CHRNB4 and CHRNA4

Number of citations of the paper that reports this interaction (PMID 8906617)
9

Data Source:
HPRD (in vitro)

		CHRNB4	CHRNA4
Gene Name		cholinergic receptor, nicotinic, beta 4 (neuronal)	cholinergic receptor, nicotinic, alpha 4 (neuronal)
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Acetylcholine-gated Channel Complex Integral Component Of Membrane Cell Junction Postsynaptic Membrane	Plasma Membrane Acetylcholine-gated Channel Complex External Side Of Plasma Membrane Membrane Integral Component Of Membrane Cell Junction Dendrite Neuronal Cell Body Postsynaptic Membrane
	Molecular Function	Acetylcholine-activated Cation-selective Channel Activity Ligand-gated Ion Channel Activity Acetylcholine Receptor Activity	Acetylcholine-activated Cation-selective Channel Activity Ligand-gated Ion Channel Activity Acetylcholine Receptor Activity Acetylcholine Binding
	Biological Process	Action Potential Ion Transport Cation Transport Smooth Muscle Contraction Regulation Of Smooth Muscle Contraction Signal Transduction Synaptic Transmission Synaptic Transmission, Cholinergic Locomotory Behavior Ion Transmembrane Transport Behavioral Response To Nicotine Regulation Of Neurotransmitter Secretion Synaptic Transmission Involved In Micturition Cation Transmembrane Transport	Action Potential Response To Hypoxia DNA Repair Ion Transport Calcium Ion Transport Response To Oxidative Stress Signal Transduction Synaptic Transmission Synaptic Transmission, Cholinergic Respiratory Gaseous Exchange Locomotory Behavior Regulation Of Dopamine Secretion Sensory Perception Of Pain Response To Nicotine Behavioral Response To Nicotine Exploration Behavior B Cell Activation Regulation Of Membrane Potential Neurological System Process Cognition Membrane Depolarization Regulation Of Inhibitory Postsynaptic Membrane Potential Cation Transmembrane Transport
Pathways		Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Acetylcholine Binding And Downstream Events Postsynaptic nicotinic acetylcholine receptors Activation of Nicotinic Acetylcholine Receptors Presynaptic nicotinic acetylcholine receptors Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Highly sodium permeable acetylcholine nicotinic receptors Highly calcium permeable nicotinic acetylcholine receptors Transmission across Chemical Synapses	Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Acetylcholine Binding And Downstream Events Postsynaptic nicotinic acetylcholine receptors Activation of Nicotinic Acetylcholine Receptors Presynaptic nicotinic acetylcholine receptors Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Highly sodium permeable acetylcholine nicotinic receptors Highly calcium permeable nicotinic acetylcholine receptors Transmission across Chemical Synapses
Drugs			Nicotine Butabarbital Butalbital Talbutal Pentobarbital Secobarbital Metharbital Thiopental Galantamine Primidone Methylphenobarbital Phenobarbital Varenicline Amobarbital Aprobarbital Butethal Heptabarbital Hexobarbital Barbital Barbituric acid derivative
Diseases
GWAS		Lung cancer ( 18385738 18780872) Nicotine dependence ( 18385739) Sudden cardiac arrest ( 21658281)	Chronic obstructive pulmonary disease ( 19300482)
Protein-Protein Interactions		5 interactors: CHRNA2 CHRNA3 CHRNA4 CHRNA5 UBQLN1	7 interactors: CHRNB2 CHRNB4 CRELD2 CSNK2B UBQLN1 VSNL1 YWHAH
Entrez ID		1143	1137
HPRD ID		00337	00333
Ensembl ID		ENSG00000117971	ENSG00000101204
Uniprot IDs		P30926	B4DK78 P43681 Q4VAQ3 Q4VAQ5 Q59FV0
PDB IDs		2ASG	2GVT 2LLY
