CHRNA1 and CHRNE

Number of citations of the paper that reports this interaction (PubMedID 1712080)
0

Data Source:
HPRD (in vitro)

		CHRNA1	CHRNE
Description		cholinergic receptor nicotinic alpha 1 subunit	cholinergic receptor nicotinic epsilon subunit
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Acetylcholine-gated Channel Complex Cell Surface Membrane Neuromuscular Junction Neuron Projection Synapse Postsynaptic Membrane Presynapse Postsynaptic Specialization Membrane	Plasma Membrane Acetylcholine-gated Channel Complex Membrane Neuromuscular Junction Neuron Projection Synapse Postsynaptic Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Monoatomic Ion Channel Activity Extracellular Ligand-gated Monoatomic Ion Channel Activity Acetylcholine Receptor Activity Acetylcholine-gated Monoatomic Cation-selective Channel Activity Acetylcholine Binding Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential	Transmembrane Signaling Receptor Activity Monoatomic Ion Channel Activity Extracellular Ligand-gated Monoatomic Ion Channel Activity Monoatomic Cation Transmembrane Transporter Activity Acetylcholine Receptor Activity Acetylcholine-gated Monoatomic Cation-selective Channel Activity Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Skeletal Muscle Contraction Monoatomic Ion Transport Monoatomic Cation Transport Synaptic Transmission, Cholinergic Neuromuscular Synaptic Transmission Neuromuscular Junction Development Neuronal Action Potential Monoatomic Ion Transmembrane Transport Response To Nicotine Regulation Of Membrane Potential Muscle Cell Cellular Homeostasis Skeletal Muscle Tissue Growth Musculoskeletal Movement Neuromuscular Process Membrane Depolarization Regulation Of Postsynaptic Membrane Potential Excitatory Postsynaptic Potential Neuron Cellular Homeostasis Acetylcholine Receptor Signaling Pathway Presynaptic Modulation Of Chemical Synaptic Transmission	Skeletal Muscle Contraction Monoatomic Ion Transport Muscle Contraction Signal Transduction Chemical Synaptic Transmission Synaptic Transmission, Cholinergic Monoatomic Ion Transmembrane Transport Regulation Of Membrane Potential Membrane Depolarization Regulation Of Postsynaptic Membrane Potential Excitatory Postsynaptic Potential Acetylcholine Receptor Signaling Pathway Monoatomic Cation Transmembrane Transport
Pathways		Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Highly calcium permeable nicotinic acetylcholine receptors	Highly sodium permeable postsynaptic acetylcholine nicotinic receptors
Drugs		Lamotrigine Cisatracurium Agmatine
Diseases		Congenital myasthenic syndrome Multiple pterygium syndrome, including: Multiple pterygium syndrome, lethal type (LMPS); Multiple pterygium syndrome, Escobar variant (EVMPS)	Congenital myasthenic syndrome
GWAS		Atrial fibrillation ( 29892015)	Alzheimer's disease ( 34099642) Keratoconus ( 33649486) Platelet count ( 29403010)
Interacting Genes		5 interacting genes: CHRND CHRNE CHRNG ITGA7 LILRB3	1 interacting genes: CHRNA1
Entrez ID		1134	1145
HPRD ID		00007	00008
Ensembl ID		ENSG00000138435	ENSG00000108556
Uniprot IDs		P02708 Q53SH4	Q04844
PDB IDs		4ZJS 5HBT
Enriched GO Terms of Interacting Partners?		Acetylcholine-gated Monoatomic Cation-selective Channel Activity Acetylcholine Receptor Activity Acetylcholine-gated Channel Complex Synaptic Transmission, Cholinergic Extracellular Ligand-gated Monoatomic Ion Channel Activity Skeletal Muscle Contraction Acetylcholine Receptor Signaling Pathway Transmembrane Signaling Receptor Activity Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Postsynaptic Signal Transduction Membrane Depolarization Excitatory Postsynaptic Potential Striated Muscle Contraction Regulation Of Postsynaptic Membrane Potential Monoatomic Ion Channel Activity Muscle Contraction Postsynaptic Membrane Muscle System Process Chemical Synaptic Transmission Trans-synaptic Signaling Neuron Projection Synaptic Signaling Regulation Of Membrane Potential Neuromuscular Junction Cell-cell Signaling Signaling Cell Communication Monoatomic Ion Transmembrane Transport Signal Transduction Plasma Membrane Monoatomic Ion Transport Synapse Skeletal Muscle Tissue Growth Inhibitory MHC Class I Receptor Activity Regulation Of Biological Quality Signaling Receptor Activity Transmembrane Transport Acetylcholine Binding Musculoskeletal Movement Monoatomic Cation Transmembrane Transporter Activity System Process Integrin Complex Postsynaptic Specialization Membrane Ligand-gated Monoatomic Ion Channel Activity Negative Regulation Of Osteoclast Differentiation Membrane Heterotypic Cell-cell Adhesion Endodermal Cell Differentiation Channel Activity Negative Regulation Of Myeloid Leukocyte Differentiation	Acetylcholine Binding Acetylcholine Receptor Activity Skeletal Muscle Tissue Growth Musculoskeletal Movement Acetylcholine-gated Monoatomic Cation-selective Channel Activity Acetylcholine-gated Channel Complex Response To Nitrosative Stress MAP Kinase Tyrosine/serine/threonine Phosphatase Activity Protein Tyrosine/threonine Phosphatase Activity MAP Kinase Tyrosine Phosphatase Activity Protein Tyrosine/serine/threonine Phosphatase Activity Peptidyl-tyrosine Dephosphorylation Synaptic Transmission, Cholinergic Muscle Cell Cellular Homeostasis Neuromuscular Junction Development Extracellular Ligand-gated Monoatomic Ion Channel Activity Presynaptic Modulation Of Chemical Synaptic Transmission Skeletal Muscle Contraction Neuronal Action Potential Neuromuscular Synaptic Transmission Postsynaptic Specialization Membrane Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Response To Nicotine Acetylcholine Receptor Signaling Pathway Postsynaptic Signal Transduction Membrane Depolarization ERK1 And ERK2 Cascade Excitatory Postsynaptic Potential Neuron Cellular Homeostasis Regulation Of Heart Growth Negative Regulation Of ERK1 And ERK2 Cascade Neuromuscular Junction Striated Muscle Contraction Protein Serine/threonine Phosphatase Activity Protein Dephosphorylation Regulation Of Organ Growth Protein Tyrosine Phosphatase Activity Regulation Of Postsynaptic Membrane Potential Action Potential Neuromuscular Process
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