CHRNA2

Description		cholinergic receptor nicotinic alpha 2 subunit
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GO Annotations	Cellular Component	Nucleoplasm Plasma Membrane Acetylcholine-gated Channel Complex Membrane Protein-containing Complex Cation Channel Complex Neuron Projection Intercellular Bridge Synapse Postsynaptic Membrane Cell Periphery Synaptic Membrane Presynapse Neurotransmitter Receptor Complex Neuron Projection Cytoplasm
	Molecular Function	Transmembrane Signaling Receptor Activity Monoatomic Ion Channel Activity Extracellular Ligand-gated Monoatomic Ion Channel Activity Acetylcholine Receptor Activity Acetylcholine-gated Monoatomic Cation-selective Channel Activity Quaternary Ammonium Group Binding Heterocyclic Compound Binding
	Biological Process	Monoatomic Ion Transport Signal Transduction Synaptic Transmission, Cholinergic Neuromuscular Synaptic Transmission Monoatomic Ion Transmembrane Transport Response To Nicotine Regulation Of Synaptic Plasticity Membrane Depolarization Regulation Of Postsynaptic Membrane Potential Excitatory Postsynaptic Potential Cellular Response To Nicotine Acetylcholine Receptor Signaling Pathway Modulation Of Inhibitory Postsynaptic Potential Presynaptic Modulation Of Chemical Synaptic Transmission Response To Acetylcholine
Pathways		Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Highly calcium permeable nicotinic acetylcholine receptors
Drugs		Nicotine Succinylcholine Butabarbital Carbamoylcholine Metocurine iodide Fluoxetine Gallamine triethiodide Dextromethorphan Cisatracurium Mecamylamine Procaine Rocuronium Atracurium besylate Ethanol Doxacurium Tubocurarine Mivacurium Decamethonium Metocurine Pancuronium Pipecuronium Vecuronium RPI-78M Epibatidine Hexamethonium
Diseases		Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE); Nocturnal frontal lobe epilepsy (NFLE)
GWAS		Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Autism spectrum disorder or schizophrenia ( 28540026) Cannabis use disorder ( 31209380 33096046) Lung cancer ( 28604730) Response to zileuton treatment in asthma (FEV1 change interaction) ( 26031901) Schizophrenia ( 29483656) Smoking status (current vs mixed) ( 33082346) Smoking status (current vs never) ( 33082346)
Interacting Genes		2 interacting genes: CHRNB2 CHRNB4
Entrez ID		1135
HPRD ID		00332
Ensembl ID		ENSG00000120903
Uniprot IDs		Q15822
PDB IDs		5FJV
Enriched GO Terms of Interacting Partners?		Synaptic Transmission Involved In Micturition Acetylcholine Receptor Activity Neurotransmitter Receptor Complex Behavioral Response To Nicotine Acetylcholine-gated Monoatomic Cation-selective Channel Activity Acetylcholine-gated Channel Complex Cation Channel Complex Synaptic Transmission, Cholinergic Ligand-gated Monoatomic Ion Channel Activity Neuromuscular Synaptic Transmission Extracellular Ligand-gated Monoatomic Ion Channel Activity Response To Nicotine Acetylcholine Receptor Signaling Pathway Postsynaptic Signal Transduction Membrane Depolarization Smooth Muscle Contraction Excitatory Postsynaptic Potential Synaptic Membrane Regulation Of Postsynaptic Membrane Potential Adult Behavior Monoatomic Ion Channel Activity Lateral Geniculate Nucleus Development Locomotory Behavior Muscle Contraction Transmembrane Signaling Receptor Activity Postsynaptic Membrane Muscle System Process Chemical Synaptic Transmission Neuron Projection Trans-synaptic Signaling Synaptic Signaling Vestibulocochlear Nerve Development Regulation Of Circadian Sleep/wake Cycle, REM Sleep Optic Nerve Morphogenesis Negative Regulation Of Action Potential Regulation Of Membrane Potential Positive Regulation Of Dopamine Secretion Modulation Of Chemical Synaptic Transmission Positive Regulation Of Transmission Of Nerve Impulse Regulation Of Synaptic Transmission, Dopaminergic Acetylcholine Binding Regulation Of Secretion By Cell Response To Acetylcholine Cell-cell Signaling Cholinergic Synapse Regulation Of Secretion Signaling Positive Regulation Of Catecholamine Secretion Cell Communication Cranial Nerve Morphogenesis
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