CHRNA1 and ITGA7

Number of citations of the paper that reports this interaction (PMID 10910772)
21

Data Source:
HPRD (in vivo)

		CHRNA1	ITGA7
Gene Name		cholinergic receptor, nicotinic, alpha 1 (muscle)	integrin, alpha 7
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Acetylcholine-gated Channel Complex Cell Surface Cell Junction Neuromuscular Junction Postsynaptic Membrane	Cytoplasm Plasma Membrane Muscle Tendon Junction Cell Surface Neuromuscular Junction Integrin Alpha7-beta1 Complex Sarcolemma
	Molecular Function	Acetylcholine-activated Cation-selective Channel Activity Ion Channel Activity Acetylcholine Receptor Activity Acetylcholine Binding	Integrin Binding Laminin Binding Metal Ion Binding Protein Heterodimerization Activity
	Biological Process	Skeletal Muscle Contraction Transport Signal Transduction Synaptic Transmission Neuromuscular Synaptic Transmission Neuromuscular Junction Development Neuronal Action Potential Ion Transmembrane Transport Regulation Of Membrane Potential Muscle Cell Cellular Homeostasis Skeletal Muscle Tissue Growth Musculoskeletal Movement Neuromuscular Process Neuron Cellular Homeostasis Cation Transmembrane Transport	Cell-matrix Adhesion Integrin-mediated Signaling Pathway Muscle Organ Development Skeletal Muscle Tissue Development Regulation Of Cell Shape Cell Migration Extracellular Matrix Organization Heterotypic Cell-cell Adhesion Endodermal Cell Differentiation Blood Vessel Morphogenesis
Pathways		Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Acetylcholine Binding And Downstream Events Activation of Nicotinic Acetylcholine Receptors Postsynaptic nicotinic acetylcholine receptors Presynaptic nicotinic acetylcholine receptors Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Highly calcium permeable nicotinic acetylcholine receptors Transmission across Chemical Synapses	Laminin interactions ECM proteoglycans Integrin cell surface interactions
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: CHRND CHRNE CHRNG ITGA7	4 interactors: CHRNA1 FHL2 FHL3 MYOC
Entrez ID		1134	3679
HPRD ID		00007	02761
Ensembl ID		ENSG00000138435	ENSG00000135424
Uniprot IDs		P02708 Q53SH4	J3KNV4 Q13683 Q4LE35
PDB IDs		1Y5P 1Y5T 1Y6C
Enriched GO Terms of Interacting Partners?		Muscle Contraction Muscle System Process Regulation Of Membrane Potential Synaptic Transmission Skeletal Muscle Tissue Development Cell-cell Signaling Skeletal Muscle Organ Development Cation Transmembrane Transport Skeletal Muscle Tissue Growth Cation Transport Ion Transmembrane Transport Muscle Organ Development Striated Muscle Tissue Development Muscle Tissue Development Transmembrane Transport Ion Transport Synaptic Transmission, Cholinergic Signal Transduction Muscle Structure Development Signaling Cell Communication Heterotypic Cell-cell Adhesion Skeletal Muscle Contraction Cellular Response To Stimulus Endodermal Cell Differentiation Musculoskeletal Movement Endoderm Formation Striated Muscle Contraction Response To Stimulus Endoderm Development Integrin-mediated Signaling Pathway Neuromuscular Process Formation Of Primary Germ Layer Regulation Of Cell Shape Cell-matrix Adhesion Tissue Development	Muscle Structure Development Skeletal Muscle Hypertrophy ERBB2-ERBB3 Signaling Pathway Osteoblast Differentiation Organ Development ERBB2 Signaling Pathway Atrial Cardiac Muscle Cell Development Skeletal Muscle Tissue Growth Muscle System Process Muscle Organ Development Ossification Non-canonical Wnt Signaling Pathway Via JNK Cascade System Development Striated Muscle Tissue Development Neuron Cellular Homeostasis Non-canonical Wnt Signaling Pathway Via MAPK Cascade Muscle Tissue Development Clustering Of Voltage-gated Sodium Channels Skeletal Muscle Adaptation Positive Regulation Of Mitochondrial Depolarization Multicellular Organismal Development Negative Regulation Of Stress Fiber Assembly Anatomical Structure Development Neuronal Ion Channel Clustering Negative Regulation Of Actin Filament Bundle Assembly Heart Trabecula Formation Developmental Process Regulation Of Mitochondrial Depolarization Ventricular Cardiac Muscle Cell Development Negative Regulation Of Rho Protein Signal Transduction Neuromuscular Synaptic Transmission Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Adherens Junction Organization Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Muscle Cell Cellular Homeostasis Heart Trabecula Morphogenesis Muscle Hypertrophy Ventricular Cardiac Muscle Cell Differentiation Skeletal Muscle Contraction Neuron Maturation Neuronal Action Potential Non-canonical Wnt Signaling Pathway Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Membrane Depolarization Negative Regulation Of Cell-matrix Adhesion Androgen Receptor Signaling Pathway Musculoskeletal Movement Positive Regulation Of Stress Fiber Assembly Myelination In Peripheral Nervous System Regulation Of Focal Adhesion Assembly
Tagcloud ?		ags aire autoimmune autoimmunity copies ds dysregulation euploid fundamental gad1 graves hypothyroidism intrathymic klk3 owing pge plp1 predisposition promiscuous restricted sag strikingly thymus thymuses thyroglobulin thyroiditis tolerance trisomy typically
Tagcloud (Difference) ?		ags aire autoimmune autoimmunity copies ds dysregulation euploid fundamental gad1 graves hypothyroidism intrathymic klk3 owing pge plp1 predisposition promiscuous restricted sag strikingly thymus thymuses thyroglobulin thyroiditis tolerance trisomy typically
Tagcloud (Intersection) ?