AGAP1 and UGT1A1

		AGAP1	UGT1A1
Description		ArfGAP with GTPase domain, ankyrin repeat and PH domain 1	UDP glucuronosyltransferase family 1 member A1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Postsynaptic Endosome	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Endoplasmic Reticulum Chaperone Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Nucleotide Binding GTPase Activity GTPase Activator Activity Protein Binding GTP Binding Phospholipid Binding Zinc Ion Binding Metal Ion Binding	Retinoic Acid Binding Enzyme Inhibitor Activity Steroid Binding Protein Binding UDP-glycosyltransferase Activity Glucuronosyltransferase Activity Transferase Activity Glycosyltransferase Activity Enzyme Binding Protein Homodimerization Activity Protein Heterodimerization Activity
	Biological Process	Protein Transport Regulation Of Modification Of Postsynaptic Structure	Lipid Metabolic Process Bilirubin Conjugation Xenobiotic Metabolic Process Steroid Metabolic Process Estrogen Metabolic Process Flavonoid Metabolic Process Retinoic Acid Metabolic Process Negative Regulation Of Fatty Acid Metabolic Process Negative Regulation Of Steroid Metabolic Process Flavone Metabolic Process
Pathways			Glucuronidation Heme degradation Defective UGT1A1 causes hyperbilirubinemia Aspirin ADME Paracetamol ADME
Drugs			Fostamatinib
Diseases			Hyperbilirubinemia; Crigler-Najjar syndrome, type I (CN1); Crigler-Najjar syndrome, type II (CN2); Gilbert Syndrome; Dubin-Johnson syndrome (DJS)
GWAS		Adult body size ( 32376654) Anterior thalamic nuclei volume ( 34006833) Aspartate aminotransferase levels in non-alcoholic fatty liver disease ( 31311600) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Craniofacial microsomia ( 26853712) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular volume ( 29403010) Menarche (age at onset) ( 23667675) Venlafaxine response in generalised anxiety disorder (responders vs non-responders after 24 weeks) ( 28437668)	Bilirubin levels ( 19419973 20639394 22085899 31801373 23371916 19414484) Bilirubin levels in extreme obesity ( 25246029) Cholelithiasis-related traits in sickle cell anemia ( 22558097) Cholesterol, total ( 24097068) Circulating cell-free DNA ( 22511988) Hair greying ( 26926045) LDL cholesterol ( 24097068) LDL cholesterol levels ( 28334899) Low density lipoprotein cholesterol levels ( 32154731) Serum bilirubin levels in metabolic syndrome ( 30621171) Serum metabolite levels ( 23093944) Total bilirubin levels ( 29403010 34117260) Total bilirubin levels in HIV-1 infection ( 25884002)
Interacting Genes		16 interacting genes: APP ARF1 ARF6 CDC42 DYRK1A GRB7 GUCY1A1 GUCY1B1 RAC1 RHOA RSPH14 SMN1 SRC TK1 WEE2-AS1 ZNF534	3 interacting genes: COPZ1 SEC23B UGDH
Entrez ID		116987	54658
HPRD ID		16359	08933
Ensembl ID		ENSG00000157985	ENSG00000241635
Uniprot IDs		B2RZG9 E7EUN2 Q9UPQ3	P22309 Q5DT03
PDB IDs		7EB6
Enriched GO Terms of Interacting Partners?		Regulation Of Supramolecular Fiber Organization GTP Binding Membrane Invagination Thioesterase Binding Focal Adhesion Positive Regulation Of Supramolecular Fiber Organization Regulation Of Endocytosis G Protein Activity Regulation Of Cell-substrate Junction Organization Guanylate Cyclase Complex, Soluble Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Establishment Of Epithelial Cell Polarity Positive Regulation Of Locomotion Postsynapse Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Lamellipodium Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Protein-containing Complex Assembly Regulation Of Cell Projection Organization Regulation Of Cell Junction Assembly Neuron Projection Organization Regulation Of Receptor-mediated Endocytosis Cell Junction Organization Regulation Of Actin Filament Organization Positive Regulation Of Cytokinesis Negative Regulation Of Cellular Component Organization Substrate Adhesion-dependent Cell Spreading Nucleotide Binding G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Regulation Of Synapse Organization Non-canonical Wnt Signaling Pathway Regulation Of Lamellipodium Organization Signaling Receptor Activator Activity Positive Regulation Of Stress Fiber Assembly Guanylate Cyclase Activity Regulation Of Cytoskeleton Organization GTPase Activity Establishment Or Maintenance Of Cell Polarity Circulatory System Process Nitric Oxide-cGMP-mediated Signaling Regulation Of Vesicle-mediated Transport Regulation Of Actin Cytoskeleton Organization Glutamatergic Synapse Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Podosome Assembly Flavonoid Metabolic Process Actin Cytoskeleton Organization Positive Regulation Of Cytoskeleton Organization Regulation Of Focal Adhesion Assembly	UDP-glucuronate Biosynthetic Process UDP-glucose 6-dehydrogenase Activity UDP-glucuronate Metabolic Process COPII-coated Vesicle Budding Protein Transport GTPase Activator Activity Establishment Of Protein Localization Golgi Vesicle Transport Postsynaptic Endosome Heparan Sulfate Proteoglycan Biosynthetic Process Gastrulation With Mouth Forming Second Protein Hexamerization Chondroitin Sulfate Proteoglycan Biosynthetic Process Glycosaminoglycan Biosynthetic Process Intracellular Protein Localization COPII Vesicle Coat COPII-coated Vesicle Cargo Loading COPI-coated Vesicle Membrane COPI Vesicle Coat Regulation Of Modification Of Synaptic Structure Regulation Of Modification Of Postsynaptic Structure Chondroitin Sulfate Proteoglycan Metabolic Process Intracellular Protein Transport Nucleotide-sugar Biosynthetic Process Heparan Sulfate Proteoglycan Metabolic Process Vesicle Cargo Loading Endoplasmic Reticulum Exit Site Membrane Coat NAD Binding Vesicle Budding From Membrane Intra-Golgi Vesicle-mediated Transport Nucleotide-sugar Metabolic Process Glycosaminoglycan Metabolic Process Gastrulation Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Proteoglycan Biosynthetic Process Cytoplasmic Vesicle ER To Golgi Transport Vesicle Membrane
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