CHRNB4 and CHRNA3

Number of citations of the paper that reports this interaction (PMID 1689727)
44

Data Source:
HPRD (in vitro)

		CHRNB4	CHRNA3
Gene Name		cholinergic receptor, nicotinic, beta 4 (neuronal)	cholinergic receptor, nicotinic, alpha 3 (neuronal)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Acetylcholine-gated Channel Complex Integral Component Of Membrane Cell Junction Postsynaptic Membrane	Plasma Membrane Acetylcholine-gated Channel Complex Postsynaptic Density Integral Component Of Membrane Cell Junction Dendrite Neuronal Cell Body Postsynaptic Membrane
	Molecular Function	Acetylcholine-activated Cation-selective Channel Activity Ligand-gated Ion Channel Activity Acetylcholine Receptor Activity	Acetylcholine-activated Cation-selective Channel Activity Ligand-gated Ion Channel Activity Acetylcholine Receptor Activity Acetylcholine Binding
	Biological Process	Action Potential Ion Transport Cation Transport Smooth Muscle Contraction Regulation Of Smooth Muscle Contraction Signal Transduction Synaptic Transmission Synaptic Transmission, Cholinergic Locomotory Behavior Ion Transmembrane Transport Behavioral Response To Nicotine Regulation Of Neurotransmitter Secretion Synaptic Transmission Involved In Micturition Cation Transmembrane Transport	Ion Transport Regulation Of Smooth Muscle Contraction Signal Transduction Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Synaptic Transmission Synaptic Transmission, Cholinergic Nervous System Development Locomotory Behavior Regulation Of Acetylcholine Secretion, Neurotransmission Ion Transmembrane Transport Behavioral Response To Nicotine Regulation Of Membrane Potential Regulation Of Dendrite Morphogenesis Regulation Of Excitatory Postsynaptic Membrane Potential Synaptic Transmission Involved In Micturition Cation Transmembrane Transport
Pathways		Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Acetylcholine Binding And Downstream Events Postsynaptic nicotinic acetylcholine receptors Activation of Nicotinic Acetylcholine Receptors Presynaptic nicotinic acetylcholine receptors Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Highly sodium permeable acetylcholine nicotinic receptors Highly calcium permeable nicotinic acetylcholine receptors Transmission across Chemical Synapses	Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Acetylcholine Binding And Downstream Events Postsynaptic nicotinic acetylcholine receptors Activation of Nicotinic Acetylcholine Receptors Presynaptic nicotinic acetylcholine receptors Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Highly sodium permeable acetylcholine nicotinic receptors Highly calcium permeable nicotinic acetylcholine receptors Transmission across Chemical Synapses
Drugs
Diseases
GWAS		Lung cancer ( 18385738 18780872) Nicotine dependence ( 18385739) Sudden cardiac arrest ( 21658281)	Chronic obstructive pulmonary disease ( 22080838 19300482 20173748) Lung adenocarcinoma ( 19836008) Lung cancer ( 18385676 18385738 19654303 18780872) Nicotine dependence ( 18385739) Obesity-related traits ( 23251661) Pulmonary function ( 21946350) Pulmonary function (interaction) ( 23284291) Serum albumin level ( 23022100) Smoking behavior ( 20418889 20418890)
Protein-Protein Interactions		5 interactors: CHRNA2 CHRNA3 CHRNA4 CHRNA5 UBQLN1	2 interactors: CHRNB4 UBQLN1
Entrez ID		1143	1136
HPRD ID		00337	07511
Ensembl ID		ENSG00000117971	ENSG00000080644
Uniprot IDs		P30926	P32297
PDB IDs		2ASG
Enriched GO Terms of Interacting Partners?		Behavioral Response To Nicotine Response To Nicotine Synaptic Transmission Response To Alkaloid Synaptic Transmission, Cholinergic Adult Behavior Cell-cell Signaling Cation Transmembrane Transport Cation Transport Ion Transmembrane Transport Single-organism Behavior Regulation Of Postsynaptic Membrane Potential Transmembrane Transport Ion Transport Behavior Membrane Depolarization Regulation Of Anion Transport Response To Organonitrogen Compound Response To Organic Cyclic Compound Synaptic Transmission Involved In Micturition Locomotory Behavior Regulation Of Acetylcholine Secretion, Neurotransmission Regulation Of Membrane Potential Micturition Response To Hypoxia Cellular Response To Stimulus Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Regulation Of Inhibitory Postsynaptic Membrane Potential Regulation Of Dopamine Secretion Response To Stimulus Neuromuscular Synaptic Transmission Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Exploration Behavior Regulation Of Ion Transport Regulation Of Secretion Membrane Hyperpolarization Transport Signal Transduction Excretion Response To Organic Substance Regulation Of Cellular Response To Oxidative Stress Regulation Of Smooth Muscle Contraction Respiratory Gaseous Exchange Signaling Cell Communication Regulation Of Neurotransmitter Secretion Regulation Of Dendrite Morphogenesis Regulation Of Excitatory Postsynaptic Membrane Potential Protein Complex Assembly Regulation Of Cellular Localization	Synaptic Transmission Involved In Micturition Micturition Behavioral Response To Nicotine Synaptic Transmission, Cholinergic Neuromuscular Synaptic Transmission Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Response To Nicotine Excretion Regulation Of Cellular Response To Oxidative Stress Regulation Of Smooth Muscle Contraction Smooth Muscle Contraction Regulation Of Neurotransmitter Secretion Action Potential Renal System Process Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels Response To Alkaloid Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Muscle Contraction Response To Endoplasmic Reticulum Stress Adult Behavior Regulation Of Protein Ubiquitination Regulation Of Signaling
Tagcloud ?		alpha3 alpha3beta4 alpha5 aversion beta4 cholinergic chrna3 chrna5 doubles electrophysiology firing habenula hcn heightened hyperpolarization interpeduncular mhb nicotine nicotinic pacemaker pacemaking peptidergic precipitates reexposure relay tonic translating withdrawal zd7288	1x10 9x10 accounts adenocarcinoma b4 clptm1l conducting cyp1a1 dependence genetics gwa mediation nicotine nicotinic personalized rs1051730 rs12914385 rs2736100 rs2853676 rs31489 rs401681 smoking snps tert variations
Tagcloud (Difference) ?		alpha3 alpha3beta4 alpha5 aversion beta4 cholinergic doubles electrophysiology firing habenula hcn heightened hyperpolarization interpeduncular mhb pacemaker pacemaking peptidergic precipitates reexposure relay tonic translating withdrawal zd7288	1x10 9x10 accounts adenocarcinoma b4 clptm1l conducting cyp1a1 dependence genetics gwa mediation personalized rs1051730 rs12914385 rs2736100 rs2853676 rs31489 rs401681 smoking snps tert variations
Tagcloud (Intersection) ?		chrna3 chrna5 nicotine nicotinic