CHRNA1 and CHRND

Number of citations of the paper that reports this interaction (PubMedID 7695910)
0

Data Source:
HPRD (in vitro)

		CHRNA1	CHRND
Description		cholinergic receptor nicotinic alpha 1 subunit	cholinergic receptor nicotinic delta subunit
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Acetylcholine-gated Channel Complex Cell Surface Membrane Neuromuscular Junction Neuron Projection Synapse Postsynaptic Membrane Presynapse Postsynaptic Specialization Membrane	Plasma Membrane Acetylcholine-gated Channel Complex Membrane Neuromuscular Junction Neuron Projection Synapse Postsynaptic Membrane Postsynaptic Specialization Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Monoatomic Ion Channel Activity Extracellular Ligand-gated Monoatomic Ion Channel Activity Acetylcholine Receptor Activity Acetylcholine-gated Monoatomic Cation-selective Channel Activity Acetylcholine Binding Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential	Transmembrane Signaling Receptor Activity Monoatomic Ion Channel Activity Extracellular Ligand-gated Monoatomic Ion Channel Activity Ligand-gated Monoatomic Ion Channel Activity Acetylcholine Receptor Activity Acetylcholine-gated Monoatomic Cation-selective Channel Activity Acetylcholine Binding Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Skeletal Muscle Contraction Monoatomic Ion Transport Monoatomic Cation Transport Synaptic Transmission, Cholinergic Neuromuscular Synaptic Transmission Neuromuscular Junction Development Neuronal Action Potential Monoatomic Ion Transmembrane Transport Response To Nicotine Regulation Of Membrane Potential Muscle Cell Cellular Homeostasis Skeletal Muscle Tissue Growth Musculoskeletal Movement Neuromuscular Process Membrane Depolarization Regulation Of Postsynaptic Membrane Potential Excitatory Postsynaptic Potential Neuron Cellular Homeostasis Acetylcholine Receptor Signaling Pathway Presynaptic Modulation Of Chemical Synaptic Transmission	Skeletal Muscle Contraction Monoatomic Ion Transport Monoatomic Cation Transport Muscle Contraction Signal Transduction Chemical Synaptic Transmission Synaptic Transmission, Cholinergic Monoatomic Ion Transmembrane Transport Regulation Of Membrane Potential Skeletal Muscle Tissue Growth Musculoskeletal Movement Neuromuscular Process Membrane Depolarization Regulation Of Postsynaptic Membrane Potential Excitatory Postsynaptic Potential Acetylcholine Receptor Signaling Pathway
Pathways		Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Highly calcium permeable nicotinic acetylcholine receptors	Highly sodium permeable postsynaptic acetylcholine nicotinic receptors
Drugs		Lamotrigine Cisatracurium Agmatine
Diseases		Congenital myasthenic syndrome Multiple pterygium syndrome, including: Multiple pterygium syndrome, lethal type (LMPS); Multiple pterygium syndrome, Escobar variant (EVMPS)	Congenital myasthenic syndrome Multiple pterygium syndrome, including: Multiple pterygium syndrome, lethal type (LMPS); Multiple pterygium syndrome, Escobar variant (EVMPS)
GWAS		Atrial fibrillation ( 29892015)	Brain lesion load ( 19010793) Refractive error ( 32231278)
Interacting Genes		5 interacting genes: CHRND CHRNE CHRNG ITGA7 LILRB3	3 interacting genes: CHRNA1 GRB2 SNCA
Entrez ID		1134	1144
HPRD ID		00007	01516
Ensembl ID		ENSG00000138435	ENSG00000135902
Uniprot IDs		P02708 Q53SH4	B4E3W4 Q07001
PDB IDs		4ZJS 5HBT
Enriched GO Terms of Interacting Partners?		Acetylcholine-gated Monoatomic Cation-selective Channel Activity Acetylcholine Receptor Activity Acetylcholine-gated Channel Complex Synaptic Transmission, Cholinergic Extracellular Ligand-gated Monoatomic Ion Channel Activity Skeletal Muscle Contraction Acetylcholine Receptor Signaling Pathway Transmembrane Signaling Receptor Activity Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Postsynaptic Signal Transduction Membrane Depolarization Excitatory Postsynaptic Potential Striated Muscle Contraction Regulation Of Postsynaptic Membrane Potential Monoatomic Ion Channel Activity Muscle Contraction Postsynaptic Membrane Muscle System Process Chemical Synaptic Transmission Trans-synaptic Signaling Neuron Projection Synaptic Signaling Regulation Of Membrane Potential Neuromuscular Junction Cell-cell Signaling Signaling Cell Communication Monoatomic Ion Transmembrane Transport Signal Transduction Plasma Membrane Monoatomic Ion Transport Synapse Skeletal Muscle Tissue Growth Inhibitory MHC Class I Receptor Activity Regulation Of Biological Quality Signaling Receptor Activity Transmembrane Transport Acetylcholine Binding Musculoskeletal Movement Monoatomic Cation Transmembrane Transporter Activity System Process Integrin Complex Postsynaptic Specialization Membrane Ligand-gated Monoatomic Ion Channel Activity Negative Regulation Of Osteoclast Differentiation Membrane Heterotypic Cell-cell Adhesion Endodermal Cell Differentiation Channel Activity Negative Regulation Of Myeloid Leukocyte Differentiation	Excitatory Postsynaptic Potential Receptor Internalization Positive Regulation Of Reactive Oxygen Species Metabolic Process Guanyl-nucleotide Exchange Factor Adaptor Activity Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Alkylglycerone-phosphate Synthase Activity Regulation Of Postsynaptic Membrane Potential Negative Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Grb2-EGFR Complex Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Positive Regulation Of Axon Extension Involved In Axon Guidance Negative Regulation Of Chondrocyte Proliferation Regulation Of Lung Blood Pressure Aortic Valve Development Pulmonary Valve Development Tricuspid Valve Morphogenesis Venous Blood Vessel Development Negative Regulation Of Cell Proliferation Involved In Heart Morphogenesis Activin Receptor Activity, Type II Endochondral Bone Morphogenesis Semi-lunar Valve Development Skeletal Muscle Tissue Growth Cell Cortex Protein Domain Specific Binding Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Protein-containing Complex Assembly Receptor-mediated Endocytosis Neurotrophin TRKA Receptor Binding Negative Regulation Of Dopamine Metabolic Process Negative Regulation Of Serotonin Uptake Transporter Regulator Activity Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Catecholamine Metabolic Process Negative Regulation Of Chaperone-mediated Autophagy Regulation Of Serotonin Uptake Presynapse Lymphatic Endothelial Cell Differentiation BMP Receptor Activity Regulation Of Biological Quality Transforming Growth Factor Beta Receptor Activity Mitral Valve Morphogenesis Synapse Organization Regulation Of Chaperone-mediated Autophagy
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