KIR3DL3 and C5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KIR3DL3	C5
Description		killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 3	complement C5
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Extracellular Region Membrane Attack Complex Extracellular Space Membrane Other Organism Cell Membrane Extracellular Exosome Transmembrane Transporter Complex
	Molecular Function	Protein Binding	G Protein-coupled Receptor Binding Endopeptidase Inhibitor Activity Signaling Receptor Binding Protein Binding Chemokine Activity Receptor Ligand Activity
	Biological Process	Immune Response-regulating Signaling Pathway Cell Communication	Complement Activation, Lectin Pathway Immune System Process Regulation Of Immune System Process Chemotaxis Inflammatory Response Complement Activation Complement Activation, Alternative Pathway Complement Activation, Classical Pathway Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Macrophage Chemotaxis Cell Migration Leukocyte Chemotaxis Killing Of Cells Of Another Organism Positive Regulation Of Chemokine Production Innate Immune Response Regulation Of Chemotaxis Cell Chemotaxis Complement Activation, GZMK Pathway
Pathways			Terminal pathway of complement Activation of C3 and C5 Peptide ligand-binding receptors G alpha (i) signalling events Regulation of Complement cascade
Drugs			Human immunoglobulin G Eculizumab Zinc Copper Ravulizumab Zinc acetate Zinc chloride Zinc sulfate, unspecified form Zilucoplan Vilobelimab
Diseases			Late complement pathway defects, including the following seven diseases: C5 deficiency; C6 deficiency; C7 deficiency; C8 alpha-chain deficiency; C8 beta-chain deficiency; C8 gamma-chain deficiency; C9 deficiency
GWAS		Monocyte percentage of white cells ( 32888494)	Blood protein levels ( 30072576) Coronary artery disease ( 29212778) Hip circumference adjusted for BMI ( 25673412) Pulse pressure ( 27841878) Refractive error ( 32231278) Rheumatoid arthritis ( 19503088 24390342 30891314)
Interacting Genes		23 interacting genes: ADAM33 AGTRAP ASIC1 C5 CD53 CMTM5 CTXN3 EDDM3B EMP3 GIMAP5 JAGN1 LAPTM5 NINJ2 OLFM4 SERP1 SLC35A1 SLC41A2 SMIM3 SYS1 TAFA2 TNMD UPK2 VAMP5	22 interacting genes: ANKS6 AQP6 C2 C3 C5AR1 C6 C7 C8B CPB2 CPLX4 CPN1 CREB3L1 EBP KEL KIR3DL3 LMNA MMGT1 NEMP1 PGRMC2 POU6F2 SSMEM1 VEZT
Entrez ID		115653	727
HPRD ID		17236	00405
Ensembl ID		ENSG00000242019	ENSG00000106804
Uniprot IDs		A0A8I5QEB2	A0A8Q3SID6 P01031 Q59GS8
PDB IDs			1CFA 1KJS 1XWE 3CU7 3HQA 3HQB 3KLS 3KM9 3PRX 3PVM 4A5W 4E0S 4P39 4UU9 5B4P 5B71 5HCC 5HCD 5HCE 5I5K 6H03 6H04 6RPT 6RQJ 7AD6 7AD7 7NYC 7NYD 7Y64 8B0F 8B0G 8B0H 8HK5 8HQC 8IA2 8JZZ
Enriched GO Terms of Interacting Partners?		Membrane Inorganic Cation Transmembrane Transporter Activity	Complement Activation, GZMK Pathway Complement Activation, Classical Pathway Complement Activation Membrane Attack Complex Other Organism Cell Membrane Transmembrane Transporter Complex Killing Of Cells Of Another Organism Complement Activation, Alternative Pathway Activation Of Immune Response Classical-complement-pathway C3/C5 Convertase Complex Positive Regulation Of Immune Response Cell Killing Regulation Of Immune Response Nuclear Envelope Immune Effector Process Positive Regulation Of Apoptotic Cell Clearance Humoral Immune Response Regulation Of Apoptotic Cell Clearance Complement Activation, Lectin Pathway Activation Of Membrane Attack Complex Complement Receptor Mediated Signaling Pathway Regulation Of Immune System Process Positive Regulation Of Immune System Process Opsonization Symbiont Cell Surface Metallocarboxypeptidase Activity Amyloid-beta Clearance
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?