MAL2 and COQ8A

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MAL2	COQ8A
Description		mal, T cell differentiation protein 2	coenzyme Q8A
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Endomembrane System Membrane Apical Plasma Membrane Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Exosome	Mitochondrion Membrane Extrinsic Component Of Mitochondrial Inner Membrane Mitochondrial Membrane
	Molecular Function	Protein Binding Structural Constituent Of Myelin Sheath	Nucleotide Binding Protein Kinase Activity Protein Binding ATP Binding Enzyme Activator Activity Kinase Activity Transferase Activity ADP Binding
	Biological Process	Myelination	Protein Phosphorylation Ubiquinone Biosynthetic Process Phosphorylation
Pathways			Ubiquinol biosynthesis
Drugs			Fostamatinib
Diseases			Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3) Coenzyme Q10 deficiency
GWAS		Aspartate aminotransferase levels ( 33547301) Blood pressure (smoking interaction) ( 25189868) Gallstone disease ( 30504769) Hippocampal atrophy ( 19668339) Osteoprotegerin levels ( 25080503)
Interacting Genes		49 interacting genes: ABCG8 AQP6 ARFIP2 ARL13B ATP6V0E1 CD160 CD68 COQ8A CREB3 CREB3L1 ECPAS FAM3A GAD1 GAD2 GJB1 GPR152 HSFX1 HSFX2 MRM1 MTERF3 MUC1 NDRG4 NFAM1 PBX3 PIMREG PITPNC1 POLL PPP1CA PTPN9 RAB37 REEP4 RETREG3 S100B SCN3B SGK1 SH3GL1 SH3GLB1 SHMT2 SLC35H1 SUCLA2 TBRG4 THAP4 TMEM14B TPD52 TPD52L1 TPD52L2 TTPA TUBB VARS2	27 interacting genes: ABHD5 AGTRAP CCDC34 CMTM4 CMTM5 CMTM6 COQ9 DESI2 DTX2 JOSD2 LDAF1 MAL2 MRM1 MTIF3 ORMDL3 PBX3 RABAC1 REEP6 RPRM SH3GLB1 SMPD2 STX10 TFIP11 TMCO2 TMEM239 TPD52L2 UBC
Entrez ID		114569	56997
HPRD ID		14351	07375
Ensembl ID		ENSG00000147676	ENSG00000163050
Uniprot IDs		Q969L2	Q8NI60
PDB IDs			4PED 5I35 7UDP 7UDQ
Enriched GO Terms of Interacting Partners?		Succinate Metabolic Process Gamma-aminobutyrate Shunt Glutamate Decarboxylase Activity Gamma-aminobutyric Acid Biosynthetic Process
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