CHRNA1 and LILRB3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CHRNA1	LILRB3
Description		cholinergic receptor nicotinic alpha 1 subunit	leukocyte immunoglobulin like receptor B3
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Acetylcholine-gated Channel Complex Cell Surface Membrane Neuromuscular Junction Neuron Projection Synapse Postsynaptic Membrane Presynapse Postsynaptic Specialization Membrane	Plasma Membrane Membrane Secretory Granule Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Monoatomic Ion Channel Activity Extracellular Ligand-gated Monoatomic Ion Channel Activity Acetylcholine Receptor Activity Acetylcholine-gated Monoatomic Cation-selective Channel Activity Acetylcholine Binding Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential	Amyloid-beta Binding Transmembrane Signaling Receptor Activity Protein Binding Inhibitory MHC Class I Receptor Activity Signaling Receptor Activity
	Biological Process	Skeletal Muscle Contraction Monoatomic Ion Transport Monoatomic Cation Transport Synaptic Transmission, Cholinergic Neuromuscular Synaptic Transmission Neuromuscular Junction Development Neuronal Action Potential Monoatomic Ion Transmembrane Transport Response To Nicotine Regulation Of Membrane Potential Muscle Cell Cellular Homeostasis Skeletal Muscle Tissue Growth Musculoskeletal Movement Neuromuscular Process Membrane Depolarization Regulation Of Postsynaptic Membrane Potential Excitatory Postsynaptic Potential Neuron Cellular Homeostasis Acetylcholine Receptor Signaling Pathway Presynaptic Modulation Of Chemical Synaptic Transmission	Adaptive Immune Response Immune System Process Immune Response-regulating Signaling Pathway Defense Response Cell Surface Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Negative Regulation Of Osteoclast Differentiation
Pathways		Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Highly calcium permeable nicotinic acetylcholine receptors
Drugs		Lamotrigine Cisatracurium Agmatine
Diseases		Congenital myasthenic syndrome Multiple pterygium syndrome, including: Multiple pterygium syndrome, lethal type (LMPS); Multiple pterygium syndrome, Escobar variant (EVMPS)
GWAS		Atrial fibrillation ( 29892015)	Birth weight ( 31043758) Monocyte count ( 32888494) Takayasu arteritis ( 25604533)
Interacting Genes		5 interacting genes: CHRND CHRNE CHRNG ITGA7 LILRB3	3 interacting genes: CHRNA1 GRID1 RPL38
Entrez ID		1134	11025
HPRD ID		00007	11995
Ensembl ID		ENSG00000138435	ENSG00000204577
Uniprot IDs		P02708 Q53SH4	C9JWL8
PDB IDs		4ZJS 5HBT
Enriched GO Terms of Interacting Partners?		Acetylcholine-gated Monoatomic Cation-selective Channel Activity Acetylcholine Receptor Activity Acetylcholine-gated Channel Complex Synaptic Transmission, Cholinergic Extracellular Ligand-gated Monoatomic Ion Channel Activity Skeletal Muscle Contraction Acetylcholine Receptor Signaling Pathway Transmembrane Signaling Receptor Activity Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Postsynaptic Signal Transduction Membrane Depolarization Excitatory Postsynaptic Potential Striated Muscle Contraction Regulation Of Postsynaptic Membrane Potential Monoatomic Ion Channel Activity Muscle Contraction Postsynaptic Membrane Muscle System Process Chemical Synaptic Transmission Trans-synaptic Signaling Neuron Projection Synaptic Signaling Regulation Of Membrane Potential Neuromuscular Junction Cell-cell Signaling Signaling Cell Communication Monoatomic Ion Transmembrane Transport Signal Transduction Plasma Membrane Monoatomic Ion Transport Synapse Skeletal Muscle Tissue Growth Inhibitory MHC Class I Receptor Activity Regulation Of Biological Quality Signaling Receptor Activity Transmembrane Transport Acetylcholine Binding Musculoskeletal Movement Monoatomic Cation Transmembrane Transporter Activity System Process Integrin Complex Postsynaptic Specialization Membrane Ligand-gated Monoatomic Ion Channel Activity Negative Regulation Of Osteoclast Differentiation Membrane Heterotypic Cell-cell Adhesion Endodermal Cell Differentiation Channel Activity Negative Regulation Of Myeloid Leukocyte Differentiation	Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Synapse Regulation Of Postsynaptic Membrane Potential 90S Preribosome Assembly Eukaryotic 80S Initiation Complex Monoatomic Ion Channel Activity Postsynaptic Membrane G Protein-coupled Receptor Activity Involved In Regulation Of Postsynaptic Membrane Potential Negative Regulation Of Synaptic Plasticity Skeletal Muscle Tissue Growth Chemical Synaptic Transmission GABA Receptor Activity Trans-synaptic Protein Complex AMPA Glutamate Receptor Activity Axial Mesoderm Development Trans-synaptic Signaling Synaptic Signaling Acetylcholine Binding Synaptic Signaling Via Neuropeptide Regulation Of Membrane Potential Acetylcholine Receptor Activity Musculoskeletal Movement Acetylcholine-gated Monoatomic Cation-selective Channel Activity Modulation Of Chemical Synaptic Transmission Acetylcholine-gated Channel Complex Cell-cell Signaling Middle Ear Morphogenesis Synaptic Transmission, Cholinergic Signaling Muscle Cell Cellular Homeostasis Cell Communication AMPA Glutamate Receptor Complex Neuronal Action Potential Monoatomic Ion Transmembrane Transport Neuromuscular Synaptic Transmission Postsynaptic Specialization Membrane Ionotropic Glutamate Receptor Signaling Pathway Ligand-gated Monoatomic Ion Channel Activity Skeletal Muscle Contraction Extracellular Ligand-gated Monoatomic Ion Channel Activity Neuromuscular Junction Development Presynaptic Modulation Of Chemical Synaptic Transmission Response To Nicotine Acetylcholine Receptor Signaling Pathway Nervous System Process Synaptic Transmission, Glutamatergic Ligand-gated Ion Channel Signaling Pathway Monoatomic Ion Transport Postsynaptic Signal Transduction Glutamate Receptor Signaling Pathway
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