AGAP1 and GUCY1B3

Number of citations of the paper that reports this interaction (PMID 15381706)
7

Data Source:
HPRD (in vivo, two hybrid)

		AGAP1	GUCY1B3
Gene Name		ArfGAP with GTPase domain, ankyrin repeat and PH domain 1	guanylate cyclase 1, soluble, beta 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm	Cytoplasm Guanylate Cyclase Complex, Soluble Intracellular Membrane-bounded Organelle
	Molecular Function	GTP Binding Phospholipid Binding ARF GTPase Activator Activity Zinc Ion Binding	Guanylate Cyclase Activity Receptor Activity GTP Binding Heme Binding Metal Ion Binding Protein Heterodimerization Activity Hsp90 Protein Binding
	Biological Process	Small GTPase Mediated Signal Transduction Protein Transport Regulation Of ARF GTPase Activity Positive Regulation Of GTPase Activity	CGMP Biosynthetic Process Nitric Oxide Mediated Signal Transduction Blood Coagulation Blood Circulation
Pathways			Platelet homeostasis Nitric oxide stimulates guanylate cyclase
Drugs
Diseases
GWAS		Menarche (age at onset) ( 23667675)	Blood pressure ( 21909110) Diastolic blood pressure ( 21909115) Systolic blood pressure ( 21909115)
Protein-Protein Interactions		6 interactors: APP GRB7 GUCY1A3 GUCY1B3 SMN1 TK1	4 interactors: AGAP1 APP GUCY1A2 HSP90AA1
Entrez ID		116987	2983
HPRD ID		16359	00769
Ensembl ID		ENSG00000157985	ENSG00000061918
Uniprot IDs		B2RZG9 Q9UPQ3	D6RC99 E9PCN2 Q02153
PDB IDs			2WZ1 3UVJ
Enriched GO Terms of Interacting Partners?		Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Nitric Oxide Mediated Signal Transduction CGMP Biosynthetic Process Response To Wounding CGMP Metabolic Process Cyclic Purine Nucleotide Metabolic Process Nucleotide Biosynthetic Process Cyclic Nucleotide Biosynthetic Process Cyclic Nucleotide Metabolic Process Nucleotide Metabolic Process Fetal Process Involved In Parturition Nucleobase-containing Small Molecule Metabolic Process Response To Defense-related Host Nitric Oxide Production Skeletal Muscle Cell Proliferation Synaptic Growth At Neuromuscular Junction Second-messenger-mediated Signaling Cellular Component Assembly Collateral Sprouting In Absence Of Injury Purine Nucleotide Biosynthetic Process Ribose Phosphate Biosynthetic Process Ribonucleoprotein Complex Assembly Collateral Sprouting Axon Midline Choice Point Recognition Small Molecule Metabolic Process Nucleobase-containing Compound Metabolic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Response To Cortisol Thymidine Metabolic Process Organophosphate Metabolic Process Response To Host Immune Response Axon Choice Point Recognition Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Deoxyribonucleoside Monophosphate Biosynthetic Process Regulation Of Translation Relaxation Of Vascular Smooth Muscle Cellular Nitrogen Compound Metabolic Process Ribonucleotide Metabolic Process Neuron Remodeling Relaxation Of Smooth Muscle Pyrimidine Nucleoside Salvage Pyrimidine-containing Compound Salvage Purine Nucleotide Metabolic Process Blood Circulation Ribose Phosphate Metabolic Process Phosphate-containing Compound Metabolic Process Ribonucleoprotein Complex Biogenesis	Synaptic Growth At Neuromuscular Junction Positive Regulation Of Metabolic Process Collateral Sprouting In Absence Of Injury Protein Import Into Mitochondrial Outer Membrane Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Positive Regulation Of Cellular Biosynthetic Process Neuron Remodeling Axon Guidance Blood Coagulation Hemostasis Chaperone-mediated Protein Complex Assembly Signal Transduction Axonogenesis Positive Regulation Of CGMP Biosynthetic Process Cellular Copper Ion Homeostasis Positive Regulation Of CGMP Metabolic Process Signaling CGMP Biosynthetic Process Protein Refolding Axon Development Regulation Of Body Fluid Levels Cell Communication Cell Morphogenesis Involved In Neuron Differentiation Small Molecule Metabolic Process Wound Healing Chemotaxis Regulation Of CGMP Biosynthetic Process Copper Ion Homeostasis Suckling Behavior Regulation Of Catalytic Activity Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Neuron Projection Morphogenesis Endocytosis Nitric Oxide Metabolic Process Positive Regulation Of Cellular Metabolic Process CGMP Metabolic Process Neuron Maturation MRNA Polyadenylation Regulation Of Cellular Response To Heat Regulation Of Epidermal Growth Factor-activated Receptor Activity Response To Wounding Reactive Nitrogen Species Metabolic Process Regulation Of CGMP Metabolic Process Cell Morphogenesis Involved In Differentiation Mating Behavior Endoplasmic Reticulum Calcium Ion Homeostasis Cellular Response To Stimulus
Tagcloud ?			2j 6j buffer bxd coexpression congruent crosses dba distal extraordinary fluctuation gaba gabra1 gabra2 gabrb2 gabrb3 gabrg2 heritable massive naaa neurotransmission nos1 platforms remarkably subunits unlinked utrs zkscan1
Tagcloud (Difference) ?			2j 6j buffer bxd coexpression congruent crosses dba distal extraordinary fluctuation gaba gabra1 gabra2 gabrb2 gabrb3 gabrg2 heritable massive naaa neurotransmission nos1 platforms remarkably subunits unlinked utrs zkscan1
Tagcloud (Intersection) ?