HHLA2 and UNC93B1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		HHLA2	UNC93B1
Description		HHLA2 member of B7 family	unc-93B1 regulator of TLR signaling
Image		No pdb structure
GO Annotations	Cellular Component	External Side Of Plasma Membrane Membrane	Golgi Membrane Lysosome Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Cytoplasmic Vesicle Early Phagosome Phagocytic Vesicle
	Molecular Function	Signaling Receptor Binding Protein Binding	Protein Binding Toll-like Receptor Binding
	Biological Process	Regulation Of Cytokine Production Positive Regulation Of Cytokine Production T Cell Costimulation Positive Regulation Of Activated T Cell Proliferation T Cell Receptor Signaling Pathway Regulation Of T Cell Activation Regulation Of Leukocyte Cell-cell Adhesion	Cell Morphogenesis Toll-like Receptor Signaling Pathway Adaptive Immune Response Immune System Process T Cell Antigen Processing And Presentation Intracellular Protein Transport Antigen Processing And Presentation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 7 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Innate Immune Response Defense Response To Virus
Pathways			Trafficking and processing of endosomal TLR UNC93B1 deficiency - HSE
Drugs
Diseases
GWAS		Regular attendance at a religious group ( 29970889)	Schizophrenia x sex interaction ( 34099189) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		14 interacting genes: AQP9 BRICD5 BTNL8 C3orf52 ERMP1 FAM3C NIPAL4 NRM PGA4 RPRM SMCO4 TMEM140 TNMD UNC93B1	31 interacting genes: AQP6 BEST2 CCDC107 CD79A CFTR CLDN7 CLPTM1 CREB3L1 CYB5R3 EBP ERGIC3 FATE1 FFAR3 FKBP7 GPR101 GPR37L1 GPRC5D HHLA2 KLRC1 LDLRAD1 LEUTX LIME1 MBOAT7 MFF REEP1 SLC16A2 SLC35H1 SSMEM1 SYNDIG1 TM4SF18 TMEM237
Entrez ID		11148	81622
HPRD ID		05082	12191
Ensembl ID		ENSG00000114455	ENSG00000110057
Uniprot IDs		C9J7D0 Q9UM44	Q9H1C4
PDB IDs			7C76 7CYN
Enriched GO Terms of Interacting Partners?			Membrane B Cell Receptor Complex Cholesterol Biosynthetic Process Sterol Biosynthetic Process Protein Binding Endoplasmic Reticulum Membrane Steroid Biosynthetic Process Receptor Complex
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