MGLL and HTR4

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		MGLL	HTR4
Description		monoglyceride lipase	5-hydroxytryptamine receptor 4
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GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane	Cytoplasm Endosome Plasma Membrane Endosome Membrane Membrane Dendrite Postsynapse Glutamatergic Synapse
	Molecular Function	Phosphatidylcholine Lysophospholipase Activity Protein Binding Hydrolase Activity Protein Homodimerization Activity Monoacylglycerol Lipase Activity Carboxylic Ester Hydrolase Activity	G Protein-coupled Receptor Activity G Protein-coupled Serotonin Receptor Activity Protein Binding Neurotransmitter Receptor Activity Serotonin Binding Serotonin Receptor Activity
	Biological Process	Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Inflammatory Response Regulation Of Signal Transduction Lipid Catabolic Process Arachidonate Metabolic Process Triglyceride Catabolic Process Acylglycerol Catabolic Process Regulation Of Inflammatory Response Regulation Of Sensory Perception Of Pain Monoacylglycerol Catabolic Process Regulation Of Endocannabinoid Signaling Pathway	System Process Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating Serotonin Receptor Signaling Pathway Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Chemical Synaptic Transmission Maintenance Of Gastrointestinal Epithelium Regulation Of Appetite Mucus Secretion Large Intestinal Transit Regulation Of Postsynapse Assembly
Pathways		Acyl chain remodeling of DAG and TAG Triglyceride catabolism Arachidonate production from DAG MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	Serotonin receptors G alpha (s) signalling events
Drugs			Dihydroergotamine Cisapride Paroxetine Ondansetron Ergoloid mesylate Tegaserod Metoclopramide Chlorprothixene Piboserod Renzapride Naronapride TD-2749 Ticalopride Prucalopride Cinitapride Setiptiline Dihydroergocornine Gilteritinib Velusetrag Tiapride Dihydroergocristine
Diseases
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Carotid intima media thickness x smoking interaction ( 32117412) Femur bone mineral density x serum urate levels interaction ( 34046847) Pars triangularis volume ( 31530798) Refractive error ( 32231278)	Airflow obstruction ( 22837378) Chronic obstructive pulmonary disease ( 30804561 28166215) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Diastolic blood pressure ( 30578418) FEV1 ( 30804560) Hematocrit ( 32888494) Hemoglobin ( 32888494) Lung function (FEV1) ( 28166213) Lung function (FEV1/FVC) ( 28166213 30804560) Lung function (FVC) ( 30804560) Lung function (low FEV1 vs high FEV1) ( 26423011) Lung function in heavy smokers (low FEV1 vs high FEV1) ( 26423011) Medication use (adrenergics, inhalants) ( 31015401) Mood instability ( 31168069) Peak expiratory flow ( 30804560) Periodontal microbiota ( 22699663) Pulmonary function ( 20010835 20010834) Pulmonary function (smoking interaction) ( 23284291) Systolic blood pressure ( 30578418) Urinary sodium excretion ( 31409800)
Interacting Genes		26 interacting genes: ADRB2 AQP6 CD79A CHGB COQ9 EBAG9 FAM209A FCER1G GEM GOLT1A GPR152 HSD17B13 HTR4 LMNA LTB4R2 MSRB3 PEX12 SDCBP SLC10A6 SLC18A1 SLC66A2 SLC71A2 SLC7A14 STOM TMEM35A TMX2	18 interacting genes: ADRB2 ANO10 CD81 CERS1 CLDN10 CLTB ELOVL5 GDF1 GGT7 GHITM GPR37 GPRIN2 MGLL SARAF SLC39A1 TMEFF2 TMEM230 TSPAN7
Entrez ID		11343	3360
HPRD ID		17574	09074
Ensembl ID		ENSG00000074416	ENSG00000164270
Uniprot IDs		A0A0C4DFN3 B2ZGL7 Q99685	A0A2D3FAF9 Q13639
PDB IDs		3HJU 3JW8 3JWE 3PE6 4UUQ 5ZUN 6AX1 6BQ0 7L4T 7L4U 7L4W 7L50 7PRM 7ZPG 8AQF 8PTC 8PTQ 8PTR 8RVF 9F8A 9F8B 9F8C 9F8D 9FY5	5EM9 7XT8 7XT9 7XTA
Enriched GO Terms of Interacting Partners?			Membrane Endoplasmic Reticulum Membrane
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