SEC23IP and SEC23A

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (two hybrid, affinity chromatography technology, biochemical)

		SEC23IP	SEC23A
Description		SEC23 interacting protein	SEC23 homolog A, COPII component
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Cytosol ER To Golgi Transport Vesicle Membrane Membrane COPII-coated ER To Golgi Transport Vesicle Cytoplasmic Vesicle	Golgi Membrane Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol ER To Golgi Transport Vesicle Membrane Membrane COPII Vesicle Coat COPII-coated ER To Golgi Transport Vesicle Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm Endoplasmic Reticulum Exit Site
	Molecular Function	RNA Binding Phospholipase Activity Protein Binding Metal Ion Binding	GTPase Activator Activity Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Golgi Organization Endomembrane System Organization	Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Protein Transport Vesicle-mediated Transport Protein Localization To Plasma Membrane COPII-coated Vesicle Cargo Loading COPII-coated Vesicle Budding
Pathways		COPII-mediated vesicle transport	Regulation of cholesterol biosynthesis by SREBP (SREBF) COPII-mediated vesicle transport MHC class II antigen presentation Cargo concentration in the ER SARS-CoV-2 activates/modulates innate and adaptive immune responses Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Drugs
Diseases			Cranio-lenticulo-sutural dysplasia (CLSD); Boyadjiev-Jabs syndrome
GWAS		Appendicular lean mass ( 33097823) Cerebrospinal fluid clusterin levels ( 26545630) HDL cholesterol levels ( 32203549) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Menarche (age at onset) ( 25231870)	Metabolite levels ( 23823483) Vitamin D levels ( 29343764)
Interacting Genes		10 interacting genes: BTG3 DSCR9 IFT25 PCNA POLD4 RNF10 SEC23A SSC5D WWOX YIF1A	33 interacting genes: BNIP3 CADPS CDK16 CDK18 CLEC17A DCTN1 DNM2 DTX2 ERGIC3 ERLIN1 FASLG FATE1 GJA8 GLRA2 HOMEZ MFF MIA2 MIA3 MINAR1 NDRG1 PIAS2 RNF19B SDCBP2 SEC16A SEC23IP SEC24B SEC24C SF1 SLC7A1 SUCLA2 TMEM45B TNFSF14 WBP11
Entrez ID		11196	10484
HPRD ID		07152	06714
Ensembl ID		ENSG00000107651	ENSG00000100934
Uniprot IDs		A0A994J542 Q9Y6Y8	Q15436
PDB IDs			2NUP 2NUT 2YRC 2YRD 3EFO 3EG9 3EGD 3EGX 5KYN 5KYU 5KYW 5KYX 5KYY 5VNE 5VNF 5VNG 5VNH 5VNI 5VNJ 5VNK 5VNL 5VNM 5VNN 5VNO 8HR0
Enriched GO Terms of Interacting Partners?		Mesenchymal Cell Differentiation Involved In Lung Development Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Fibroblast Growth Factor Receptor Signaling Pathway Involved In Negative Regulation Of Apoptotic Process In Bone Marrow Cell Fibroblast Growth Factor Receptor Signaling Pathway Involved In Mammary Gland Specification Fibroblast Growth Factor Receptor Signaling Pathway Involved In Positive Regulation Of Cell Proliferation In Bone Marrow Mammary Gland Bud Formation Fibroblast Growth Factor Receptor Signaling Pathway Involved In Hemopoiesis Squamous Basal Epithelial Stem Cell Differentiation Involved In Prostate Gland Acinus Development Branch Elongation Involved In Salivary Gland Morphogenesis Response To Transforming Growth Factor Beta Cellular Response To Transforming Growth Factor Beta Stimulus PCNA Complex PCNA-p21 Complex Replisome DNA Polymerase Processivity Factor Activity DNA Synthesis Involved In DNA Repair Purine-specific Mismatch Base Pair DNA N-glycosylase Activity COPII-coated ER To Golgi Transport Vesicle Ventricular Zone Neuroblast Division Prostate Epithelial Cord Elongation Prostate Gland Morphogenesis Mesenchymal Cell Proliferation Involved In Lung Development Fibroblast Growth Factor Receptor Activity Orbitofrontal Cortex Development Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis Lung Development Skeletal System Morphogenesis Positive Regulation Of Phospholipase Activity Forebrain Neuroblast Division DNA Biosynthetic Process Positive Regulation Of Deoxyribonuclease Activity Mitotic Telomere Maintenance Via Semi-conservative Replication Dinucleotide Insertion Or Deletion Binding Leading Strand Elongation Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane COPII-coated Vesicle Budding Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Delta DNA Polymerase Complex Detection Of Bacterial Lipoprotein	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Endoplasmic Reticulum Exit Site Golgi Vesicle Transport Protein Localization To Endoplasmic Reticulum Exit Site Vesicle Cargo Loading Protein Localization To Endoplasmic Reticulum ER To Golgi Transport Vesicle Membrane COPII-coated Vesicle Cargo Loading Vesicle-mediated Transport Membrane Establishment Of Localization In Cell Endoplasmic Reticulum Membrane Endoplasmic Reticulum Cytoplasmic Vesicle Intracellular Transport Regulation Of Plasma Membrane Organization COPII Vesicle Coat Lipoprotein Transport Establishment Of Protein Localization Positive Regulation Of Mitochondrial Fission Mitochondrial Calcium Ion Homeostasis Cell Morphogenesis Involved In Neuron Differentiation Protein Transport
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?