AGAP1 and GUCY1A3

Number of citations of the paper that reports this interaction (PMID 15381706)
7

Data Source:
HPRD (in vivo, two hybrid)

		AGAP1	GUCY1A3
Gene Name		ArfGAP with GTPase domain, ankyrin repeat and PH domain 1	guanylate cyclase 1, soluble, alpha 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm	Guanylate Cyclase Complex, Soluble
	Molecular Function	GTP Binding Phospholipid Binding ARF GTPase Activator Activity Zinc Ion Binding	Guanylate Cyclase Activity Receptor Activity GTP Binding Heme Binding
	Biological Process	Small GTPase Mediated Signal Transduction Protein Transport Regulation Of ARF GTPase Activity Positive Regulation Of GTPase Activity	CGMP Biosynthetic Process Nitric Oxide Mediated Signal Transduction Blood Coagulation Blood Circulation Regulation Of Blood Pressure Positive Regulation Of CGMP Biosynthetic Process Response To Defense-related Host Nitric Oxide Production Relaxation Of Vascular Smooth Muscle
Pathways			Platelet homeostasis Nitric oxide stimulates guanylate cyclase
Drugs
Diseases
GWAS		Menarche (age at onset) ( 23667675)	Blood pressure ( 21909110) Coronary heart disease ( 22751097) Diastolic blood pressure ( 21909115) Systolic blood pressure ( 21909115)
Protein-Protein Interactions		6 interactors: APP GRB7 GUCY1A3 GUCY1B3 SMN1 TK1	4 interactors: AGAP1 IKBKG MAPK8 STUB1
Entrez ID		116987	2982
HPRD ID		16359	00768
Ensembl ID		ENSG00000157985	ENSG00000164116
Uniprot IDs		B2RZG9 Q9UPQ3	B3KU69 Q02108
PDB IDs			3UVJ
Enriched GO Terms of Interacting Partners?		Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Nitric Oxide Mediated Signal Transduction CGMP Biosynthetic Process Response To Wounding CGMP Metabolic Process Cyclic Purine Nucleotide Metabolic Process Nucleotide Biosynthetic Process Cyclic Nucleotide Biosynthetic Process Cyclic Nucleotide Metabolic Process Nucleotide Metabolic Process Fetal Process Involved In Parturition Nucleobase-containing Small Molecule Metabolic Process Response To Defense-related Host Nitric Oxide Production Skeletal Muscle Cell Proliferation Synaptic Growth At Neuromuscular Junction Second-messenger-mediated Signaling Cellular Component Assembly Collateral Sprouting In Absence Of Injury Purine Nucleotide Biosynthetic Process Ribose Phosphate Biosynthetic Process Ribonucleoprotein Complex Assembly Collateral Sprouting Axon Midline Choice Point Recognition Small Molecule Metabolic Process Nucleobase-containing Compound Metabolic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Response To Cortisol Thymidine Metabolic Process Organophosphate Metabolic Process Response To Host Immune Response Axon Choice Point Recognition Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Deoxyribonucleoside Monophosphate Biosynthetic Process Regulation Of Translation Relaxation Of Vascular Smooth Muscle Cellular Nitrogen Compound Metabolic Process Ribonucleotide Metabolic Process Neuron Remodeling Relaxation Of Smooth Muscle Pyrimidine Nucleoside Salvage Pyrimidine-containing Compound Salvage Purine Nucleotide Metabolic Process Blood Circulation Ribose Phosphate Metabolic Process Phosphate-containing Compound Metabolic Process Ribonucleoprotein Complex Biogenesis	Positive Regulation Of Catalytic Activity Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Negative Regulation Of Protein Binding Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway JNK Cascade Negative Regulation Of Binding Regulation Of Catalytic Activity Toll-like Receptor Signaling Pathway Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of Signal Transduction Activation Of Innate Immune Response Regulation Of Protein Binding Regulation Of Signaling Positive Regulation Of Chaperone-mediated Protein Complex Assembly Positive Regulation Of Innate Immune Response Positive Regulation Of Metabolic Process MAPK Cascade Fc-epsilon Receptor Signaling Pathway Regulation Of Innate Immune Response Regulation Of Binding Fc Receptor Signaling Pathway JUN Phosphorylation Signal Transduction By Phosphorylation Positive Regulation Of Deacetylase Activity Cellular Response To Stress Ubiquitin-dependent SMAD Protein Catabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Determination Of Dorsal Identity Immune Response-regulating Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction Regulation Of Glucocorticoid Metabolic Process Cellular Response To Nitric Oxide Regulation Of Cellular Protein Metabolic Process Immune Response-regulating Signaling Pathway Misfolded Or Incompletely Synthesized Protein Catabolic Process Cellular Response To Misfolded Protein Signal Transduction Response To Nitric Oxide
Tagcloud ?			2j 6j buffer bxd coexpression congruent crosses dba distal extraordinary fluctuation gaba gabra1 gabra2 gabrb2 gabrb3 gabrg2 heritable massive naaa neurotransmission nos1 platforms remarkably subunits unlinked utrs zkscan1
Tagcloud (Difference) ?			2j 6j buffer bxd coexpression congruent crosses dba distal extraordinary fluctuation gaba gabra1 gabra2 gabrb2 gabrb3 gabrg2 heritable massive naaa neurotransmission nos1 platforms remarkably subunits unlinked utrs zkscan1
Tagcloud (Intersection) ?