CHRNA2 and CHRNB4

Number of citations of the paper that reports this interaction (PMID 8906617)
9

Data Source:
HPRD (in vitro, in vivo)

		CHRNA2	CHRNB4
Gene Name		cholinergic receptor, nicotinic, alpha 2 (neuronal)	cholinergic receptor, nicotinic, beta 4 (neuronal)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Acetylcholine-gated Channel Complex Integral Component Of Membrane Cell Junction Postsynaptic Membrane	Plasma Membrane Integral Component Of Plasma Membrane Acetylcholine-gated Channel Complex Integral Component Of Membrane Cell Junction Postsynaptic Membrane
	Molecular Function	Acetylcholine-activated Cation-selective Channel Activity Drug Binding Acetylcholine Receptor Activity Acetylcholine Binding	Acetylcholine-activated Cation-selective Channel Activity Ligand-gated Ion Channel Activity Acetylcholine Receptor Activity
	Biological Process	Ion Transport Cation Transport Signal Transduction Synaptic Transmission Protein Heterooligomerization Cation Transmembrane Transport	Action Potential Ion Transport Cation Transport Smooth Muscle Contraction Regulation Of Smooth Muscle Contraction Signal Transduction Synaptic Transmission Synaptic Transmission, Cholinergic Locomotory Behavior Ion Transmembrane Transport Behavioral Response To Nicotine Regulation Of Neurotransmitter Secretion Synaptic Transmission Involved In Micturition Cation Transmembrane Transport
Pathways		Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Acetylcholine Binding And Downstream Events Activation of Nicotinic Acetylcholine Receptors Postsynaptic nicotinic acetylcholine receptors Presynaptic nicotinic acetylcholine receptors Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Highly calcium permeable nicotinic acetylcholine receptors Transmission across Chemical Synapses	Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Acetylcholine Binding And Downstream Events Postsynaptic nicotinic acetylcholine receptors Activation of Nicotinic Acetylcholine Receptors Presynaptic nicotinic acetylcholine receptors Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Highly sodium permeable acetylcholine nicotinic receptors Highly calcium permeable nicotinic acetylcholine receptors Transmission across Chemical Synapses
Drugs		Nicotine Carbachol Metocurine Iodide Gallamine Triethiodide Dextromethorphan Cisatracurium Besylate Mecamylamine Galantamine Procaine Rocuronium Atracurium Biperiden Doxacurium chloride Tubocurarine Mivacurium Decamethonium Metocurine Pancuronium Pipecuronium Vecuronium
Diseases
GWAS			Lung cancer ( 18385738 18780872) Nicotine dependence ( 18385739) Sudden cardiac arrest ( 21658281)
Protein-Protein Interactions		2 interactors: CHRNB2 CHRNB4	5 interactors: CHRNA2 CHRNA3 CHRNA4 CHRNA5 UBQLN1
Entrez ID		1135	1143
HPRD ID		00332	00337
Ensembl ID		ENSG00000120903	ENSG00000117971
Uniprot IDs		B4DK19 J3KMY9 Q15822	P30926
PDB IDs			2ASG
Enriched GO Terms of Interacting Partners?		Synaptic Transmission Involved In Micturition Micturition Behavioral Response To Nicotine Synaptic Transmission, Cholinergic Neuromuscular Synaptic Transmission Response To Nicotine Excretion Smooth Muscle Contraction Action Potential Renal System Process Response To Alkaloid Adult Behavior Lateral Geniculate Nucleus Development Muscle Contraction Locomotory Behavior Muscle System Process Regulation Of Membrane Potential Regulation Of Synaptic Transmission Negative Regulation Of Action Potential Single-organism Behavior Regulation Of Circadian Sleep/wake Cycle, REM Sleep Positive Regulation Of Dopamine Secretion Conditioned Taste Aversion Synaptic Transmission Behavior Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Positive Regulation Of Synaptic Transmission, Dopaminergic Vestibulocochlear Nerve Development Regulation Of Secretion Optic Nerve Morphogenesis Positive Regulation Of Catecholamine Secretion Optic Nerve Development Thalamus Development Response To Organonitrogen Compound Response To Organic Cyclic Compound Regulation Of Circadian Sleep/wake Cycle, Sleep Regulation Of Synaptic Transmission, Dopaminergic Cell-cell Signaling Cation Transmembrane Transport Regulation Of Dopamine Metabolic Process Regulation Of Dopamine Secretion Regulation Of Cellular Localization Cation Transport Ion Transmembrane Transport Positive Regulation Of B Cell Proliferation Central Nervous System Projection Neuron Axonogenesis Social Behavior Response To Cocaine Regulation Of Smooth Muscle Contraction Neural Nucleus Development	Behavioral Response To Nicotine Response To Nicotine Synaptic Transmission Response To Alkaloid Synaptic Transmission, Cholinergic Adult Behavior Cell-cell Signaling Cation Transmembrane Transport Cation Transport Ion Transmembrane Transport Single-organism Behavior Regulation Of Postsynaptic Membrane Potential Transmembrane Transport Ion Transport Behavior Membrane Depolarization Regulation Of Anion Transport Response To Organonitrogen Compound Response To Organic Cyclic Compound Synaptic Transmission Involved In Micturition Locomotory Behavior Regulation Of Acetylcholine Secretion, Neurotransmission Regulation Of Membrane Potential Micturition Response To Hypoxia Cellular Response To Stimulus Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Regulation Of Inhibitory Postsynaptic Membrane Potential Regulation Of Dopamine Secretion Response To Stimulus Neuromuscular Synaptic Transmission Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Exploration Behavior Regulation Of Ion Transport Regulation Of Secretion Membrane Hyperpolarization Transport Signal Transduction Excretion Response To Organic Substance Regulation Of Cellular Response To Oxidative Stress Regulation Of Smooth Muscle Contraction Respiratory Gaseous Exchange Signaling Cell Communication Regulation Of Neurotransmitter Secretion Regulation Of Dendrite Morphogenesis Regulation Of Excitatory Postsynaptic Membrane Potential Protein Complex Assembly Regulation Of Cellular Localization
Tagcloud ?		a432t a452v ankk1 arrb2 cdh13 dbh dnm1 drd2 eas fagerstrom gabbr2 grin3a mstcc n549s nrxn1 nrxn2 nrxn3 ntrk2 r480h rs139982841 rs142807401 rs34755188 rs75981117 skat tas2r38 v132l v389l wss	alpha3 alpha3beta4 alpha5 aversion beta4 cholinergic chrna3 chrna5 doubles electrophysiology firing habenula hcn heightened hyperpolarization interpeduncular mhb nicotine nicotinic pacemaker pacemaking peptidergic precipitates reexposure relay tonic translating withdrawal zd7288
Tagcloud (Difference) ?		a432t a452v ankk1 arrb2 cdh13 dbh dnm1 drd2 eas fagerstrom gabbr2 grin3a mstcc n549s nrxn1 nrxn2 nrxn3 ntrk2 r480h rs139982841 rs142807401 rs34755188 rs75981117 skat tas2r38 v132l v389l wss	alpha3 alpha3beta4 alpha5 aversion beta4 cholinergic chrna3 chrna5 doubles electrophysiology firing habenula hcn heightened hyperpolarization interpeduncular mhb nicotine nicotinic pacemaker pacemaking peptidergic precipitates reexposure relay tonic translating withdrawal zd7288
Tagcloud (Intersection) ?