HFM1 and RPS27L

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		HFM1	RPS27L
Description		helicase for meiosis 1	ribosomal protein S27 like
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus	Nucleus Ribosome Cytosolic Small Ribosomal Subunit Ribonucleoprotein Complex
	Molecular Function	Nucleotide Binding Nucleic Acid Binding DNA Helicase Activity Helicase Activity ATP Binding Zinc Ion Binding Hydrolase Activity Isomerase Activity ATP Hydrolysis Activity Metal Ion Binding	RNA Binding Structural Constituent Of Ribosome Protein Binding Zinc Ion Binding Translation Activator Activity Metal Ion Binding
	Biological Process	Resolution Of Meiotic Recombination Intermediates Reciprocal Meiotic Recombination Meiotic Cell Cycle	Ribosomal Small Subunit Assembly Translation DNA Damage Response, Signal Transduction By P53 Class Mediator Mitotic G1 DNA Damage Checkpoint Signaling Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Translation
Pathways			L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency SARS-CoV-1 modulates host translation machinery SARS-CoV-2 modulates host translation machinery Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs
Diseases
GWAS		Metabolite levels ( 23823483) Response to fenofibrate (HDL cholesterol levels) ( 27002377)	Refractive error ( 32231278) Serum metabolite levels ( 23093944)
Interacting Genes		2 interacting genes: FAM107A RPS27L	3 interacting genes: CLIP4 HFM1 ZRSR2
Entrez ID		164045	51065
HPRD ID		18568	18003
Ensembl ID		ENSG00000162669	ENSG00000185088
Uniprot IDs		A2PYH4 B4DYS5	Q71UM5
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle G1/S Phase Transition Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Negative Regulation Of Long-term Synaptic Potentiation Translation Activator Activity Ribosomal Small Subunit Assembly Regulation Of Cell Cycle Process Mitotic G1 DNA Damage Checkpoint Signaling Mitotic G1/S Transition Checkpoint Signaling Positive Regulation Of Protein Metabolic Process Negative Regulation Of Focal Adhesion Assembly Actin Filament Polymerization Regulation Of Cell Cycle Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Cell-matrix Adhesion Cytosolic Small Ribosomal Subunit Regulation Of Long-term Synaptic Potentiation Protein-containing Complex Assembly DNA Damage Response, Signal Transduction By P53 Class Mediator Actin Polymerization Or Depolymerization Regulation Of Focal Adhesion Assembly Actin Filament Bundle Organization Cellular Response To Glucocorticoid Stimulus Cellular Response To Corticosteroid Stimulus Protein-containing Complex Organization Actin Filament Bundle Assembly Negative Regulation Of Cell-substrate Adhesion Regulation Of Protein Metabolic Process Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Mitotic DNA Damage Checkpoint Signaling Regulation Of Cell-substrate Junction Organization Protein Polymerization Mitotic DNA Integrity Checkpoint Signaling Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Cellular Response To Steroid Hormone Stimulus Stress Fiber Ruffle Membrane DNA Damage Checkpoint Signaling Signal Transduction By P53 Class Mediator Positive Regulation Of Protein Ubiquitination Positive Regulation Of Post-translational Protein Modification	Pre-mRNA 3'-splice Site Binding U2AF Complex U12-type Spliceosomal Complex Nucleic Acid Binding Microtubule Plus-end Binding Microtubule Plus-end Reciprocal Meiotic Recombination Resolution Of Meiotic Recombination Intermediates DNA Helicase Activity Homologous Recombination Spliceosomal Complex Assembly
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?