EXOSC8 and CAB39L

		EXOSC8	CAB39L
Description		exosome component 8	calcium binding protein 39 like
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GO Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Fibrillar Center Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Cytosol Nucleolar Exosome (RNase Complex) Exoribonuclease Complex	Cytoplasm Cytosol Serine/threonine Protein Kinase Complex
	Molecular Function	RNA Binding RNA Exonuclease Activity Protein Binding MRNA 3'-UTR AU-rich Region Binding Identical Protein Binding	Protein Binding Protein Serine/threonine Kinase Activator Activity
	Biological Process	Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RRNA Processing RNA Processing RNA Catabolic Process RRNA Catabolic Process U1 SnRNA 3'-end Processing U4 SnRNA 3'-end Processing U5 SnRNA 3'-end Processing Nuclear MRNA Surveillance Nuclear Polyadenylation-dependent RRNA Catabolic Process TRAMP-dependent TRNA Surveillance Pathway	Intracellular Signal Transduction
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol Nuclear RNA decay	Energy dependent regulation of mTOR by LKB1-AMPK
Drugs
Diseases
GWAS			Appendicular lean mass ( 33097823) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Heel bone mineral density x serum urate levels interaction ( 34046847) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) PR interval ( 32439900)
Interacting Genes		112 interacting genes: AEN ANKHD1 ATF2 C22orf39 CCDC28A-AS1 CCL14 CCSER2 CNNM3 COL23A1 COX5A CPSF7 CRMP1 CWC22 DDIT4L DIS3 DUSP23 ERAL1 EXOSC1 EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC9 FAM161B FAM90A1 FHOD1 FOXD4L1 FOXN3 FRG1 FSAF1 FYTTD1 GEM HAPLN2 HOXB9 ILF2 INCA1 KANK2 KCNJ11 LENG1 LMO4 LNX1 LSM1 LSM4 LSM7 MACIR METTL14 MKRN1 MORN4 MRPL2 MTREX MYOZ1 NEDD9 NTAQ1 NXF1 OTUD4 PACSIN2 PALS2 PHF21A PIAS2 PKP2 POLDIP3 PRC1 PRPF31 PRPF6 PRR3 RASD1 RASSF1 RBBP4 RBM22 RBM7 REL RFC5 RPL3 RPLP0 RPP14 RPS28 RUSC1 RXRB SARNP SF1 SFPQ SGO2 SLAIN1 SLIRP SNAI1 SNRPA SNRPB SNRPC SNRPN SNW1 SOCS7 SPATC1L SRPK2 SRSF10 SUGP2 TBRG1 TCEA2 TFAP4 TFIP11 TXNDC17 TXNDC9 UBC UNKL UPF2 USP2 USP6 UTP14A XRN1 XRN2 ZFP36	4 interacting genes: CFTR MLH1 MX1 SCML2
Entrez ID		11340	81617
HPRD ID		09351	12993
Ensembl ID		ENSG00000120699	ENSG00000102547
Uniprot IDs		Q96B26	Q86WE6 Q9H9S4
PDB IDs		2NN6 6D6Q 6D6R 6H25 9G8M 9G8N 9G8O 9G8P	3ZHP
Enriched GO Terms of Interacting Partners?		RNA Binding MRNA Metabolic Process Exosome (RNase Complex) RNA Processing RNA Metabolic Process Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Nucleic Acid Metabolic Process Nucleolar Exosome (RNase Complex) RNA Splicing, Via Transesterification Reactions Nucleus Nuclear-transcribed MRNA Catabolic Process Nuclear MRNA Surveillance RNA Catabolic Process MRNA Splicing, Via Spliceosome MRNA Catabolic Process RNA Exonuclease Activity MRNA Processing RNA Splicing Nucleoplasm Nucleobase-containing Compound Metabolic Process Spliceosomal Complex Nuclear RNA Surveillance U4 SnRNA 3'-end Processing RNA Surveillance RRNA Catabolic Process 3'-5'-RNA Exonuclease Activity Nucleobase-containing Compound Catabolic Process Nucleic Acid Binding SnRNA Metabolic Process RRNA Metabolic Process RRNA Processing Catalytic Step 2 Spliceosome Poly(A)-dependent SnoRNA 3'-end Processing SnRNA 3'-end Processing Ribonucleoprotein Complex U4/U6 X U5 Tri-snRNP Complex Macromolecule Metabolic Process Nucleolus Exoribonuclease Complex Negative Regulation Of Macromolecule Metabolic Process Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance TRAMP-dependent TRNA Surveillance Pathway Nuclear Polyadenylation-dependent RRNA Catabolic Process Sno(s)RNA Metabolic Process SnRNA Processing RNA 3'-end Processing Negative Regulation Of Macromolecule Biosynthetic Process Protein Binding	Positive Regulation Of Anion Channel Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Monoatomic Anion Transport Meiotic Spindle Midzone Assembly Meiotic Metaphase Chromosome Alignment Male Meiosis Chromosome Segregation MutLalpha Complex Chiasma Nuclear-transcribed MRNA Catabolic Process Late Recombination Nodule MRNA Catabolic Process Meiotic Metaphase I Homologous Chromosome Alignment U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Positive Regulation Of Enamel Mineralization Transepithelial Water Transport Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Positive Regulation Of Isotype Switching To IgA Isotypes RNA Catabolic Process Guanine/thymine Mispair Binding MutSalpha Complex Binding Homologous Chromosome Segregation Female Meiosis Chromosome Segregation Regulation Of Mitotic Recombination Meiotic Telomere Clustering Mismatch Repair Complex Negative Regulation Of Mitotic Recombination Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation Interleukin-27-mediated Signaling Pathway Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Exoribonuclease Complex Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRAMP-dependent TRNA Surveillance Pathway TRNA Surveillance U4 SnRNA 3'-end Processing Nuclear Polyadenylation-dependent RRNA Catabolic Process Amelogenesis Telomere Localization ATPase-coupled Inorganic Anion Transmembrane Transporter Activity RRNA 3'-end Processing Nucleolar Exosome (RNase Complex) Mismatched DNA Binding
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