MGLL and MSRB3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MGLL	MSRB3
Description		monoglyceride lipase	methionine sulfoxide reductase B3
Image
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane	Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol
	Molecular Function	Phosphatidylcholine Lysophospholipase Activity Protein Binding Hydrolase Activity Protein Homodimerization Activity Monoacylglycerol Lipase Activity Carboxylic Ester Hydrolase Activity	Protein Binding Zinc Ion Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On A Sulfur Group Of Donors, Disulfide As Acceptor Peptide-methionine (R)-S-oxide Reductase Activity L-methionine-(R)-S-oxide Reductase Activity Metal Ion Binding
	Biological Process	Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Inflammatory Response Regulation Of Signal Transduction Lipid Catabolic Process Arachidonate Metabolic Process Triglyceride Catabolic Process Acylglycerol Catabolic Process Regulation Of Inflammatory Response Regulation Of Sensory Perception Of Pain Monoacylglycerol Catabolic Process Regulation Of Endocannabinoid Signaling Pathway	Response To Oxidative Stress Protein Repair
Pathways		Acyl chain remodeling of DAG and TAG Triglyceride catabolism Arachidonate production from DAG MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	Protein repair
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Carotid intima media thickness x smoking interaction ( 32117412) Femur bone mineral density x serum urate levels interaction ( 34046847) Pars triangularis volume ( 31530798) Refractive error ( 32231278)	A body shape index ( 34021172) Antisaccade task score ( 31596458) Appendicular lean mass ( 33097823) Birth weight ( 31043758) Brain morphology (MOSTest) ( 32665545) Cortical surface area ( 32963231) Cortical volume ( 32963231) Dentate gyrus granule cell layer volume ( 30279459) Dentate gyrus molecular layer volume ( 30279459) Differentiated thyroid cancer ( 28703219) FEV1 ( 30804560) General risk tolerance (MTAG) ( 30643258) Heel bone mineral density ( 30598549) Heel bone mineral density x serum urate levels interaction ( 34046847) Height ( 31562340) Hippocampal fissure volume ( 30279459) Hippocampal subfield CA1 volume ( 30279459) Hippocampal subfield CA1 volume (corrected for total hippocampal volume) ( 30279459) Hippocampal subfield CA3 volume ( 30279459) Hippocampal subfield CA4 volume ( 30279459) Hippocampal volume ( 28098162 22504421) Lung function (FEV1) ( 28166213) Lung function (FVC) ( 30804560) Papillary thyroid cancer ( 28703219) Peak expiratory flow ( 30804560) Post bronchodilator FEV1/FVC ratio ( 26634245) Primary tooth development (number of teeth) ( 20195514 23704328) Primary tooth development (time to first tooth eruption) ( 20195514 23704328) Subcortical brain region volumes ( 25607358) Subiculum volume ( 30279459) Temperament ( 22832960) Temporal lobe volume ( 31396565) Total hippocampal volume ( 30279459) Type 2 diabetes nephropathy ( 21150874)
Interacting Genes		26 interacting genes: ADRB2 AQP6 CD79A CHGB COQ9 EBAG9 FAM209A FCER1G GEM GOLT1A GPR152 HSD17B13 HTR4 LMNA LTB4R2 MSRB3 PEX12 SDCBP SLC10A6 SLC18A1 SLC66A2 SLC71A2 SLC7A14 STOM TMEM35A TMX2	31 interacting genes: ASB13 BANP EEF1AKMT3 EFEMP1 EIF6 FAM168B FHL3 GOLGA2 KRT31 KRT34 KRT40 LCN2 LNX2 MAPK8IP2 MED12L METTL15 METTL21A MGLL PICK1 PLEKHG4 POU6F2 PRDM4 REL SKIC8 TCF4 TRIM23 TRIM55 TRIM63 TRIP6 UFSP1 ZMYND12
Entrez ID		11343	253827
HPRD ID		17574	14785
Ensembl ID		ENSG00000074416	ENSG00000174099
Uniprot IDs		A0A0C4DFN3 B2ZGL7 Q99685	Q8IXL7
PDB IDs		3HJU 3JW8 3JWE 3PE6 4UUQ 5ZUN 6AX1 6BQ0 7L4T 7L4U 7L4W 7L50 7PRM 7ZPG 8AQF 8PTC 8PTQ 8PTR 8RVF 9F8A 9F8B 9F8C 9F8D 9FY5	6QA0
Enriched GO Terms of Interacting Partners?			Intermediate Filament Structural Constituent Of Skin Epidermis Structural Molecule Activity Intermediate Filament Organization Methyltransferase Activity Protein Modification Process Protein Binding Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Methylation
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