LENG8 and CPSF7

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LENG8	CPSF7
Description		leukocyte receptor cluster member 8	cleavage and polyadenylation specific factor 7
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Protein-containing Complex	Nucleus Nucleoplasm Cytoplasm MRNA Cleavage And Polyadenylation Specificity Factor Complex MRNA Cleavage Factor Complex Membrane
	Molecular Function	Protein Binding	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding
	Biological Process		MRNA Processing MRNA 3'-end Processing Protein Tetramerization Protein Heterotetramerization MRNA Alternative Polyadenylation Co-transcriptional MRNA 3'-end Processing, Cleavage And Polyadenylation Pathway
Pathways			mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs RHOBTB1 GTPase cycle
Drugs
Diseases
GWAS
Interacting Genes		49 interacting genes: ANKHD1 ARID5A ATN1 BAG3 C10orf55 CAMK2A CEP70 CFAP53 CIMIP2B COG2 CPSF7 CYSRT1 DMRTB1 DVL3 GSE1 HMGXB4 HNRNPM IKBKG INCA1 INTS11 KDM1A LASP1 MAGED1 MAPK1IP1L MIA3 MSX2 MYOZ3 NCBP3 NUTM2F PCID2 PER2 PRDM16 PRMT5 PRMT6 PYGO1 RHOXF2 SMARCB1 SMN1 SMYD1 SNRPA SOCS7 SUV39H1 TFG TLE5 TNIP1 TRAF4 TSG101 VGLL3 ZNF34	106 interacting genes: ALG13 APBB1 ARMC7 ATXN1 BAG4 BCAS2 CATSPER1 CD2BP2 CEBPA CEP55 CFAP206 CLK2 CSNK2A1 CTBP1 CTTN DMRTB1 DRC4 DVL2 EIF4ENIF1 EPM2AIP1 ESS2 EWSR1 EXOSC1 EXOSC5 EXOSC8 GCC1 GRB2 GTSE1 GUCD1 HINT1 HNRNPF ITCH KHDRBS3 KRT31 LENG1 LENG8 LNX1 LSM5 MAGOH MAILR MIR1-1 MIR1-2 MIR10B MIR128-2 MIR141 MIR155 MIR16-1 MIR17 MIR18B MIR199A1 MIR19A MIR19B1 MIR25 MIR29C MIR34B MIR7-1 MIR9-2 MIR93 MIRLET7B MREG NCK2 NIP7 NUDT21 NXF1 OGT PATZ1 PID1 PQBP1 PRKAA2 PRMT2 PRPF6 QKI RBFOX2 RBM10 RBM7 RBPMS RUNX1T1 SEC23B SF1 SF3B4 SFPQ SLAIN1 SMAD3 SNRNP25 SNRPC SNRPF SNW1 SNX18 SORBS3 SPG21 SRPK2 SRSF1 SRSF4 SUMO2 SUPT5H TFIP11 TLE5 TNS2 TUT4 TXNL4A U2AF2 UNKL WBP4 WWOX YTHDF1 YTHDF3
Entrez ID		114823	79869
HPRD ID		11226	16906
Ensembl ID		ENSG00000167615	ENSG00000149532
Uniprot IDs		A0A087WUE4 C9JMY0 Q96PV6	B4DGF8 Q8N684
PDB IDs			3N9U
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleus Histone H3 Methyltransferase Activity Transcription Corepressor Activity Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Histone Arginine N-methyltransferase Activity Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Histone H4R3 Methyltransferase Activity Chromatin Remodeling Protein Binding Negative Regulation Of RNA Metabolic Process Chromatin Organization Methyltransferase Activity Regulation Of Gene Expression Histone Methyltransferase Activity Transcription Coactivator Activity Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Histone H3K9me2 Methyltransferase Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Methylation Protein-arginine N-methyltransferase Activity Histone H3K9 Methyltransferase Activity Regulation Of Metabolic Process Nucleoplasm Circadian Rhythm Negative Regulation Of Macromolecule Biosynthetic Process Transcription Cis-regulatory Region Binding Circadian Regulation Of Gene Expression P53 Binding Epigenetic Regulation Of Gene Expression Regulation Of Signal Transduction Negative Regulation Of Biosynthetic Process Developmental Process DNA-templated Transcription Termination	MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex MRNA Metabolic Process Regulatory NcRNA-mediated Post-transcriptional Gene Silencing RNA Splicing, Via Transesterification Reactions MRNA Processing RNA Splicing Post-transcriptional Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression MRNA Splicing, Via Spliceosome Regulatory NcRNA-mediated Gene Silencing RNA Processing Negative Regulation Of Biosynthetic Process Regulation Of MRNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Spliceosomal Complex Negative Regulation Of Gene Expression RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process RNA Binding Regulation Of Gene Expression Regulation Of RNA Splicing Regulation Of Macromolecule Metabolic Process MRNA 3'-UTR Binding Regulation Of Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Nuclear Speck Regulation Of MRNA Processing Positive Regulation Of MRNA Metabolic Process Nucleic Acid Metabolic Process Positive Regulation Of MRNA Catabolic Process Regulation Of MRNA Stability Nucleic Acid Binding Nucleoplasm MRNA Binding Regulation Of RNA Stability MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Translation Regulation Of Primary Metabolic Process Catalytic Step 2 Spliceosome Regulation Of RNA Metabolic Process Regulation Of Translation Regulation Of Nucleobase-containing Compound Metabolic Process MRNA Destabilization Positive Regulation Of Catabolic Process Regulation Of Cardiac Muscle Hypertrophy RNA Destabilization
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