KIR3DL3 and ASIC1

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		KIR3DL3	ASIC1
Name		killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 3	acid sensing ion channel subunit 1
Structure		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Golgi Apparatus Plasma Membrane Cell Surface Membrane Dendrite Cell Projection Synapse Postsynaptic Membrane Presynapse Postsynaptic Density Membrane Glutamatergic Synapse
	Molecular Function	Protein Binding	Monoatomic Ion Channel Activity Monoatomic Cation Channel Activity Sodium Channel Activity Protein Binding Ligand-gated Sodium Channel Activity Monoatomic Ion-gated Channel Activity Inorganic Cation Transmembrane Transporter Activity PH-gated Monoatomic Ion Channel Activity
	Biological Process	Immune Response-regulating Signaling Pathway Cell Communication	Behavioral Fear Response Response To Amphetamine Monoatomic Ion Transport Monoatomic Cation Transport Sodium Ion Transport Calcium Ion Transport Neurotransmitter Secretion Memory Associative Learning Response To Acidic PH Monoatomic Ion Transmembrane Transport Sodium Ion Transmembrane Transport Regulation Of Membrane Potential Negative Regulation Of Neurotransmitter Secretion Sensory Perception Of Sour Taste Establishment Of Localization In Cell Calcium Ion Transmembrane Transport Cellular Response To PH Inorganic Cation Transmembrane Transport Regulation Of Postsynapse Assembly
Pathways		None	Stimuli-sensing channels
Drugs		None	Amiloride
GWAS		Monocyte percentage of white cells ( 32888494 )	No GWAS studies recorded
Interacting Genes		23 interacting genes: ADAM33 AGTRAP ASIC1 C5 CD53 CMTM5 CTXN3 EDDM3B EMP3 GIMAP5 JAGN1 LAPTM5 NINJ2 OLFM4 SERP1 SLC35A1 SLC41A2 SMIM3 SYS1 TAFA2 TNMD UPK2 VAMP5	7 interacting genes: ASIC2 ATXN3 KIR3DL3 MGST2 PICK1 PRKACA STOM
Entrez ID		115653	41
HPRD ID		17236	04182
Ensembl ID		ENSG00000242019	ENSG00000110881
Uniprot IDs		A0A8I5QEB2	A8K1U5 P78348
PDB IDs		Not available	6L6I 6L6N 7CFS 7CFT 7RNN
GO Terms Enriched among Interactors		Membrane Inorganic Cation Transmembrane Transporter Activity	Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Systemic Arterial Blood Pressure By Aortic Arch Baroreceptor Feedback Plasma Membrane Regulation Of Monoatomic Ion Transport Negative Regulation Of TORC1 Signaling Response To Heat Protein Localization To Cytosolic Proteasome Complex TOR Signaling Cellular Response To Nutrient Levels TORC1 Signaling Cellular Response To Heat Negative Regulation Of TOR Signaling PH-gated Sodium Channel Activity Monoatomic Ion-gated Channel Activity Response To Nutrient Levels Regulation Of TORC1 Signaling Regulation Of Establishment Of Protein Localization Membrane Regulation Of TOR Signaling Response To Temperature Stimulus Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate Protein Localization To Lipid Droplet Membrane Curvature Sensor Activity Cell Communication Positive Regulation Of Endocytosis Sensory Perception Of Sour Taste Regulation Of Blood Circulation Regulation Of Cell Junction Assembly Intracellular Protein Localization Regulation Of Transport Nervous System Process Involved In Regulation Of Systemic Arterial Blood Pressure Ligand-gated Sodium Channel Activity Synapse Perinuclear Region Of Cytoplasm Host-mediated Perturbation Of Viral Genome Replication Identical Protein Binding Host-mediated Activation Of Viral Genome Replication Regulation Of Protein Localization Glutathione Binding Leukotriene-C4 Synthase Activity Cellular Response To Starvation Monoubiquitinated Protein Deubiquitination Nuclear Inclusion Body Response To Starvation Regulation Of Proteasomal Protein Catabolic Process Cellular Response To Misfolded Protein CAMP-dependent Protein Kinase Complex Regulation Of Hormone Secretion Regulation Of Peptide Hormone Secretion Cellular Response To Parathyroid Hormone Stimulus