ARL11 and PLD1

Number of citations of the paper that reports this interaction (PubMedID 35844135)
78

Data Source:
BioGRID (enzymatic study)

		ARL11	PLD1
Description		ARF like GTPase 11	phospholipase D1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane	Golgi Membrane Cytoplasm Lysosomal Membrane Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Endomembrane System Membrane Apical Plasma Membrane Endocytic Vesicle Cytoplasmic Vesicle Late Endosome Membrane Organelle Subcompartment Specific Granule Membrane Perinuclear Region Of Cytoplasm Tertiary Granule Membrane Cholinergic Synapse
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding	Catalytic Activity Phospholipase D Activity Protein Binding Hydrolase Activity Phosphatidylinositol Binding
	Biological Process	Hematopoietic Progenitor Cell Differentiation Intracellular Protein Transport Vesicle-mediated Transport	Lipid Metabolic Process Phosphatidic Acid Biosynthetic Process Chemotaxis Small GTPase-mediated Signal Transduction Ras Protein Signal Transduction Phospholipid Catabolic Process Lipid Catabolic Process Cellular Response To Nutrient Regulation Of Microvillus Assembly Intracellular Signal Transduction Positive Regulation Of Translation Regulation Of Vesicle-mediated Transport Regulation Of Synaptic Vesicle Cycle
Pathways			Synthesis of PG Synthesis of PA Role of phospholipids in phagocytosis Neutrophil degranulation RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RHOG GTPase cycle
Drugs			Choline LAX-101 Choline salicylate
Diseases
GWAS		Multiple sclerosis ( 23412934) Refractive error ( 32231278) Systemic lupus erythematosus ( 33536424)	Cerebrospinal fluid AB1-42 levels ( 29274321) Eosinophil count ( 32888494) Red cell distribution width ( 27863252 28957414 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		4 interacting genes: JAK2 PLD1 SMARCB1 TRIP13	28 interacting genes: ACTA1 ACTB ACTG1 ARF1 ARF6 ARIH1 ARL11 ARL14 BIN1 CAV1 CDC42 EGFR EGLN1 HIF1A PEA15 PIP5K1A PKN1 PKN3 PRKCA RAC1 RALA RHEB RHOA RHOG SNCA SRC STXBP1 VHL
Entrez ID		115761	5337
HPRD ID		12484	03855
Ensembl ID		ENSG00000152213	ENSG00000075651
Uniprot IDs		Q969Q4	Q13393 Q59EA4
PDB IDs			6U8Z
Enriched GO Terms of Interacting Partners?		Histone H3Y41 Kinase Activity Nuclear Receptor-mediated Mineralocorticoid Signaling Pathway Symbiont-induced Defense-related Programmed Cell Death Interleukin-35-mediated Signaling Pathway Regulation Of Sister Chromatid Segregation Regulation Of Mitotic Metaphase/anaphase Transition Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Regulation Of Postsynapse To Nucleus Signaling Pathway Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation Organelle Subcompartment Regulation Of Chromosome Segregation Nucleobase-containing Compound Biosynthetic Process Interleukin-12 Receptor Complex Positive Regulation Of Skeletal Muscle Cell Proliferation Positive Regulation Of Growth Hormone Receptor Signaling Pathway Positive Regulation Of Glucose Mediated Signaling Pathway Germ Cell Nucleus Meiotic Recombination Checkpoint Signaling Granulocyte-macrophage Colony-stimulating Factor Signaling Pathway Response To Interleukin-12 Interleukin-23 Receptor Complex Granulocyte Macrophage Colony-stimulating Factor Receptor Complex Activation Of Janus Kinase Activity Regulation Of Glucose Mediated Signaling Pathway Endomembrane System Type 1 Angiotensin Receptor Binding Thrombopoietin-mediated Signaling Pathway Positive Regulation Of Gene Expression Negative Regulation Of Growth Hormone Receptor Signaling Pathway Interleukin-12-mediated Signaling Pathway Positive Regulation Of NK T Cell Activation RNA Metabolic Process Erythropoietin-mediated Signaling Pathway Interleukin-3-mediated Signaling Pathway Macromolecule Biosynthetic Process Negative Regulation Of 3'-UTR-mediated MRNA Stabilization Post-embryonic Hemopoiesis Positive Regulation Of Lymphocyte Activation Interleukin-23-mediated Signaling Pathway Positive Regulation Of Cell-cell Adhesion Growth Hormone Receptor Binding Cellular Response To Interleukin-3 Interleukin-5-mediated Signaling Pathway Interleukin-12 Receptor Binding Positive Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Nuclear Receptor-mediated Corticosteroid Signaling Pathway Extrinsic Component Of Plasma Membrane Positive Regulation Of NK T Cell Proliferation Transcription By RNA Polymerase II	Focal Adhesion Nucleotide Binding Regulation Of Endocytosis Regulation Of Vesicle-mediated Transport GTPase Activity GTP Binding Regulation Of Cell Junction Assembly Regulation Of Actin Filament-based Process Protein Kinase Binding Cell Junction Organization Regulation Of Actin Cytoskeleton Organization Regulation Of Transport Actin Cytoskeleton Organization Cytosol Positive Regulation Of Cellular Component Biogenesis Establishment Or Maintenance Of Cell Polarity Regulation Of Cytoskeleton Organization Enzyme Binding Positive Regulation Of Cell Migration Actin Filament-based Process Regulation Of Organelle Organization Plasma Membrane Positive Regulation Of Cell Motility Intracellular Signal Transduction Positive Regulation Of Locomotion Regulation Of Synapse Organization Regulation Of Cellular Component Organization Cell Motility Regulation Of Locomotion Intracellular Signaling Cassette Regulation Of Cell Communication Regulation Of Signaling Postsynapse Regulation Of Cell Projection Assembly G Protein Activity Regulation Of Apoptotic Process Vesicle-mediated Transport Regulation Of Supramolecular Fiber Organization Regulation Of Synaptic Vesicle Recycling Regulation Of Developmental Process Cytoplasm Regulation Of Cell-substrate Junction Organization Regulation Of Programmed Cell Death Glutamatergic Synapse Cell Junction Assembly Regulation Of Actin Filament Organization Protein-containing Complex Cellular Localization Actin Filament Regulation Of Protein-containing Complex Assembly
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