LENG8 and PYGO1

Number of citations of the paper that reports this interaction (PMID 20936779)
48

Data Source:
BioGRID (two hybrid)

		LENG8	PYGO1
Gene Name		leukocyte receptor cluster (LRC) member 8	pygopus family PHD finger 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component		Nucleoplasm
	Molecular Function	Protein Binding	Protein Binding Zinc Ion Binding
	Biological Process		Kidney Development Hematopoietic Progenitor Cell Differentiation Spermatid Nucleus Differentiation Post-embryonic Development Wnt Signaling Pathway Protein Localization To Nucleus Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways			misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation formation of the beta-catenin:TCF transactivating complex XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer deactivation of the beta-catenin transactivating complex
Drugs
Diseases
GWAS
Protein-Protein Interactions		13 interactors: ATN1 CEP70 DMRTB1 KDM1A MAPK1IP1L PRMT5 PRMT6 PYGO1 RHOXF2 SMN1 SMYD1 SNRPA SUV39H1	6 interactors: BCL9 CARM1 CTNNB1 LENG8 PRMT6 SPTBN1
Entrez ID		114823	26108
HPRD ID		11226	06064
Ensembl ID		ENSG00000167615
Uniprot IDs		E7EQP8 F8W9Q9 Q96PV6	A7Y2D6 Q9Y3Y4
PDB IDs			2VP7 2VPB 2VPD 2VPE 2VPG
Enriched GO Terms of Interacting Partners?		Histone Methylation Histone Modification Protein Methylation RNA Metabolic Process Gene Expression Negative Regulation Of Transcription, DNA-templated Chromatin Modification Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Histone H4-R3 Methylation Chromatin Organization Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Peptidyl-arginine N-methylation Regulation Of RNA Metabolic Process Methylation Transcription, DNA-templated Nucleobase-containing Compound Metabolic Process Histone Arginine Methylation Peptidyl-arginine Methylation RNA Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Chromosome Organization Cellular Nitrogen Compound Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Spliceosomal SnRNP Assembly Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Organelle Organization Negative Regulation Of Transcription From RNA Polymerase II Promoter Ribonucleoprotein Complex Biogenesis Regulation Of Primitive Erythrocyte Differentiation RNA Splicing Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Peptidyl-amino Acid Modification Histone Lysine Methylation Histone H3-R2 Methylation Peptidyl-arginine Methylation, To Symmetrical-dimethyl Arginine MRNA Processing Peptidyl-lysine Methylation Regulation Of Transcription From RNA Polymerase II Promoter NcRNA Metabolic Process	Histone H3-R2 Methylation Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Peptidyl-arginine N-methylation Histone Arginine Methylation Peptidyl-arginine Methylation Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Cartilage Development Canonical Wnt Signaling Pathway Histone H3-R17 Methylation Histone Methylation Stem Cell Maintenance Negative Regulation Of Mitotic Cell Cycle, Embryonic Myotube Differentiation Involved In Skeletal Muscle Regeneration Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Schwann Cell Proliferation Cellular Response To Insulin-like Growth Factor Stimulus Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Protein Methylation Regulation Of Organ Morphogenesis Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Cardiac Outflow Tract Cell Proliferation Renal Inner Medulla Development Renal Outer Medulla Development Mesenchymal Cell Proliferation Involved In Lung Development Glial Cell Fate Determination Oviduct Development Regulation Of Centriole-centriole Cohesion Intracellular Receptor Signaling Pathway Positive Regulation Of Determination Of Dorsal Identity Lung Induction Embryonic Skeletal Limb Joint Morphogenesis Regulation Of Growth Plate Cartilage Chondrocyte Proliferation Canonical Wnt Signaling Pathway Involved In Regulation Of Cell Proliferation Central Nervous System Vasculogenesis Trachea Formation Cellular Response To Indole-3-methanol Stem Cell Development Regulation Of Centromeric Sister Chromatid Cohesion Renal Vesicle Formation Common-partner SMAD Protein Phosphorylation Skeletal System Morphogenesis Wnt Signaling Pathway Negative Regulation Of Protein Sumoylation Positive Regulation Of Branching Involved In Lung Morphogenesis Regulation Of Mitotic Cell Cycle, Embryonic SMAD Protein Import Into Nucleus Stem Cell Differentiation Positive Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Branching Involved In Lung Morphogenesis Regulation Of Secondary Heart Field Cardioblast Proliferation
Tagcloud ?			analyze bioinformatic bioinformatics category chemical coil contained formula heart helix highest homeodomain hydrophilic hydrophobicity hyrdrophilicity isoelectric physical plant point progress proline random regulate residues secondary structure theoretical tools transmembrane
Tagcloud (Difference) ?			analyze bioinformatic bioinformatics category chemical coil contained formula heart helix highest homeodomain hydrophilic hydrophobicity hyrdrophilicity isoelectric physical plant point progress proline random regulate residues secondary structure theoretical tools transmembrane
Tagcloud (Intersection) ?