CHRNA1 and CHRNE

Number of citations of the paper that reports this interaction (PMID 1712080)
12

Data Source:
HPRD (in vitro)

		CHRNA1	CHRNE
Gene Name		cholinergic receptor, nicotinic, alpha 1 (muscle)	cholinergic receptor, nicotinic, epsilon (muscle)
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Acetylcholine-gated Channel Complex Cell Surface Cell Junction Neuromuscular Junction Postsynaptic Membrane	Plasma Membrane Integral Component Of Plasma Membrane Acetylcholine-gated Channel Complex Cell Junction Postsynaptic Membrane
	Molecular Function	Acetylcholine-activated Cation-selective Channel Activity Ion Channel Activity Acetylcholine Receptor Activity Acetylcholine Binding	Acetylcholine-activated Cation-selective Channel Activity Cation Transmembrane Transporter Activity Acetylcholine Receptor Activity
	Biological Process	Skeletal Muscle Contraction Transport Signal Transduction Synaptic Transmission Neuromuscular Synaptic Transmission Neuromuscular Junction Development Neuronal Action Potential Ion Transmembrane Transport Regulation Of Membrane Potential Muscle Cell Cellular Homeostasis Skeletal Muscle Tissue Growth Musculoskeletal Movement Neuromuscular Process Neuron Cellular Homeostasis Cation Transmembrane Transport	Transport Muscle Contraction Signal Transduction Synaptic Transmission Synaptic Transmission, Cholinergic Regulation Of Membrane Potential Cation Transmembrane Transport
Pathways		Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Acetylcholine Binding And Downstream Events Activation of Nicotinic Acetylcholine Receptors Postsynaptic nicotinic acetylcholine receptors Presynaptic nicotinic acetylcholine receptors Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Highly calcium permeable nicotinic acetylcholine receptors Transmission across Chemical Synapses	Acetylcholine Binding And Downstream Events Postsynaptic nicotinic acetylcholine receptors Activation of Nicotinic Acetylcholine Receptors Presynaptic nicotinic acetylcholine receptors Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Highly sodium permeable acetylcholine nicotinic receptors Transmission across Chemical Synapses
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: CHRND CHRNE CHRNG ITGA7	1 interactors: CHRNA1
Entrez ID		1134	1145
HPRD ID		00007	00008
Ensembl ID		ENSG00000138435	ENSG00000108556
Uniprot IDs		P02708 Q53SH4	Q04844
PDB IDs		1Y5P 1Y5T 1Y6C	2DF9
Enriched GO Terms of Interacting Partners?		Muscle Contraction Muscle System Process Regulation Of Membrane Potential Synaptic Transmission Skeletal Muscle Tissue Development Cell-cell Signaling Skeletal Muscle Organ Development Cation Transmembrane Transport Skeletal Muscle Tissue Growth Cation Transport Ion Transmembrane Transport Muscle Organ Development Striated Muscle Tissue Development Muscle Tissue Development Transmembrane Transport Ion Transport Synaptic Transmission, Cholinergic Signal Transduction Muscle Structure Development Signaling Cell Communication Heterotypic Cell-cell Adhesion Skeletal Muscle Contraction Cellular Response To Stimulus Endodermal Cell Differentiation Musculoskeletal Movement Endoderm Formation Striated Muscle Contraction Response To Stimulus Endoderm Development Integrin-mediated Signaling Pathway Neuromuscular Process Formation Of Primary Germ Layer Regulation Of Cell Shape Cell-matrix Adhesion Tissue Development	Skeletal Muscle Tissue Growth Neuron Cellular Homeostasis Neuromuscular Synaptic Transmission Muscle Cell Cellular Homeostasis Skeletal Muscle Contraction Neuronal Action Potential Musculoskeletal Movement Neuromuscular Junction Development Transmission Of Nerve Impulse Striated Muscle Contraction Action Potential Neuromuscular Process Skeletal Muscle Tissue Development Skeletal Muscle Organ Development Synapse Organization Muscle Contraction Muscle System Process Regulation Of Membrane Potential Muscle Organ Development Developmental Growth Striated Muscle Tissue Development Muscle Tissue Development Growth Muscle Structure Development
Tagcloud ?		ags aire autoimmune autoimmunity copies ds dysregulation euploid fundamental gad1 graves hypothyroidism intrathymic klk3 owing pge plp1 predisposition promiscuous restricted sag strikingly thymus thymuses thyroglobulin thyroiditis tolerance trisomy typically	16x10 associations comprehensively dysregulated escc esccs esophageal fyn gc gcs germline gnai3 han itch map2k1 map2k4 mapk8 observe pak4 pik3r3 plcg2 prlr rank resampling rps6kb2 tln1 validate warranted wasl
Tagcloud (Difference) ?		ags aire autoimmune autoimmunity copies ds dysregulation euploid fundamental gad1 graves hypothyroidism intrathymic klk3 owing pge plp1 predisposition promiscuous restricted sag strikingly thymus thymuses thyroglobulin thyroiditis tolerance trisomy typically	16x10 associations comprehensively dysregulated escc esccs esophageal fyn gc gcs germline gnai3 han itch map2k1 map2k4 mapk8 observe pak4 pik3r3 plcg2 prlr rank resampling rps6kb2 tln1 validate warranted wasl
Tagcloud (Intersection) ?