CHRNA2 and CHRNB2

Number of citations of the paper that reports this interaction (PubMedID 8906617)
0

Data Source:
HPRD (in vivo)

		CHRNA2	CHRNB2
Description		cholinergic receptor nicotinic alpha 2 subunit	cholinergic receptor nicotinic beta 2 subunit
Image
GO Annotations	Cellular Component	Nucleoplasm Plasma Membrane Acetylcholine-gated Channel Complex Membrane Protein-containing Complex Cation Channel Complex Neuron Projection Intercellular Bridge Synapse Postsynaptic Membrane Cell Periphery Synaptic Membrane Presynapse Neurotransmitter Receptor Complex Neuron Projection Cytoplasm	Plasma Membrane Acetylcholine-gated Channel Complex External Side Of Plasma Membrane Membrane Cation Channel Complex Neuron Projection Plasma Membrane Raft Synapse Postsynaptic Membrane Synaptic Membrane Neurotransmitter Receptor Complex
	Molecular Function	Transmembrane Signaling Receptor Activity Monoatomic Ion Channel Activity Extracellular Ligand-gated Monoatomic Ion Channel Activity Acetylcholine Receptor Activity Acetylcholine-gated Monoatomic Cation-selective Channel Activity Quaternary Ammonium Group Binding Heterocyclic Compound Binding	Transmembrane Signaling Receptor Activity Monoatomic Ion Channel Activity Extracellular Ligand-gated Monoatomic Ion Channel Activity Protein Binding Ligand-gated Monoatomic Ion Channel Activity Acetylcholine Receptor Activity Acetylcholine-gated Monoatomic Cation-selective Channel Activity Acetylcholine Binding
	Biological Process	Monoatomic Ion Transport Signal Transduction Synaptic Transmission, Cholinergic Neuromuscular Synaptic Transmission Monoatomic Ion Transmembrane Transport Response To Nicotine Regulation Of Synaptic Plasticity Membrane Depolarization Regulation Of Postsynaptic Membrane Potential Excitatory Postsynaptic Potential Cellular Response To Nicotine Acetylcholine Receptor Signaling Pathway Modulation Of Inhibitory Postsynaptic Potential Presynaptic Modulation Of Chemical Synaptic Transmission Response To Acetylcholine	Response To Hypoxia Monoatomic Ion Transport Calcium Ion Transport Smooth Muscle Contraction Signal Transduction Chemical Synaptic Transmission Synaptic Transmission, Cholinergic Visual Perception Sensory Perception Of Sound Learning Memory Locomotory Behavior Associative Learning Visual Learning Regulation Of Dopamine Secretion Sensory Perception Of Pain Vestibulocochlear Nerve Development Optic Nerve Morphogenesis Lateral Geniculate Nucleus Development Central Nervous System Projection Neuron Axonogenesis Positive Regulation Of B Cell Proliferation Regulation Of Synaptic Transmission, Dopaminergic Positive Regulation Of Dopamine Secretion Monoatomic Ion Transmembrane Transport Response To Nicotine Behavioral Response To Nicotine Social Behavior Regulation Of Dopamine Metabolic Process B Cell Activation Response To Cocaine Regulation Of Circadian Sleep/wake Cycle, REM Sleep Response To Ethanol Negative Regulation Of Action Potential Regulation Of Dendrite Morphogenesis Nervous System Process Cognition Membrane Depolarization Regulation Of Synapse Assembly Regulation Of Postsynaptic Membrane Potential Excitatory Postsynaptic Potential Synaptic Transmission Involved In Micturition Acetylcholine Receptor Signaling Pathway Response To Acetylcholine
Pathways		Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Highly calcium permeable nicotinic acetylcholine receptors	Highly sodium permeable postsynaptic acetylcholine nicotinic receptors Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Highly calcium permeable nicotinic acetylcholine receptors
Drugs		Nicotine Succinylcholine Butabarbital Carbamoylcholine Metocurine iodide Fluoxetine Gallamine triethiodide Dextromethorphan Cisatracurium Mecamylamine Procaine Rocuronium Atracurium besylate Ethanol Doxacurium Tubocurarine Mivacurium Decamethonium Metocurine Pancuronium Pipecuronium Vecuronium RPI-78M Epibatidine Hexamethonium	Nicotine Succinylcholine Butabarbital Methadone Dextromethorphan Cisatracurium Atropine Mecamylamine Scopolamine Isoflurane Ethanol Physostigmine Decamethonium Varenicline Pozanicline RPI-78M Rivanicline Epibatidine Cytisine