Enriched GO Terms of Interacting Partners?		Behavioral Response To Nicotine Response To Nicotine Synaptic Transmission Response To Alkaloid Synaptic Transmission, Cholinergic Adult Behavior Cell-cell Signaling Cation Transmembrane Transport Cation Transport Ion Transmembrane Transport Single-organism Behavior Regulation Of Postsynaptic Membrane Potential Transmembrane Transport Ion Transport Behavior Membrane Depolarization Regulation Of Anion Transport Response To Organonitrogen Compound Response To Organic Cyclic Compound Synaptic Transmission Involved In Micturition Locomotory Behavior Regulation Of Acetylcholine Secretion, Neurotransmission Regulation Of Membrane Potential Micturition Response To Hypoxia Cellular Response To Stimulus Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Regulation Of Inhibitory Postsynaptic Membrane Potential Regulation Of Dopamine Secretion Response To Stimulus Neuromuscular Synaptic Transmission Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Exploration Behavior Regulation Of Ion Transport Regulation Of Secretion Membrane Hyperpolarization Transport Signal Transduction Excretion Response To Organic Substance Regulation Of Cellular Response To Oxidative Stress Regulation Of Smooth Muscle Contraction Respiratory Gaseous Exchange Signaling Cell Communication Regulation Of Neurotransmitter Secretion Regulation Of Dendrite Morphogenesis Regulation Of Excitatory Postsynaptic Membrane Potential Protein Complex Assembly Regulation Of Cellular Localization	Synaptic Transmission Involved In Micturition Micturition Action Potential Behavioral Response To Nicotine Synaptic Transmission, Cholinergic Neuromuscular Synaptic Transmission Regulation Of Membrane Potential Response To Nicotine Regulation Of Synaptic Transmission Excretion Neural Nucleus Development Smooth Muscle Contraction Regulation Of Dendrite Morphogenesis Regulation Of Signaling Renal System Process Lateral Geniculate Nucleus Development Glucocorticoid Catabolic Process Regulation Of Dendrite Development Membrane Depolarization Cellular Response To Stimulus Response To Alkaloid Adult Behavior Negative Regulation Of Action Potential Muscle Contraction Regulation Of Circadian Sleep/wake Cycle, REM Sleep Positive Regulation Of Dopamine Secretion Locomotory Behavior Regulation Of Cellular Localization Conditioned Taste Aversion Response To Stimulus Muscle System Process Positive Regulation Of Activin Receptor Signaling Pathway Glucocorticoid Receptor Signaling Pathway Adiponectin-activated Signaling Pathway Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Negative Regulation Of Dendrite Morphogenesis Response To Hypoxia Vestibulocochlear Nerve Development Positive Regulation Of Synaptic Transmission, Dopaminergic Optic Nerve Morphogenesis Signal Transduction Endothelial Tube Morphogenesis Positive Regulation Of Catecholamine Secretion Optic Nerve Development Signaling Regulation Of Neuron Projection Development Thalamus Development Cell Communication Negative Regulation Of Dendrite Development Glucocorticoid Metabolic Process
Tagcloud ?		alpha3 alpha3beta4 alpha5 aversion beta4 cholinergic chrna3 chrna5 doubles electrophysiology firing habenula hcn heightened hyperpolarization interpeduncular mhb nicotine nicotinic pacemaker pacemaking peptidergic precipitates reexposure relay tonic translating withdrawal zd7288	adrenal axis bcl1 beck besides carriers cc cholinergic depression depressiveness disruption epistasis genetics genotyped glucocorticoid glucocorticoids homozygous hypothalamic impacts inventory locus means nr3c1 pituitary polymorphisms reactivity rs1044396 rs41423247 showing
Tagcloud (Difference) ?		alpha3 alpha3beta4 alpha5 aversion beta4 chrna3 chrna5 doubles electrophysiology firing habenula hcn heightened hyperpolarization interpeduncular mhb nicotine nicotinic pacemaker pacemaking peptidergic precipitates reexposure relay tonic translating withdrawal zd7288	adrenal axis bcl1 beck besides carriers cc depression depressiveness disruption epistasis genetics genotyped glucocorticoid glucocorticoids homozygous hypothalamic impacts inventory locus means nr3c1 pituitary polymorphisms reactivity rs1044396 rs41423247 showing
Tagcloud (Intersection) ?		cholinergic