensembl ID		ENSG00000233608	ENSG00000072310
Uniprot IDs		Q8WVJ9	B3KR77 P36956
PDB IDs			1AM9
Enriched GO Terms of Interacting Partners?		Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding Cellular Developmental Process RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Response To Yeast DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Neuron Differentiation Regulation Of Transcription By RNA Polymerase II Cell Differentiation Involved In Kidney Development Protein Tyrosine Kinase Binding Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Phosphotyrosine Residue Binding Regulation Of Primary Metabolic Process Developmental Process B Cell Receptor Signaling Pathway Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Smooth Muscle Cell Migration Regulation Of RNA Metabolic Process Response To Fungus Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Macromolecule Metabolic Process Scaffold Protein Binding Response To Transforming Growth Factor Beta Cellular Response To Hormone Stimulus Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Cellular Response To Calcium Ion Sinoatrial Valve Morphogenesis DNA Binding Chromatin Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of MAPK Cascade Regulation Of Metabolic Process Positive Regulation Of Neuron Differentiation Cellular Response To Lipid Helper T Cell Diapedesis Protein Phosphorylated Amino Acid Binding Response To Cholecystokinin Muscle Cell Fate Determination Cell Differentiation Nephron Tubule Epithelial Cell Differentiation Cellular Response To Trichostatin A Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cerebellar Neuron Development Positive Regulation Of Macrophage Apoptotic Process	Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Mediator Complex Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Nucleoplasm Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Core Mediator Complex Positive Regulation Of Transcription Initiation By RNA Polymerase II Nucleus Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Initiation By RNA Polymerase II RNA Polymerase II Preinitiation Complex Assembly Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Initiation Transcription Coregulator Activity Transcription Preinitiation Complex Assembly Transcription Coactivator Activity Positive Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of DNA-templated Transcription, Elongation Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nuclear Vitamin D Receptor Binding Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Elongation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein-DNA Complex Assembly Transcription Coactivator Binding Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Chromatin Binding Negative Regulation Of Macromolecule Biosynthetic Process Somatic Stem Cell Population Maintenance Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Rhythmic Process
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