KATNB1 and DYNC1H1

Number of citations of the paper that reports this interaction (PMID 16203747)
30

Data Source:
BioGRID (pull down, affinity chromatography technology)

		KATNB1	DYNC1H1
Gene Name		katanin p80 (WD repeat containing) subunit B 1	dynein, cytoplasmic 1, heavy chain 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Spindle Pole Nucleus Cytoplasm Centrosome Microtubule Plasma Membrane Katanin Complex Microtubule Cytoskeleton Membrane Axon Growth Cone Midbody Neuronal Cell Body	Centrosome Cytosol Cytoplasmic Dynein Complex Microtubule Membrane Filopodium Extracellular Vesicular Exosome
	Molecular Function	Microtubule Binding Microtubule-severing ATPase Activity Dynein Binding Protein Heterodimerization Activity	Microtubule Motor Activity Protein Binding ATP Binding ATPase Activity Poly(A) RNA Binding Dynein Light Intermediate Chain Binding
	Biological Process	Protein Targeting Negative Regulation Of Microtubule Depolymerization Mitotic Chromosome Movement Towards Spindle Pole Metabolic Process Positive Regulation Of Cell Death Positive Regulation Of Neuron Projection Development Positive Regulation Of Microtubule Depolymerization Microtubule Severing Cell Division	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Transport Organelle Organization Microtubule-based Movement Mitotic Spindle Organization Metabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Cytoplasmic MRNA Processing Body Assembly Stress Granule Assembly
Pathways			Organelle biogenesis and maintenance Assembly of the primary cilium G2/M Transition Anchoring of the basal body to the plasma membrane Regulation of PLK1 Activity at G2/M Transition Cell Cycle, Mitotic Loss of proteins required for interphase microtubule organizationÂ from the centrosome Loss of Nlp from mitotic centrosomes MHC class II antigen presentation Centrosome maturation Mitotic G2-G2/M phases Recruitment of mitotic centrosome proteins and complexes Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: DYNC1H1 KATNA1 PAFAH1B1 TGFBR1 XRN1	14 interactors: BRCA1 DISC1 DYNLL1 EGFR FAM46A KATNA1 KATNB1 NDEL1 PRKCD SMAD2 SNCA TNIK YWHAG YWHAQ
Entrez ID		10300	1778
HPRD ID		04081	02524
Ensembl ID		ENSG00000140854	ENSG00000197102
Uniprot IDs		Q9BVA0	Q14204
PDB IDs			2BOR 2BOT
Enriched GO Terms of Interacting Partners?		Cell Cycle Process Cell Cycle Microtubule Cytoskeleton Organization Movement Of Cell Or Subcellular Component Regulation Of Cell Projection Organization Mitotic Cell Cycle Process Negative Regulation Of Neuron Projection Development Positive Regulation Of Cell Growth G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Differentiation Mitotic Cell Cycle Microtubule-based Process Negative Regulation Of Cell Projection Organization Cell Migration Regulation Of Cell Development Neuron Migration Cell Motility Ameboidal-type Cell Migration Establishment Of Centrosome Localization Negative Regulation Of Neuron Differentiation Positive Regulation Of Growth Platelet Activating Factor Metabolic Process Cytoskeleton Organization Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Positive Regulation Of Cell Projection Organization Nuclear MRNA Surveillance Locomotion Negative Regulation Of Neurogenesis Corpus Callosum Morphogenesis Microtubule-based Movement Mitotic Nuclear Division Parathyroid Gland Development Osteoclast Development RNA Surveillance Negative Regulation Of Cell Development Histone MRNA Catabolic Process Regulation Of Cell Growth Cytoplasmic MRNA Processing Body Assembly Retrograde Axon Cargo Transport Microtubule Severing RRNA Catabolic Process Endothelial Cell Activation Regulation Of Neuron Projection Development Generation Of Neurons Regulation Of Cell Differentiation Nuclear Migration Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of SMAD Protein Import Into Nucleus Neurogenesis	Regulation Of Cellular Component Organization Regulation Of Signal Transduction Regulation Of Signaling Intrinsic Apoptotic Signaling Pathway Developmental Process Positive Regulation Of Signal Transduction Intracellular Signal Transduction Regulation Of Cell Projection Organization Positive Regulation Of Intracellular Transport Regulation Of Cell Development Cell Cycle Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Organelle Organization Regulation Of Neuron Differentiation Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Cell Death Positive Regulation Of Cell Death Cell Cycle Process Nervous System Development Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Apoptotic Signaling Pathway Mitotic Cell Cycle Process Cellular Localization Regulation Of Neurogenesis Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Neuron Projection Development Negative Regulation Of Cytoskeleton Organization Positive Regulation Of Transport Mitotic Cell Cycle Positive Regulation Of Organelle Organization Microtubule-based Process Protein Localization Regulation Of Intracellular Transport Multicellular Organismal Development Positive Regulation Of Apoptotic Signaling Pathway Membrane Organization Positive Regulation Of Mitochondrion Organization Anatomical Structure Development Positive Regulation Of Protein Modification Process Regulation Of Apoptotic Process Positive Regulation Of Superoxide Anion Generation Positive Regulation Of Response To DNA Damage Stimulus Apoptotic Process Generation Of Neurons Regulation Of Cell Differentiation Microtubule Severing Programmed Cell Death Organelle Organization System Development Positive Regulation Of Apoptotic Process
Tagcloud ?			200x customized dcx depths exome flna funded heterotopia kif5c kinesin malformations megalencephaly mosaicism neurodevelopmental neuropsychiatric nodular pachygyria panels periventricular persons polymicrogyria read sanger somatic subcloned subcloning subcortical tubb2b unequal
Tagcloud (Difference) ?			200x customized dcx depths exome flna funded heterotopia kif5c kinesin malformations megalencephaly mosaicism neurodevelopmental neuropsychiatric nodular pachygyria panels periventricular persons polymicrogyria read sanger somatic subcloned subcloning subcortical tubb2b unequal
Tagcloud (Intersection) ?