XPOT and HDLBP

Number of citations of the paper that reports this interaction (PubMedID 10657246)
43

Data Source:
HPRD (in vitro)

		XPOT	HDLBP
Description		exportin for tRNA	high density lipoprotein binding protein
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Pore Nucleoplasm Cytoplasm Cytosol Nuclear Matrix	Nucleus Cytoplasm Plasma Membrane High-density Lipoprotein Particle
	Molecular Function	TRNA Binding RNA Binding Protein Binding Small GTPase Binding	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding Lipid Binding Cadherin Binding
	Biological Process	TRNA Export From Nucleus Intracellular Protein Transport Nucleocytoplasmic Transport TRNA Re-export From Nucleus	Lipid Metabolic Process Lipid Transport Steroid Metabolic Process Cholesterol Metabolic Process
Pathways		tRNA processing in the nucleus	HDL clearance
Drugs
Diseases
GWAS		Mean corpuscular hemoglobin ( 32888494)	Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Fibrinogen levels ( 26561523 28107422) HDL cholesterol levels ( 32203549) Intraocular pressure ( 29617998) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Prostate cancer ( 23535732) Serum alkaline phosphatase levels ( 33547301) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625)
Interacting Genes		13 interacting genes: CEBPA FILNC1 HDLBP HSPA13 KRT75 NUP153 NUP214 POU6F2 RAN RANBP2 RNF10 TRA2A XPO7	18 interacting genes: ADAR CDC42 CEBPA DHX9 ERBB2 ESR1 FILNC1 HMGB1 HMGB2 HSPB1 NEIL3 PLXNB2 RNF10 SMAD4 SOS1 SUMO2 TENT5A XPOT
Entrez ID		11260	3069
HPRD ID		04418	00813
Ensembl ID		ENSG00000184575	ENSG00000115677
Uniprot IDs		O43592	A0A024R4E5 B2R5V9 Q00341
PDB IDs			1VIG 1VIH 2CTE 2CTF 2CTJ 2CTK 2CTL 2CTM
Enriched GO Terms of Interacting Partners?		Nuclear Pore Nuclear Export Nuclear Export Signal Receptor Activity Nuclear Transport Nucleocytoplasmic Transport Regulation Of Nucleocytoplasmic Transport Import Into Nucleus Protein Export From Nucleus Protein Import Into Nucleus RNA Transport Negative Regulation Of RNA Export From Nucleus Protein Localization To Nucleus Nucleobase-containing Compound Transport Nuclear Envelope RNA Export From Nucleus Intracellular Protein Transport Nuclear Inclusion Body Regulation Of Intracellular Transport Nuclear Pore Nuclear Basket Regulation Of RNA Export From Nucleus Establishment Of Protein Localization To Organelle MRNA Transport Structural Constituent Of Nuclear Pore Nuclear Localization Sequence Binding Regulation Of Cellular Localization Nucleus RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Cytoplasmic Side Of Nuclear Pore Protein Transport Negative Regulation Of Intracellular Transport Protein Localization To Organelle Intracellular Transport Response To Vitamin B2 C/EBP Complex RNA Nuclear Export Complex SnRNA Import Into Nucleus Pre-miRNA Export From Nucleus Cytoplasmic Periphery Of The Nuclear Pore Complex Establishment Of Protein Localization Protein-containing Complex Binding CHOP-C/EBP Complex White Fat Cell Proliferation RNA Import Into Nucleus SUMO Ligase Complex Nuclear Pore Cytoplasmic Filaments Viral Penetration Into Host Nucleus Cholesterol Metabolic Process Sterol Metabolic Process Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex	Positive Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of Multicellular Organismal Development Positive Regulation Of Macromolecule Metabolic Process Regulation Of Cell Development Regulation Of Cell Population Proliferation RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Metabolic Process Regulation Of Multicellular Organismal Process Single-stranded DNA Binding Regulation Of Developmental Process Transcription Cis-regulatory Region Binding Regulation Of Cell Differentiation Double-stranded DNA Binding Positive Regulation Of Interferon-beta Production Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Multicellular Organismal Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Supercoiled DNA Binding Regulation Of Primary Metabolic Process Positive Regulation Of Cell Population Proliferation Regulation Of RNA Metabolic Process DNA Geometric Change Bubble DNA Binding Positive Regulation Of RNA Metabolic Process Regulation Of Interferon-beta Production Positive Regulation Of Viral Process Negative Regulation Of RNA Metabolic Process Damaged DNA Binding RISC Complex Assembly DNA Topological Change Positive Regulation Of Epithelial Cell Proliferation Regulation Of Nucleobase-containing Compound Metabolic Process Double-stranded RNA Binding Response To Stress RNA Binding Regulation Of Protein Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Hemopoiesis Cell Population Proliferation RAGE Receptor Binding Regulation Of Innate Immune Response Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process RNA Stabilization Protein-containing Complex
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