PLCD3 and SKIL

Number of citations of the paper that reports this interaction (PMID 15231748)
65

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PLCD3	SKIL
Gene Name		phospholipase C, delta 3	SKI-like proto-oncogene
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Cleavage Furrow	Acrosomal Vesicle Nucleus Nucleoplasm Cytoplasm PML Body Protein Complex
	Molecular Function	Phosphatidylinositol Phospholipase C Activity Signal Transducer Activity Metal Ion Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription DNA Binding Chromatin Binding Transcription Corepressor Activity Protein Binding Protein Domain Specific Binding Protein Complex Binding SMAD Binding
	Biological Process	Angiogenesis Lipid Catabolic Process Intracellular Signal Transduction Regulation Of Cell Proliferation Inositol Phosphate Metabolic Process Small Molecule Metabolic Process Labyrinthine Layer Blood Vessel Development	Negative Regulation Of Transcription From RNA Polymerase II Promoter Blastocyst Formation Lymphocyte Homeostasis Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Cell Cycle Arrest Transforming Growth Factor Beta Receptor Signaling Pathway Spermatogenesis Skeletal Muscle Tissue Development Gene Expression Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Response To Cytokine Regulation Of Apoptotic Process Negative Regulation Of Cell Differentiation Response To Antibiotic Positive Regulation Of Axonogenesis Protein Homotrimerization Protein Heterotrimerization Lens Fiber Cell Differentiation Response To Growth Factor Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Pathways		Synthesis of IP3 and IP4 in the cytosol Inositol phosphate metabolism	Loss of Function of TGFBR2 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer Downregulation of SMAD2/3:SMAD4 transcriptional activity TGFBR1 LBD Mutants in Cancer Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Loss of Function of TGFBR1 in Cancer Generic Transcription Pathway Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS		Systolic blood pressure ( 19430483)	Prostate cancer ( 21743467)
Protein-Protein Interactions		1 interactors: SKIL	90 interactors: AES ASCC3 C12orf10 CAMSAP1 CBX4 CDC16 CDC27 CHD3 CHPF COL4A2 CPNE1 CPNE2 CPNE4 CXXC5 DHX30 DRG1 EEF1G EIF4G2 ESR1 FAF1 FBLN1 FN1 FZR1 GLUL GOLGB1 HEY1 HEYL HIPK1 HIPK3 IL36RN KRT81 LRP1 MACF1 MORC4 MVP NCOR1 NCOR2 NID1 NID2 NXF3 OIP5 PAPPA PIAS1 PIAS3 PIAS4 PLCD3 PPL PSG3 PSMC2 PTPRF PYCR2 RNF4 RPS27 SASH1 SETDB1 SKI SMAD1 SMAD2 SMAD3 SMAD4 SMURF2 SNRNP70 SNX17 SPARCL1 SRP72 STK16 SVEP1 TDG TDP2 TFPI2 THAP5 THSD7A TPM2 TRAK1 TRIM62 TRIM69 TSKU TTF2 UBE2I UIMC1 USP25 VPS28 XRCC6 ZBTB3 ZBTB6 ZMYM2 ZMYM5 ZNF106 ZNF200 ZZEF1
Entrez ID		113026	6498
HPRD ID		07146	01319
Ensembl ID		ENSG00000161714	ENSG00000136603
Uniprot IDs		Q8N3E9	P12757
PDB IDs			3EQ5
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Protein Heterotrimerization Protein Homotrimerization Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Lens Fiber Cell Differentiation Protein Trimerization Blastocyst Formation Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Response To Antibiotic Positive Regulation Of Response To DNA Damage Stimulus Lymphocyte Homeostasis Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Axonogenesis Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Leukocyte Homeostasis Lens Development In Camera-type Eye Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Blastocyst Development Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Response To DNA Damage Stimulus Protein Heterooligomerization Skeletal Muscle Tissue Development Transforming Growth Factor Beta Receptor Signaling Pathway Cell Cycle Arrest Skeletal Muscle Organ Development Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Axonogenesis Positive Regulation Of Cell Morphogenesis Involved In Differentiation Transcription Initiation From RNA Polymerase II Promoter Response To Toxic Substance Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Neuron Projection Development DNA-templated Transcription, Initiation Homeostasis Of Number Of Cells Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Protein Homooligomerization Positive Regulation Of Cell Projection Organization Muscle Organ Development	Gene Expression RNA Biosynthetic Process Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process RNA Metabolic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of RNA Biosynthetic Process Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Gene Expression Response To Transforming Growth Factor Beta Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter SMAD Protein Complex Assembly Transforming Growth Factor Beta Receptor Signaling Pathway Protein Modification By Small Protein Conjugation Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Nitrogen Compound Metabolic Process Protein Sumoylation Nitrogen Compound Metabolic Process Cellular Metabolic Process Cellular Aromatic Compound Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Cellular Process Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Primary MiRNA Processing Cell Proliferation Positive Regulation Of Cellular Metabolic Process Protein K11-linked Ubiquitination DNA-templated Transcription, Initiation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Transcription From RNA Polymerase II Promoter Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Signaling Regulation Of Binding Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Signaling Gastrulation Proteasomal Protein Catabolic Process
Tagcloud ?		atp2b1 atxn2 bdkrb2 cacnb2 csk cyp171a cyp17a1 cyp1a2 eh gwas hfe jan meant mthfr nppa nppb nt5c2 overlapped pharmacogenomics plekha7 sh2b3 stk39 tbx3 tbx5 ulk3 ulk4 umod wnk4 znf652	applying associations assuming atm axin1 conserving deleterious endpoints ep300 ercc2 erythema exception gstp1 individually lig4 nos3 nqo1 radiosensitivity snp snps sod2 tgfb tgfb1 unravel weighted xdh xrcc1 xrcc3 xrcc6
Tagcloud (Difference) ?		atp2b1 atxn2 bdkrb2 cacnb2 csk cyp171a cyp17a1 cyp1a2 eh gwas hfe jan meant mthfr nppa nppb nt5c2 overlapped pharmacogenomics plekha7 sh2b3 stk39 tbx3 tbx5 ulk3 ulk4 umod wnk4 znf652	applying associations assuming atm axin1 conserving deleterious endpoints ep300 ercc2 erythema exception gstp1 individually lig4 nos3 nqo1 radiosensitivity snp snps sod2 tgfb tgfb1 unravel weighted xdh xrcc1 xrcc3 xrcc6
Tagcloud (Intersection) ?