LENG8 and PYGO1

Number of citations of the paper that reports this interaction (PubMedID 20936779)
36

Data Source:
BioGRID (two hybrid)

		LENG8	PYGO1
Description		leukocyte receptor cluster member 8	pygopus family PHD finger 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Protein-containing Complex	Nucleus Nucleoplasm
	Molecular Function	Protein Binding	Protein Binding Zinc Ion Binding Metal Ion Binding Histone H3K4me3 Reader Activity
	Biological Process		Kidney Development Hematopoietic Progenitor Cell Differentiation Chromatin Organization Spermatid Development Spermatid Nucleus Differentiation Wnt Signaling Pathway Protein Localization To Nucleus Positive Regulation Of Transcription By RNA Polymerase II Canonical Wnt Signaling Pathway
Pathways			Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex
Drugs
Diseases
GWAS			Appendicular lean mass ( 33097823) Brain morphology (MOSTest) ( 32665545)
Interacting Genes		49 interacting genes: ANKHD1 ARID5A ATN1 BAG3 C10orf55 CAMK2A CEP70 CFAP53 CIMIP2B COG2 CPSF7 CYSRT1 DMRTB1 DVL3 GSE1 HMGXB4 HNRNPM IKBKG INCA1 INTS11 KDM1A LASP1 MAGED1 MAPK1IP1L MIA3 MSX2 MYOZ3 NCBP3 NUTM2F PCID2 PER2 PRDM16 PRMT5 PRMT6 PYGO1 RHOXF2 SMARCB1 SMN1 SMYD1 SNRPA SOCS7 SUV39H1 TFG TLE5 TNIP1 TRAF4 TSG101 VGLL3 ZNF34	6 interacting genes: BCL9 CARM1 CTNNB1 LENG8 PRMT6 SPTBN1
Entrez ID		114823	26108
HPRD ID		11226	06064
Ensembl ID		ENSG00000167615	ENSG00000171016
Uniprot IDs		A0A087WUE4 C9JMY0 Q96PV6	Q9Y3Y4
PDB IDs			2VP7 2VPB 2VPD 2VPE 2VPG
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleus Histone H3 Methyltransferase Activity Transcription Corepressor Activity Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Histone Arginine N-methyltransferase Activity Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Histone H4R3 Methyltransferase Activity Chromatin Remodeling Protein Binding Negative Regulation Of RNA Metabolic Process Chromatin Organization Methyltransferase Activity Regulation Of Gene Expression Histone Methyltransferase Activity Transcription Coactivator Activity Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Histone H3K9me2 Methyltransferase Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Methylation Protein-arginine N-methyltransferase Activity Histone H3K9 Methyltransferase Activity Regulation Of Metabolic Process Nucleoplasm Circadian Rhythm Negative Regulation Of Macromolecule Biosynthetic Process Transcription Cis-regulatory Region Binding Circadian Regulation Of Gene Expression P53 Binding Epigenetic Regulation Of Gene Expression Regulation Of Signal Transduction Negative Regulation Of Biosynthetic Process Developmental Process DNA-templated Transcription Termination	Histone H3R2 Methyltransferase Activity Histone Arginine N-methyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Protein-arginine N-methyltransferase Activity Beta-catenin-TCF Complex Histone Methyltransferase Activity Transcription Coactivator Activity Regulation Of Cell Communication Regulation Of Signal Transduction Beta-catenin Binding Regulation Of Signaling Maintenance Of Cell Number Muscle Cell Differentiation Canonical Wnt Signaling Pathway Stem Cell Population Maintenance Myotube Differentiation Involved In Skeletal Muscle Regeneration Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Mesenchymal Stem Cell Differentiation Oviduct Development Positive Regulation Of Determination Of Dorsal Identity Negative Regulation Of Mitotic Cell Cycle, Embryonic Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Beta-catenin-ICAT Complex Negative Regulation Of Epithelial Cell Differentiation Involved In Kidney Development Acinar Cell Differentiation Positive Regulation Of Proteoglycan Biosynthetic Process Regulation Of Timing Of Anagen Fungiform Papilla Formation Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Beta-catenin-TCF7L2 Complex Cellular Response To Indole-3-methanol Mesenchymal Cell Proliferation Involved In Lung Development Glial Cell Fate Determination Astrocyte-dopaminergic Neuron Signaling Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Central Nervous System Vasculogenesis Metanephros Morphogenesis Trachea Morphogenesis Regulation Of Mitotic Cell Cycle, Embryonic Renal Inner Medulla Development Scrib-APC-beta-catenin Complex Cranial Ganglion Development Regulation Of Centriole-centriole Cohesion Renal Outer Medulla Development Renal Vesicle Formation Embryonic Skeletal Limb Joint Morphogenesis Protein-containing Complex Glial Cell-neuron Signaling Lung Induction Regulation Of Centromeric Sister Chromatid Cohesion
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