MAL2 and NFAM1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MAL2	NFAM1
Description		mal, T cell differentiation protein 2	NFAT activating protein with ITAM motif 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Endomembrane System Membrane Apical Plasma Membrane Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Exosome	Plasma Membrane Membrane Azurophil Granule Membrane Membrane Raft
	Molecular Function	Protein Binding Structural Constituent Of Myelin Sheath	Transmembrane Signaling Receptor Activity Protein Binding
	Biological Process	Myelination	Positive Regulation Of Cytokine Production Inflammatory Response Signal Transduction Cell Surface Receptor Signaling Pathway B Cell Differentiation Calcineurin-NFAT Signaling Cascade Intracellular Signal Transduction Regulation Of B Cell Differentiation B Cell Receptor Signaling Pathway Positive Regulation Of B Cell Receptor Signaling Pathway
Pathways			Neutrophil degranulation
Drugs
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Blood pressure (smoking interaction) ( 25189868) Gallstone disease ( 30504769) Hippocampal atrophy ( 19668339) Osteoprotegerin levels ( 25080503)	Chronotype ( 30696823) Machado-Joseph disease (age at onset) ( 32205469) Refractive error ( 32231278) Risk-taking tendency (4-domain principal component model) ( 30643258)
Interacting Genes		49 interacting genes: ABCG8 AQP6 ARFIP2 ARL13B ATP6V0E1 CD160 CD68 COQ8A CREB3 CREB3L1 ECPAS FAM3A GAD1 GAD2 GJB1 GPR152 HSFX1 HSFX2 MRM1 MTERF3 MUC1 NDRG4 NFAM1 PBX3 PIMREG PITPNC1 POLL PPP1CA PTPN9 RAB37 REEP4 RETREG3 S100B SCN3B SGK1 SH3GL1 SH3GLB1 SHMT2 SLC35H1 SUCLA2 TBRG4 THAP4 TMEM14B TPD52 TPD52L1 TPD52L2 TTPA TUBB VARS2	6 interacting genes: BCL11A CFTR MAL2 SYK TCF4 ZAP70
Entrez ID		114569	150372
HPRD ID		14351	16380
Ensembl ID		ENSG00000147676	ENSG00000235568
Uniprot IDs		Q969L2	Q8NET5
PDB IDs
Enriched GO Terms of Interacting Partners?		Succinate Metabolic Process Gamma-aminobutyrate Shunt Glutamate Decarboxylase Activity Gamma-aminobutyric Acid Biosynthetic Process	Beta Selection Positive Regulation Of Developmental Process Regulation Of Developmental Process T Cell Selection Positive Regulation Of Alpha-beta T Cell Proliferation T Cell Receptor Complex Regulation Of Multicellular Organismal Development Regulation Of Cell Differentiation Non-membrane Spanning Protein Tyrosine Kinase Activity Positive Regulation Of Alpha-beta T Cell Differentiation Phosphotyrosine Residue Binding Positive Regulation Of Calcium-mediated Signaling Positive Regulation Of Cell Differentiation Leukocyte Cell-cell Adhesion Peptidyl-tyrosine Phosphorylation Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Interleukin-15 Receptor Binding Positive Regulation Of Interleukin-3 Production Positive Regulation Of Alpha-beta T Cell Activation Negative Regulation Of Branching Morphogenesis Of A Nerve Negative Regulation Of Neuron Remodeling Positive Regulation Of Exocytosis Positive Regulation Of Cell Development Regulation Of Calcium-mediated Signaling Positive Regulation Of Anion Channel Activity Positive Regulation Of T Cell Proliferation T Cell Aggregation Transcription Regulatory Region Nucleic Acid Binding Positive Regulation Of Monoatomic Anion Transport Positive Regulation Of T Cell Differentiation Regulation Of Alpha-beta T Cell Activation Serotonin Secretion By Platelet Protein Tyrosine Kinase Activity Beta-catenin-TCF7L2 Complex Negative Regulation Of Protein Homooligomerization Negative Regulation Of Neuron Maturation Collagen Fibril Binding Negative Regulation Of Collagen Fibril Organization Positive Regulation Of Enamel Mineralization T Cell Differentiation Serotonin Secretion Positive Regulation Of Lymphocyte Proliferation Antigen Receptor-mediated Signaling Pathway Cellular Response To Molecule Of Fungal Origin Positive Regulation Of Lymphocyte Differentiation Positive Regulation Of Mononuclear Cell Proliferation B Cell Receptor Complex TFIIB-class Transcription Factor Binding
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