MAL2 and GAD2

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		MAL2	GAD2
Gene Name		mal, T-cell differentiation protein 2 (gene/pseudogene)	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endomembrane System Integral Component Of Membrane Apical Plasma Membrane Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Golgi Membrane Cytosol Plasma Membrane Cell Junction Axon Synaptic Vesicle Membrane Anchored Component Of Membrane Presynaptic Membrane Perinuclear Region Of Cytoplasm Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane
	Molecular Function	Protein Binding	Glutamate Decarboxylase Activity Protein Binding Glutamate Binding Pyridoxal Phosphate Binding Protein Heterodimerization Activity
	Biological Process		Glutamate Decarboxylation To Succinate Synaptic Transmission Neurotransmitter Secretion Neurotransmitter Biosynthetic Process Response To Drug
Pathways			Neurotransmitter Release Cycle GABA synthesis GABA synthesis, release, reuptake and degradation Transmission across Chemical Synapses
Drugs			L-Glutamic Acid
Diseases
GWAS		Hippocampal atrophy ( 19668339)
Protein-Protein Interactions		15 interactors: ABCG8 ARFIP2 FAM3A GAD2 PBX3 PPP1CA PTPN9 RAB37 SH3GL1 TBRG4 TPD52 TPD52L1 TPD52L2 TUBB VARS2	9 interactors: AGTRAP ARL6IP1 CMTM5 F10 GAD1 MAL2 PRKACA PRKCE TMEM159
Entrez ID		114569	2572
HPRD ID		14351	11817
Ensembl ID		ENSG00000147676	ENSG00000136750
Uniprot IDs		Q969L2	Q05329 Q5VZ30
PDB IDs			1ES0 2OKK
Enriched GO Terms of Interacting Partners?			Positive Regulation Of Cell Migration Activation Of Phospholipase C Activity Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Positive Regulation Of Phospholipase C Activity Blood Coagulation Hemostasis Positive Regulation Of Phospholipase Activity Positive Regulation Of Epithelial Cell Migration Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Positive Regulation Of Dense Core Granule Biogenesis Positive Regulation Of Cellular Glucuronidation Regulation Of Body Fluid Levels Regulation Of Cell Migration Peptidyl-serine Phosphorylation Wound Healing Glutamate Decarboxylation To Succinate TRAM-dependent Toll-like Receptor 4 Signaling Pathway Protein-pyridoxal-5-phosphate Linkage Histone H3-T6 Phosphorylation Regulation Of Cell Motility Regulation Of Wound Healing Regulation Of Locomotion Regulation Of Ion Transmembrane Transporter Activity Regulation Of Epithelial Cell Migration Regulation Of Transmembrane Transporter Activity Regulation Of Cellular Component Movement Response To Wounding Regulation Of Ion Homeostasis Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Gamma-aminobutyric Acid Biosynthetic Process Cytosolic Calcium Ion Homeostasis Positive Regulation Of Intracellular Signal Transduction Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Platelet Activation Blood Coagulation, Extrinsic Pathway Regulation Of Insulin Secretion Regulation Of Peptidyl-tyrosine Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Regulation Of Peptide Hormone Secretion Positive Regulation Of Cell Cycle Process Neurotrophin Signaling Pathway Glutamate Catabolic Process Peptidyl-serine Autophosphorylation
Tagcloud ?		cease chief he4 imchief immortomice immortomouse imspem lineages metaplasia metaplasias metaplastic myelin nonpermissive owing oxyntic pepsinogen permissive preneoplastic proliferate rab3d reliance resemble secrete sole spasmolytic spem stomach tff2 transdifferentiation	agouti camk2g cd47 chances clstn2 consonant enpp1 epha5a gria3 grin2b kif minipumps myo5a negr1 neuroplasticity ntrk2 ntrk3 ppp3r1 prdx1 predecessors serotonine slc2a4 sv2b syn2 synaptogenesis synj2 therapeutical venlafaxine vlx
Tagcloud (Difference) ?		cease chief he4 imchief immortomice immortomouse imspem lineages metaplasia metaplasias metaplastic myelin nonpermissive owing oxyntic pepsinogen permissive preneoplastic proliferate rab3d reliance resemble secrete sole spasmolytic spem stomach tff2 transdifferentiation	agouti camk2g cd47 chances clstn2 consonant enpp1 epha5a gria3 grin2b kif minipumps myo5a negr1 neuroplasticity ntrk2 ntrk3 ppp3r1 prdx1 predecessors serotonine slc2a4 sv2b syn2 synaptogenesis synj2 therapeutical venlafaxine vlx
Tagcloud (Intersection) ?