Diseases		Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE); Nocturnal frontal lobe epilepsy (NFLE)	Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE); Nocturnal frontal lobe epilepsy (NFLE)
GWAS		Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Autism spectrum disorder or schizophrenia ( 28540026) Cannabis use disorder ( 31209380 33096046) Lung cancer ( 28604730) Response to zileuton treatment in asthma (FEV1 change interaction) ( 26031901) Schizophrenia ( 29483656) Smoking status (current vs mixed) ( 33082346) Smoking status (current vs never) ( 33082346)	Lung function (FEV1) ( 30175238) Nicotine dependence ( 28440896) Smoking behaviour (cigarettes smoked per day) ( 30679032)
Interacting Genes		2 interacting genes: CHRNB2 CHRNB4	4 interacting genes: CHRNA2 CHRNA4 CRELD2 SNCA
Entrez ID		1135	1141
HPRD ID		00332	00335
Ensembl ID		ENSG00000120903	ENSG00000160716
Uniprot IDs		Q15822	P17787 Q5SXY3
PDB IDs		5FJV	2K58 2K59 2KSR 2LM2 5KXI 6CNJ 6CNK 6UR8 6USF 8SSZ 8ST0 8ST1 8ST2 8ST3 8ST4
Enriched GO Terms of Interacting Partners?		Synaptic Transmission Involved In Micturition Acetylcholine Receptor Activity Neurotransmitter Receptor Complex Behavioral Response To Nicotine Acetylcholine-gated Monoatomic Cation-selective Channel Activity Acetylcholine-gated Channel Complex Cation Channel Complex Synaptic Transmission, Cholinergic Ligand-gated Monoatomic Ion Channel Activity Neuromuscular Synaptic Transmission Extracellular Ligand-gated Monoatomic Ion Channel Activity Response To Nicotine Acetylcholine Receptor Signaling Pathway Postsynaptic Signal Transduction Membrane Depolarization Smooth Muscle Contraction Excitatory Postsynaptic Potential Synaptic Membrane Regulation Of Postsynaptic Membrane Potential Adult Behavior Monoatomic Ion Channel Activity Lateral Geniculate Nucleus Development Locomotory Behavior Muscle Contraction Transmembrane Signaling Receptor Activity Postsynaptic Membrane Muscle System Process Chemical Synaptic Transmission Neuron Projection Trans-synaptic Signaling Synaptic Signaling Vestibulocochlear Nerve Development Regulation Of Circadian Sleep/wake Cycle, REM Sleep Optic Nerve Morphogenesis Negative Regulation Of Action Potential Regulation Of Membrane Potential Positive Regulation Of Dopamine Secretion Modulation Of Chemical Synaptic Transmission Positive Regulation Of Transmission Of Nerve Impulse Regulation Of Synaptic Transmission, Dopaminergic Acetylcholine Binding Regulation Of Secretion By Cell Response To Acetylcholine Cell-cell Signaling Cholinergic Synapse Regulation Of Secretion Signaling Positive Regulation Of Catecholamine Secretion Cell Communication Cranial Nerve Morphogenesis	Excitatory Postsynaptic Potential Regulation Of Postsynaptic Membrane Potential Acetylcholine-gated Monoatomic Cation-selective Channel Activity Acetylcholine Receptor Activity Acetylcholine-gated Channel Complex Neurotransmitter Receptor Complex Cation Channel Complex Synaptic Transmission, Cholinergic Regulation Of Dopamine Secretion Trans-synaptic Signaling Extracellular Ligand-gated Monoatomic Ion Channel Activity Presynaptic Modulation Of Chemical Synaptic Transmission Synaptic Signaling Neuromuscular Synaptic Transmission Chemical Synaptic Transmission Regulation Of Catecholamine Secretion Response To Nicotine Acetylcholine Receptor Signaling Pathway Postsynaptic Signal Transduction Membrane Depolarization Regulation Of Membrane Potential Synaptic Membrane Modulation Of Chemical Synaptic Transmission Regulation Of Amine Transport Cell-cell Signaling Neuron Projection Cytoplasm Signaling Cell Communication Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Adult Behavior Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Monoatomic Ion Channel Activity Synapse Quaternary Ammonium Group Binding Negative Regulation Of Serotonin Uptake Transporter Regulator Activity Negative Regulation Of Chaperone-mediated Autophagy Regulation Of Synaptic Plasticity Negative Regulation Of Dopamine Metabolic Process Regulation Of Serotonin Uptake Transmembrane Signaling Receptor Activity Presynapse Postsynaptic Membrane Negative Regulation Of Thrombin-activated Receptor Signaling Pathway
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